Author(s): P. V. Kamala Kumari, Y. Srinivasa Rao, S. Akhila, K. Bhavya Sindhu

Email(s): kamalaparavastu@gmail.com

DOI: 10.52711/0974-360X.2021.00521   

Address: P. V. Kamala Kumari*, Y. Srinivasa Rao, S. Akhila, K. Bhavya Sindhu
Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Near Kapujaggarajupeta, Duvvada, Visakhapatnam, Andhra Pradesh-530049.
*Corresponding Author

Published In:   Volume - 14,      Issue - 6,     Year - 2021


ABSTRACT:
Drug delivery in conventional dosage forms often suffers from the drawbacks of repeated drug administration and large fluctuations in blood drug levels. Controlled drug delivery systems are a convenient way of controlling the dosing frequency responsible for rapid absorption and distribution of drug in conventional dosage forms, and are dependent upon two intrinsic properties of the drug, namely, elimination half-life (t1/2) and therapeutic index (TI). The goal is to give a drug at a sufficient rate, frequency and dose so that the ratio Cmax/Cmin in plasma at steady state is always maintained at effective concentrations during the course of therapy, reducing side effects or improving physicochemical and biopharmaceutical properties. The use of polymers provides the potential to control drug delivery both temporally and spatially. The objective of the present investigation was to develop bilayered tablets of orlistat to achieve controlled release and immediate release. The process is predetermined in such a way to release the drug at an IR and CR by using different polymers. Half life of orlistat is 1-2 hrs, as it has been released immediately. This paper mainly focuses on designing the process to release the drug in a controlled manner by using different polymers like sodium alginate, ethyl cellulose, HPMC.


Cite this article:
P. V. Kamala Kumari, Y. Srinivasa Rao, S. Akhila, K. Bhavya Sindhu. Design and Characterization of Orlistat Bilayered controlled release Tablets. Research Journal of Pharmacy and Technology. 2021; 14(6):2976-2. doi: 10.52711/0974-360X.2021.00521

Cite(Electronic):
P. V. Kamala Kumari, Y. Srinivasa Rao, S. Akhila, K. Bhavya Sindhu. Design and Characterization of Orlistat Bilayered controlled release Tablets. Research Journal of Pharmacy and Technology. 2021; 14(6):2976-2. doi: 10.52711/0974-360X.2021.00521   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-6-11


