Author(s): Desy Ayu Irma Permatasari, Ritmaleni, Titik Nuryastuti

Email(s): ritmaleni@ugm.ac.id

DOI: 10.52711/0974-360X.2021.00566   

Address: Desy Ayu Irma Permatasari1, Ritmaleni2, Titik Nuryastuti3
1Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
3Department of Microbiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021


ABSTRACT:
Tuberculosis (TB) is an infectious disease caused by M. tuberculosis. A new series of four benzylformamide with chloro substitution were synthesized by multicomponent reaction method and screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv strain. This study was based on amidoalkylation reaction of aromatic-aldehyde, formamide and formic acid at 150oC to give a good yield of benzylformamide. Target compound were isolated, purificated, identified and characterized by GC-MS, FTIR, 1H-NMR, and 13C-NMR then the antituberculosis activity was examined by Microplate Alamar Blue Assay (MABA) and Middlebrook 7H9-7H11 medium in concentration series of 1000 – 1,954 µg/mL, and isoniazid as a positive control. Among the three derivative, N-(2,4-dichlorobenzyl) formamide has the most potential antituberculosis activity up to 500.0 L/mL.


Cite this article:
Desy Ayu Irma Permatasari, Ritmaleni, Titik Nuryastuti. N-(Chlorobenzyl) Formamide as an Antituberculosis Agent from Multicomponent Reaction Synthesis. Research Journal of Pharmacy and Technology. 2021; 14(6):3253-1. doi: 10.52711/0974-360X.2021.00566

Cite(Electronic):
Desy Ayu Irma Permatasari, Ritmaleni, Titik Nuryastuti. N-(Chlorobenzyl) Formamide as an Antituberculosis Agent from Multicomponent Reaction Synthesis. Research Journal of Pharmacy and Technology. 2021; 14(6):3253-1. doi: 10.52711/0974-360X.2021.00566   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-6-56


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