Author(s): Rochmah Kurnijasanti, Amaq Fadholly

Email(s): rochmah-k@fkh.unair.ac.id

DOI: 10.52711/0974-360X.2021.00589   

Address: Rochmah Kurnijasanti1*, Amaq Fadholly2
1Department of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
2Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021


ABSTRACT:
Capsicum annum L. is a potential natural plant that have a lot of various pharmacological effects, including as anticancer agent. This study Aim to analyze Capsicum annum extract (CAE) on T47D cells. CAE (10, 20, 40, 60, 80µg/mL) treated on T47D cells to determined IC50 value by MTT assay. Apoptosis induction is also investigated through caspase-3 expressions (IC50, 2IC50). The present study showed that CAE suppress T47D cells proliferation with IC50 value of 75.81µg/mL. The caspase-3 expression on 2IC50 is higher (67.16%) than IC50 (52.16%). This result indicate that CAE has ability as anticancer agent by inhibiting cell growth and induce apoptosis through caspase-3 expression on T47D cells. Further study of CAE holds potential for novel therapies of cancer prevention and treatment.


Cite this article:
Rochmah Kurnijasanti, Amaq Fadholly. Cytotoxic Effect of Capsicum annum L. extract on T47D Cells: In vitro Study. Research Journal of Pharmacy and Technology. 2021; 14(6):3389-2. doi: 10.52711/0974-360X.2021.00589

Cite(Electronic):
Rochmah Kurnijasanti, Amaq Fadholly. Cytotoxic Effect of Capsicum annum L. extract on T47D Cells: In vitro Study. Research Journal of Pharmacy and Technology. 2021; 14(6):3389-2. doi: 10.52711/0974-360X.2021.00589   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-6-79


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