Author(s): Krishna Patel, Dipti Patel

Email(s): dipti2603@yahoo.com

DOI: 10.52711/0974-360X.2021.00585   

Address: Krishna Patel, Dipti Patel*
Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021


ABSTRACT:
A simple, specific and accurate reversed-phase high performance liquid chromatographic method was developed for the simultaneous determination of Capecitabine and Oxaliplatin, using a Hypersil BDS C18, 150x4.6 mm, 5µ column and a mobile phase composed of 10mM dipotassium hydrogen phosphate+0.1% TEA pH 5.0: Acetonitrile (50:50%v/v). The flow rate was 1.0 ml/min, and the detection wavelength was 245 nm. The injection volume was 20 µL. The retention times of Capecitabine and Oxaliplatin found 4.29 min and 5.52 min, respectively. Linearity was established for Capecitabine and Oxaliplatin in the range of 60-210µg/ml and 20-70 µg/ml, respectively. The percentage recoveries of Capecitabine and Oxaliplatin found to be in the range of 99.1-101.5% and 97.9-99.7 %, respectively. The proposed method validated for precision, accuracy, linearity range, and robustness. This method can successfully be employed for simultaneous quantitative analysis of Capecitabine and Oxaliplatin in the capsule.


Cite this article:
Krishna Patel, Dipti Patel. Simultaneous method development and Validation by HPLC for Capecitabine and Oxaliplatin in mucoadhesive microspheres containing capsules. Research Journal of Pharmacy and Technology. 2021; 14(6):3365-0. doi: 10.52711/0974-360X.2021.00585

Cite(Electronic):
Krishna Patel, Dipti Patel. Simultaneous method development and Validation by HPLC for Capecitabine and Oxaliplatin in mucoadhesive microspheres containing capsules. Research Journal of Pharmacy and Technology. 2021; 14(6):3365-0. doi: 10.52711/0974-360X.2021.00585   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-6-75


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DOI: 10.5958/0974-360X 

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