Author(s):
Shruti Ramesh Shettigar, Vanita G. Kanase
Email(s):
vanita.kanase@gmail.com
DOI:
10.52711/0974-360X.2021.00553 
Address:
Ms. Shruti Ramesh Shettigar1, Dr. (Mrs.) Vanita G. Kanase2*
1Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra 400705.
2HOD Pharmacology, Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra 400705.
*Corresponding Author
Published In:
Volume - 14,
Issue - 6,
Year - 2021
ABSTRACT:
Evaluation of anti-hyperuricemic activity of alcoholic extract of Capparis moonii Wight fruits in Wistar rats, by utilizing Indian caper typically occurring in the Konkan area which grows full-fledged in the hot and dry atmosphere that can be generally found throughout asia. The dried fruits of Capparis moonii W. were extracted using absolute ethanol to get an alcoholic extract. Acute oral toxicity studies were performed to decide the doses. The anti-hyperuricemic activity was estimated by the phenol red excretion in rats and the potassium oxonate induced hyperuricemia models respectively. The alcoholic extract showed dose-dependent mode of action where the higher concentration of 200 mg/kg showed higher amount of retention of phenol red in the blood suggesting that it has better ability to secrete urate out of the body of rats as compared to 100mg/kg. Also in potassium oxonate induced hyperuricemia, similar results were obtained with significant reduction in serum uric acid levels and serum creatinine levels as compared to 100mg/kg. The conclusion of this study was that; it proved that Capparis moonii W. alcoholic extract of the fruits can be beneficial as anti-hyperuricemic treatment agent. It would be encouraging to undertake further studies in future to decode the exact mechanism.
Cite this article:
Shruti Ramesh Shettigar, Vanita G. Kanase. Evaluation of Anti-hyperuricemic Activity of the Alcoholic Extract of Dried Capparis moonii Wight Fruits in Wistar Rats. Research Journal of Pharmacy and Technology. 2021; 14(6):3173-8. doi: 10.52711/0974-360X.2021.00553
Cite(Electronic):
Shruti Ramesh Shettigar, Vanita G. Kanase. Evaluation of Anti-hyperuricemic Activity of the Alcoholic Extract of Dried Capparis moonii Wight Fruits in Wistar Rats. Research Journal of Pharmacy and Technology. 2021; 14(6):3173-8. doi: 10.52711/0974-360X.2021.00553 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-6-43
REFERENCES:
1. Hickling D et al. Anatomy and physiology of the urinary tract: Relation to host defense and microbial infection. Microbiology Spectrum. 2015; 3(4):1-29.
2. Graaff, Van De. Human Anatomy, McGraw-Hill New York. 2002; 6th ed. pp. 676-688.
3. Benveniste H et al. The glymphatic pathway: Waste removal from the CNS via cerebrospinal fluid transport. Neuroscientistist. 2017; 23(5): 454-465.
4. Ibbara AM and Vaitla P. Histology, Nephron-NCBI Bookshelf, National Institutes of Health, Stat Pearls Publishing Treasure Island (FL). 2020.
5. Glassock R and Rule A. Aging and the kidneys: Anatomy, physiology and consequences for defining chronic kidney disease. Nephrology Clinical Practice. 2016; 134(1): 25-29.
6. Gliozzi M et al. The treatment of hyperuricemia. International Journal of Cardiology. 2016; 213: 23-27.
7. Becker M and Jolly M. Hyperuricemia and associated diseases. Rheumatic Disease Clinic of North America 2006. 32(2): 275-293.
8. Luk AJ et al. Epidemiology of hyperuricemia and gout. American Journal of Managed Care. 2005; 11(15): 435-442.
9. Wortmann R. Recent advances in the management of gout and hyperuricemia. Current Opinion in Rheumatology. 2005; 17: 1040-8711.
10. Yadav P et al. Estimation of antioxidant activity and total phenol, flavonoid content among natural populations of Caper (Capparis moonii, Wight) from Western Ghats Region. Indian Journal of Pharmaceutical Education And Research. 2016; 50(3): 495-501.
11. Mishra SN et al. Medicinal and food value of Capparis-a harsh terrain plant. Indian Journal of Traditional Knowledge. 2007; 6(1): 230-238.
12. Nagar L et al. Comprehensive ethnopharmacological review of rudanti (Capparis moonii Wight). International Journal of Pharmaceutical Sciences and Research. 2019; 11(2): 556-562.
13. Patil DA and Tayade SK. Plant names in sanskrit: A comparative philological investigation. South African Journal of Botany. 2017; 5(6): 446-452.
14. Lansky EP et al.Caper: The Genus Capparis (Traditional Herbal Medicines for Modern Times). 1st Edition. Boca Raton: CRC press. 2013; 54.
15. Sunarni T. et al. Antihyperuricemic activity of four plants annonaceae using hyperuricemic rats model and enzyme assay. Asian Journal of Pharmaceutical and Clinical Research. 2015; 8(6): 250-253.
16. Hameed B et al. Anti-hyperuricemic, uricosuric and xanthine-oxidase inhibitory activities of watermelon powder in a rat gout model. Journal of Biosciences. 2018; 18(8): 468-474.
17. Murugaiyah V and Chan K. Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. Journal of Ethnopharmacology. 2009; 124(2): 233-239.
18. Vanita G.Kanase et al. Evaluation of in-vitro immunomodulatory activity of aqueous and ethanolic extract of Capparis moonii. International Journal of Pharma and Bio Sciences. 2013; 4(2); 344-352.
19. Sathisha K et al. Antihyperuricemic effects of thiadiazolopyrimidin-5-one analogues in oxonate treated rats. European Journal of Pharmacology. 2016; 776: 99-105.
20. Chen Y et al. Beneficial effect of rutin on oxonate-induced hyperuricemia and renal dysfunction in mice. Pharmacology 92. 2013; 92(1-2): 75-83.
21. Zhu J et al. Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. Journal of Ethnopharmacology. 2004; 93(1): 133-140.
22. Stalikas C. Extraction, separation, and detection methods for phenolic acids and flavonoids. Journal of Separation Science. 2007; 30(18): 3268-3295.
23. Driscoll J et al. Phenolsulfonphthalein (Phenol Red) metabolism in primary monolayer cultures of adult rat. In vitro 1982; 18(10): 835-842.
24. Shah P and Shah G. Uricosuric activity of Tinospora cordifolia. Bangladesh Journal of Pharmacology. 2015; 10(4): 884-890.
25. Tang D et al. Potassium oxonate induces acute hyperuricemia in the tree shrew (Tupaia belangeri chinensis). Experimental Animals. 2017; 66(3): 209-216.