Author(s): Abha Shukla, Anchal Choudhary, Rishi Kumar Shukla, Amanpreet Kaur


DOI: 10.52711/0974-360X.2021.00512   

Address: Abha Shukla1, Anchal Choudhary1*, Rishi Kumar Shukla2, Amanpreet Kaur1
1Department of Chemistry, Kanya Gurukula Campus, Gurukula Kangri Vishwavidyalaya, Haridwar, Uttarakhand - 249407, India.
2Department of Chemistry, Gurukula Kangri Vishwavidyalaya, Haridwar, Uttarakhand - 249404, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021

Column chromatography of purified ethyl acetate extract of bark part of Boehmeria rugulosa afforded triterpenoids (3-oxo-20-demethylisoaleuritolic-28,29-dioic acid and 3-oxo-20-demethylisoaleuritolic-28,30-dioic acid.). Structure of these compounds was elucidated using spectroscopic techniques. This is the first report of isolation of this compound from bark of B. rugulosa.

Cite this article:
Abha Shukla, Anchal Choudhary, Rishi Kumar Shukla, Amanpreet Kaur. Isolation and Identification of two Triterpenoids from Ethyl acetate extract of Bark of Boehmeria rugulosa. Research Journal of Pharmacy and Technology. 2021; 14(6):2919-3. doi: 10.52711/0974-360X.2021.00512

Abha Shukla, Anchal Choudhary, Rishi Kumar Shukla, Amanpreet Kaur. Isolation and Identification of two Triterpenoids from Ethyl acetate extract of Bark of Boehmeria rugulosa. Research Journal of Pharmacy and Technology. 2021; 14(6):2919-3. doi: 10.52711/0974-360X.2021.00512   Available on:

1.    Kumar A, Patil D, Rajamohanan PR, Ahmad A. Isolation, Purification and Characterization of Vinblastine and Vincristine from Endophytic Fungus Fusarium oxysporum Isolated from Catharanthus roseus. PLOS ONE. 8(9); 2013: 1-10.
2.    Arirudran B. Krishnan V. Mahadeva Rao Us. Preliminary Phytochemical Analysis and Isolation and Identification of active principle components of petroleum ether extract from leaves of Lawsoniainermis L. Research Journal of Pharmacy and technology. 12(8); 2019: 3626-3636.
3.    Chin YW, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery from natural sources. The AAPS Journal. 8(2); 2006: 239-53.
4.    Kolekar SM, Jain BU, Kondawarkar MS. A Review on Steroids and Terpenoids (Stereochemistry, Structural Elucidation, Isolation of Steroids and Terpenoids). Research Journal of Pharmaceutical Dosage Forms and Technology. 11(2); 2019: 126-30.
5.    Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. The Lancet Neurology. 10(9); 2011: 819-28.
6.    Dumont M, Wille E, Calingasan NY, Tampellini D, Williams C, Gouras GK, Liby K, Sporn M, Flint Beal M, Lin MT. Triterpenoid CDDO‐methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease. Journal of Neurochemistry. 109(2); 2009: 502-12.
7.    Zhang X, Wu J, Dou Y, Xia B, Rong W, Rimbach G, Lou Y. Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. European Journal of Pharmacology. 679(1-3); 2012: 51-9.
8.    Sukrasno. Changes in Secondary Metabolite Contents Following Crude Drug Preparation. Procedia Chemistry. 13; 2014: 57–62.
9.    Delgoda R, Murray JE. Evolutionary Perspectives on the Role of Plant Secondary Metabolites. Fundamentals, Applications and Strategies. 2017: 93-100.
10.    Al-Shamma A, Drake SD, Guagliardi LE, Mitscher LA, Swayze JK. Antimicrobial alkaloids from Boehmeria cylindrica. Phytochemistry. 21(2); 1982: 485-7.
11.    Luo YG, Li BG, Zhang GL. A new quinolizidine alkaloid from Boehmeria siamensis. Chinese Chemical Letters. 12(4); 2001: 337-8.
12.    Cai XF, Jin X, Lee D, Yang YT, Lee K, Hong YS, Lee JH, Lee JJ. Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells. Journal of Natural Products. 69(7); 2006: 1095-7.
13.    Li W, Ding L, Li B. Chemical constituents of the root of Boehmeira nivea (L.) Gaud. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China Journal of Chinese Materia Medica. 21(7); 1996: 427-8.
14.    Semwal DK, Rawat U, Semwal R, Singh R, Krishan P, Singh M, Singh GJ. Chemical constituents from the leaves of Boehmeria rugulosa with antidiabetic and antimicrobial activities. Journal of Asian Natural Products Research. 11(12); 2009: 1045-55.
15.    Yan J, Luo D, Luo Y, Gao X, Zhang G. Induction of G1 arrest and differentiation in MDA-MB-231 breast cancer cell by boehmeriasin A, a novel compound from plant. International Journal of Gynecologic Cancer. 16(1); 2006: 165-70.
16.    Huang KL, Lai YK, Lin CC, Chang JM. Inhibition of hepatitis B virus production by Boehmeria nivea root extract in HepG2 2.2. 15 cells. World Journal of Gastroenterology: WJG. 12(35); 2006: 5721.
17.    Pereira de Paiva P, Regina Nonato F, Lúcia Tasca Gois Ruiz A, Maria de Oliveira Sousa I, Teixeira Zafred RR, Noin de Oliveira D, Catharino RR, Ann Foglio M, De Carvalho JE. An Ethanolic Extract of Boehmeria caudata Aerial Parts Displays Anti-Inflammatory and Anti-tumor Activities. 7; 2020: 17–25.
18.    Shukla, A., Choudhary, A. 2018. Evaluation of in vitro antidiabetic and anti-inflammatory activities of leaves extract of Boehmeria rugulosa. Asian Journal of Pharmaceutical and Clinical Research. 11(9), 200-203.
19.    Shukla, A., Choudhary, A., Shukla, R. K. Shukla. 2019. Studies on Physico-chemical Characteristics, Heavy Metals and Minerals components of leaves of Boehmeria rugulosa Wedd. Research Journal of Pharmacy and Technology. 12(5), 2093-2097.
20.    Viswanathan, V., Mukne, A. P. Development and Validation of HPLC and HPTLC Methods for Estimation of Glabridin in Extracts of Glycyrrhiza Glabra. J AOAC Int. 99(2); 2016: 374-9
21.    Ollengo MA, Vulule JM, Matasyoh JC. Isolation, Structure Elucidation and Larvicidal Activity of Laggera alata Extracts. Res J Pharm Phytochem. 8(3); 2016: 153-64.

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