Author(s): Endang Sri Purwanti Ningsih, Noorlaila, Muhammad Ikhwan Rizki, Windy Yuliana Budianto


DOI: 10.52711/0974-360X.2021.00548   

Address: Endang Sri Purwanti Ningsih1, Noorlaila1, Muhammad Ikhwan Rizki2, Windy Yuliana Budianto3
1Department of Nursing, Health Polytechnic of Health Ministry Banjarmasin, Indonesia.
2Department of Pharmacy, Faculty of Science, Universitas Lambung Mangkurat, Banjarbaru.
3Department of Pediatric Nursing, Faculty of Medicine, Universitas Lambung Mangkurat, Jl. Ahmad Yani Km.36, Banjarbaru 70712, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021

Background: The process of wound healing is influenced by various factors such as age, hormones, and wound care. Wound care is done to accelerate wound healing which can be done by various methods, one of them is traditional care. Traditional wound care can use medicinal plants. Rhodomyrtus tomentosa is a medicinal plant that has an antioxidant, anti-inflammatory, antitumor and antibacterial content. Thus this study aims to evaluate the effectiveness of the antiseptic solution of the Rodhomyrtus tomentosa leaf extract on wound healing in male Wistar rats. Method: this research is pure experimental research with post test only control group design. Thirty male white rats were divided into five groups, namely negative control, positive control, Rhodomyrtus tomentosa leaf extract 15%, 30%, and 60%. Rhodomyrtus tomentosa leaf extraction was carried out by maceration method with 70% ethano solvent. The extraction results are divided into 3 concentrations (15%, 30% and 60%). The wound healing process was evaluated by measuring the length of the wound manually from 0 to 10 days in each group. Meanwhile, the number of fibroblast cells was calculated through hematoxylin eosin (HE) staining and observed using an Olympus CX41 microscope with a 10x magnification and objective lens magnification in 3 fields. Result: There was a significant difference in the reduction in wound length (p =< 0,000) between the five experimental groups (Rhodomyrtus tomentosa leaf extract solution 15%, 30% and 60%, negative control and positive control. Solution of rhodomyrtus tomentosa leaf extract accelerated the increase in the number of fibroblasts compared to the negative control group (p = 0.003), but did not make a difference (p = 0.403) with the positive control group. Rhodomyrtus tomentosa leaf extraction solution had the same microscopic effect on the number of fibroblasts with a positive control group given 0.9% NaCl solution. Conclusion: There was a significant difference in the number of fibroblasts between all groups, but no difference in wound healing length.

Cite this article:
Endang Sri Purwanti Ningsih, Noorlaila, Muhammad Ikhwan Rizki, Windy Yuliana Budianto. Potential Antiseptic of Rhodomyrtus tomentosa leaves extract on Healing wound in Male Wistar rats. Research Journal of Pharmacy and Technology. 2021; 14(6):3143-9. doi: 10.52711/0974-360X.2021.00548

Endang Sri Purwanti Ningsih, Noorlaila, Muhammad Ikhwan Rizki, Windy Yuliana Budianto. Potential Antiseptic of Rhodomyrtus tomentosa leaves extract on Healing wound in Male Wistar rats. Research Journal of Pharmacy and Technology. 2021; 14(6):3143-9. doi: 10.52711/0974-360X.2021.00548   Available on:

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