REFERENCES:
1.    Tsutsumi K. Lipoprotein lipase and atherosclerosis. Current Vascular Pharmacology. 2003 ;1(1): 11-7.
2.    Asija Rajesh, Bansal Vishnu, Asija Sangeeta, Rathore Suryabhan Singh. Matrix Tablet: A Promising Tool for Oral Controlled Release Drug Delivery. Asian J. Pharm. Res.2013; 3(4): 213-219.
3.    Mercy Mathew, Ravikumar, Simila Madathil, Anju Govind, Narayana Swamy VB. Formulation and Evaluation of Cinitapride Controlled Release Tablets. Asian J. Pharm. Res. 2016; 6(2): 87-94.
4.    Niyaz Kavugoli, Ravikumar, Narayanaswamy VB. Formulation and Evaluation of Controlled Release Matrix Tablets of Labetalol HCl. Asian J. Pharm. Res. 2016; 6(2): 107-120.
5.    Al-Suwailem K, Al-Tamimi S, Al-Omar MA, Al-Suhibani MS. Safety and mechanism of action of orlistat (tetrahydrolipstatin) as the first local antiobesity drug. J Appl Sci Res 2006;2: 205-8
6.    Sanghavi S, Polara M, Patel M, Patel J, Shah N. Bilayer Tablets–A Review of State of Art. Research Journal of Pharmaceutical Dosage Forms and Technology. 2012;4(3): 160-5
7.    Smita S. Aher, Poonam R. Songire, Ravindra B. Saudagar. Formulation and Evaluation of Controlled Release Matrix Tablet of Albuterol Sulphate. Asian J. Res. Pharm. Sci. 2016; 6(4): 223-229.
8.    Poonam R. Songire, Smita S. Aher, R. B. Saudagar. Recent Research on Matrix Tablets for Controlled Release – A Review. Asian J. Pharm. Tech. 2015; Vol. 5( 4): 214-221.
9.    Bougoulia M, Triantos A, Koliakos G. Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women. Hormones (Athens) 2006; 5: 259-69.
10.    Patel RN, Bharadia PD. Formulation and evaluation of dual component tablets of metoprolol tartrate. Int J Pharm Chem Sci 2012;1: 514-22.
11.    Bhise K, Shaikh S, Bora D. Taste mask, design and evaluation of an oral formulation using ion exchange resin as drug carrier. AAPS Pharm sci tech. 2008;9(2): 557-62.
12.    Indian Pharmacopoeia. Uniformity of weight of single-dose preparations. Ghaziabad: The Indian Pharmacopoeia Commission, Central Indian Pharmacopoeia Laboratory, Govt. of India, Ministry of Health & Family Welfare, 2008. p.182.
13.    Indian Pharmacopoeia. Friability of uncoated tablets. Ghaziabad: The Indian Pharmacopoeia Commission, Central Indian Pharmacopoeia Laboratory, Govt. of India, Ministry of Health and Family Welfare, 2008. p.183.
14.    Banker, G.S.; Anderson, N.R. Tablets. In: Lachman, L.; Lieberman, H. (Eds.). The theory and practice of industrial pharmacy. New Delhi: CBS Publishers and Distributors, 2009. p.293-345
15.    Indian Pharmacopoeia. Uniformity of content of single-dose preparations. Ghaziabad: The Indian Pharmacopoeia Commission, Central Indian Pharmacopoeia Laboratory, Govt. of India, Ministry of Health and Family Welfare, 2008. p.182.
16.    Asha Begum, B. Bhargavi, J. Divya, K. Swetha, Sk. Zareena, Lohitha S, Ramya Sri S. Formulation and In Vitro Characterisation Oxcarbazepine Controlled Release Tablets. Asian J. Pharm. Tech. 2019; 9(2): 107-111
17.    Krishna Reddy, K. Giri. Preparation and In vitro Characterisation Venlafaxine HCl Controlled Release Tablets. Asian J. Pharm. Tech. 2020; 10(2): 81-84.
18.    Bettini R, Catellani PL, Santi P, Massimo G, Peppas NA, Colombo P. Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. Journal of Controlled Release. 2001;70(3): 383-91.
19.    Lazarus J, Cooper J. Absorption, testing, and clinical evaluation of oral prolonged-action drugs. Journal of Pharmaceutical Sciences. 1961;50(9): 715-32.
20.    Vinod R, Ashok Kumar P, Amit S Yadav, Someshwara Rao B , Suresh V Kulkarni. Formulation and Evaluation of Controlled Release Microspheres of Zidovudine. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1): 96-99
21.    Wagner JG. Interpretation of percent dissolved‐time plots derived from in vitro testing of conventional tablets and capsules. Journal of Pharmaceutical Sciences. 1969; 58(10): 1253-7.
22.    Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. International Journal of Pharmaceutics. 1983;15(1): 25-35.
23.    Ravindra Babu Baggi, Naveen Babu Kilaru. An Unified Mathematical Expression for Ideal Peppas Model: Prospective Estimation of percent deviation. Asian J. Pharm. Tech. 2016; 6 (3): 189-196.
24.    Ravindra Babu Baggi, Naveen Babu Kilaru. Modulation of drug release mechanism by Higuchi model: Estimation of percent deviation. Asian J. Pharm. Tech. 2016; 6(4): 249-256
25.    Peppas N. Analysis of Fickian and non-Fickian drug release from polymers. Pharmaceutica Acta Helvetiae. 1985; 60(4): 110-1.
26.    Kamel S, Ali N, Jahangir K, Shah SM, El-Gendy AA. Pharmaceutical significance of cellulose: a review. Express Polym Lett. 2008; 2(11): 758-78.
27.    Tahara K, Yamamoto K, Nishihata T. Overall mechanism behind matrix sustained release (SR) tablets prepared with hydroxypropyl methylcellulose 2910. Journal of Controlled Release. 1995; 35(1): 59-66.
28.    Alderman DA. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int J Pharm Tech Prod Mfr. 1984; 5(3): 1-9.
29.    Lee PI, Peppas NA. Prediction of polymer dissolution in swellable controlled-release systems. Journal of Controlled Release. 1987;6(1): 207-15.
30.    Johnson JL, Holinej J, Williams MD. Influence of ionic strength on matrix integrity and drug release from hydroxypropyl cellulose compacts. International Journal of Pharmaceutics. 1993; 90(2): 151-9.
31.    Lindner WD, Lippold BC. Drug release from hydrocolloid embeddings with high or low susceptibility to hydrodynamic stress. Pharmaceutical Research. 1995; 12(11): 1781-5.
32.    Skoug JW, Mikelsons MV, Vigneron CN, Stemm NL. Qualitative evaluation of the mechanism of release of matrix sustained release dosage forms by measurement of polymer release. Journal of Controlled Release. 1993; 27(3): 227-45.
33.    Sujja-Areevath J, Munday DL, Cox PJ, Khan KA. Relationship between swelling, erosion and drug release in hydrophillic natural gum mini-matrix formulations. European Journal of Pharmaceutical Sciences. 1998; 6(3): 207-17.
34.    Sunil SA, Srikanth MV, Rao NS, Balaji S, Murthy KV. Design and evaluation of lornoxicam bilayered tablets for biphasic release. Brazilian Journal of Pharmaceutical Sciences. 2012; 48(4): 609-19.

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Lakshmi Narasimha, A. Tamil Selvan, D. Jairam, R. Suthakaran

DOI: Not Available         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Vandana Devi Sahu, Mukta Agrawal, Mukesh Sharma, Sandhya Chandrakar, Sujata Gupta, Garima Sharma, Kalyani Dewangan, Harsha Solanki, Manisha Majumdar, D. K. Tripathi, Amit Alexander, Ajazuddin

DOI: 10.5958/0974-360X.2016.00145.1         Access: Open Access Read More

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Author(s): Muhammad Hamdan, Noorhamdani AS, Masruroh Rahayu, Mohammmad Hasan Machfoed

DOI: 10.5958/0974-360X.2019.01020.5         Access: Open Access Read More

Author(s): Jeganath. S, Asha. D, Sathesh Kumar. S, Keerthi S Nair, Senthil Kumaran. K

DOI: 10.5958/0974-360X.2018.00151.8         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Mouli Chandar. M Anton Smith. A

DOI: 10.5958/0974-360X.2019.00884.9         Access: Open Access Read More

Author(s): Vishali T, Damodharan N

DOI: 10.5958/0974-360X.2020.00449.7         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags