Author(s): Konda Mayuri, Kukkdapu Pavan Kumar, Neela Swapna, Chinnala Krishna Mohan

Email(s): kondamayuri@gmail.com

DOI: 10.52711/0974-360X.2021.00558   

Address: Konda Mayuri*, Kukkdapu Pavan Kumar, Neela Swapna, Chinnala Krishna Mohan
Department of Pharmaceutics, School of Pharmacy, Nalla Narasimha Reddy Educational Society’s Group of Institutions, Hyderabad, India - 500088.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021


ABSTRACT:
In human anatomy mouth is the earliest segment of alimentary canal which receives food and fabricates saliva, and is one of the foundation for bacterial development due to accretion of sugars form food chunks. There have been more than 300 kinds of bacteria set up in the mouth. The purpose of the present study is to investigate the number of microbes’ grown-up at different timings of the day by collecting the samples from individual volunteer oral cavities and counting the colonies; the utmost count was noted as in the range of 190-200 in the evening samples. The same samples were used to calculate minimum inhibitory concentration of Triclosan, the antibiotic formulated for oral hygiene. Triclosan dilutions were prepared and analyzed for the inhibition zones, it resulted that 300mg of the drug have shown satisfactory results. Triclosan was formulated into a dispersible tablet to enable dispersion of tablet into water for rinsing the oral cavity to remove the contaminants. The Dispersion time of the tablet was within the range of 43.66-111.33 second and it was observed that formulation was acceptable with reasonable limits of standard required for dispersible tablets. Addition of superdisintegrant enhanced the dispersion time which facilitates easy mixing of tablet in water. It concludes that superdisintegrant addition technique is a useful method for preparing dispersible tablets by wet granulation method, and Triclosan dispersible tablet further reduces the microbial attack on tooth by rinsing each time after meals, upon doing so on long term basis the dental decays will probably be eradicated.


Cite this article:
Konda Mayuri, Kukkdapu Pavan Kumar, Neela Swapna, Chinnala Krishna Mohan. Formulation and Evaluation of Triclosan Dispersible Tablets for Oral Hygiene. Research Journal of Pharmacy and Technology. 2021; 14(6):3202-8. doi: 10.52711/0974-360X.2021.00558

Cite(Electronic):
Konda Mayuri, Kukkdapu Pavan Kumar, Neela Swapna, Chinnala Krishna Mohan. Formulation and Evaluation of Triclosan Dispersible Tablets for Oral Hygiene. Research Journal of Pharmacy and Technology. 2021; 14(6):3202-8. doi: 10.52711/0974-360X.2021.00558   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-6-48


REFERENCES:
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2.    Kazor, C. E. et al. Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. J. Clin. Microbiol. 2003; 41:558-563.
3.    Kroes, I., P. W. Lepp, and D. A. Relman. Bacterial diversity within the human sub gingival crevice. Proc. Natl. Acad. Sci. USA. 1999; 96:14547-14552.
4.    Konda Mayuri*, et al , Immediate and Extended Release Capsule Formulation of Ajwain (Trachyspermum ammi) Fruit Extract, Int. J. Pharm. Sci. Rev. Res. 2017; 46(1) : 156-162.
5.    Shahi S.R., et al. Formulation and in vitro Evaluation of Oro-dispersible tablets of Etoricoxib with emphasis on comparative functionality evaluation of three classes of superdisintegrants. Rasayan J. Chem. 2008; 1 (2) : 292-300.
6.    Singh J., Singh R. Optimization and Formulation of Orodispersible tablets of Meloxicam, Tropical Journal of Pharmaceutical Research. 8,2;153-159, April 2009.
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