Author(s): Firoz S, Rajasekaran S

Email(s): firoz.kallur@gmail.com

DOI: 10.52711/0974-360X.2021.00506   

Address: Firoz S1*, Rajasekaran S2
1Research Scholar, Bhagwant University, Ajmer, Rajasthan. 2Department of Pharmacology, Malik Deenar College of Pharmacy, Kasaragod, Kerala.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
The concept of combination of thermo reversibility and mucoadhesion has achieved a much valuable interest in various fields of pharmaceutics. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. Thermoreversible gels are the hydrogels that are liquids at room temperature but undergo gelation when in contact with body fluids or change in pH. A major problem faced by conventional formulation in various routes of administration viz. nasal, ocular, vaginal, rectal, etc is drainage of instilled formulation, poor patient compliance as in the case of vaginal and rectal delivery system. Also, blurred vision and irritation to mucosa is observed in the case of ocular and nasal delivery respectively. The drainage of the formulation results in inaccurate dose delivery thus decreasing the bioavailability of the drug which demands an increase in the frequency of the administration. To overcome these limitations, there is need of novel delivery system such as thermoreversible mucoadhesive insitu gel which provides an ease of administration and improved patient compliance as these smart delivery system is free flowing liquid at ambient temperature and gels at physiological temperature which is higher than the LCST (low critical solution temperature) of thermoreversible polymer. The combined effect of mucoadhesion and thermoreversible property will enhance prolongation of residence time of dosage form and the accuracy of the dose in body cavity respectively, leading to increased bioavailability of the drug. This review focuses on benefits of mucoadhesive thermoreversible system of drug delivery through rectum for the treatment of internal hemorrhoids.


Cite this article:
Firoz S, Rajasekaran S. A Survey on Mucoadhesive Thermoreversible Drug Delivery System with special Emphasis on Recto-Anal Region for the Treatment of Internal Hemorrhoids. Research Journal of Pharmacy and Technology. 2021; 14(5):2878-6. doi: 10.52711/0974-360X.2021.00506

Cite(Electronic):
Firoz S, Rajasekaran S. A Survey on Mucoadhesive Thermoreversible Drug Delivery System with special Emphasis on Recto-Anal Region for the Treatment of Internal Hemorrhoids. Research Journal of Pharmacy and Technology. 2021; 14(5):2878-6. doi: 10.52711/0974-360X.2021.00506   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-90


REFERENCES:
1.    Shailesh H, Surajj S. Formulation and Evaluation of Mucoadhesive Tablet of Valsartan. Asian Journal of Pharmaceutical Research. 2019; 9(4): 229-237.
2.    Andrews G P, Laverty T P, and Jones D S. Mucoadhesive polymeric platforms for controlled drug delivery. European Journal of Pharmaceutics and Biopharmaceutics.2009; 71(3): 505–518.
3.    Vazir Ashfaq A, Shiv Kumar H G, Paranjothy K L K. In-Situ Gel Forming Ophthalmic Drug Delivery System. Research Journal of Pharmacy and Technology. 2009; 2(1):123-127.
4.    Sarada K, Firoz S, Padmini K. In-Situ Gelling System: A Review. International Journal of Current Pharmaceutical Review and Research. 2015; 5(4): 76-90.
5.    Nirmal HB, Bakliwal SR, Pawar SP. In-Situ gel: New trends in Controlled and Sustained Drug Delivery System. International Journal of Pharm Tech Research. 2010; 2(2): 1398-1408.
6.    Kumar L. An Overview on Preparation and Evaluation of Microparticulated Intra-Vaginal Gel. Research Journal of Pharmacy and Technology. 2009; 2(1): 48-51.
7.    Lakshmi Prasanna J, Deepthi B, Rama Rao N. Rectal drug delivery: A promising route for enhancing drug absorption. Asian Journal of Research in Pharmaceutical Sciences. 2012; 2(4): 143-149.
8.    De Boer A G. Rate controlled rectal peptide absorption enhancement in Penetration enhancement for polypeptides through Epithelia. Advanced Drug Delivery Reviews. 1992; 8(3): 237-253.
9.    Saleem M A, Taher M, Sanaullah S, Najmuddin M, Javed A, Humaira A, Roshan S. Formulation and Evaluation of Tramadol hydrochloride Rectal Suppositories. Indian Journal of Pharmaceutical Sciences. 2008, 640-644.
10.    Singh S, Kanupriya, Harikumar. Intranasal thermoreversible mucoadhesive gels: a review. International Journal of Pharmacy. 2012; 2: 548-556.
11.    Saudagar R B, Sarika V. In-Situ Nasal Gel- A Review. Asian Journal of Research in Pharmaceutical Sciences.2017; 7(1): 23-32.
12.    Moolenaar F. Drastic improvement in the rectal absorption profile of Morphine in man. European Journal of clinical pharmacology.1985; 29(1): 119-121.
13.    Patel Geeta M, Patel Madhabhai M. Vagina: An Ideal Site for Drug Delivery. Research Journal of Pharmacy and Technology. 2009; 2(1): 426-432.
14.    Jorge J M, Wexner S D. Anatomy and physiology of the rectum and anus. Eur J Surg. 1997; 163(10): 723-31.
15.    https://emedicine.medscape.com/article/775407-overview.
16.    Sonal C. Bankhele, Rupali B. Harale, Monica R P Rao, Madhura V. Dhoka*. Thermoreversible In-Situ Ophthalmic Gelling System of Levofloxacin Hemihydrate: Formulation and Optimization by Factorial Design. Asian Journal of Pharmaceutical Research.2012; 2(3): 100-106.
17.    Nisha B.Prajapati and Anju Goyal. Thermoreversible Mucoadhesive Insitu Gel: A Review. International Journal of Innovative Drug Discovery. 2013; 3(2): 67-84.
18.    Sharma N, Sharma A, Sharma P. Mucoadhesive thermoreversible nasal delivery system. Journal of Pharmacy Research. 2010; 3: 991-997.
19.    Patil S, Murthy R, Mahajan H. Mucoadhesive polymers: Means of improving drug delivery. Pharma Times. 2006; 38: 25-28.
20.    Majithiya R, Ghosh P, Umrethia M, Murthy R. Thermoreversible-mucoadhesive gel for nasal delivery of sumatriptan. AAPS pharm. Sci. Tech. 2006,7.
21.    Shinde K, Mali K, Dias R. Insitu mucoadhesive nasal gels of Metoclopramide hydrochloride: Preformulation and formulation studies. Journal of Pharmacy Research. 2008; 1: 88-96.
22.    Chaudhari S, Bhise P, Lahane A, Misra M.Formulation and evaluation of thermoreversible mucoadhesive microemulsion based in-situ gel of an anti-osteoporotic agent. Journal of Global Pharma Tech. 2010; 2: 43-47.
23.    Rawat S, Warde S, Lahoti S. Insitu gel formulation of Ornidazole for the treatment of periodontal disease. Current Pharma Research. 2010;1: 60-69.
24.    Patel M, Thakkar H, Kasture P. Preparation and evaluation of Thermoreversible formulations of Flunarizine hydrochloride for nasal delivery. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2: 116-120.
25.    Ankit A, Prakash G, Vinay C H. Determination of Mucoadhesive behaviour of Timolol maleate liquid crystalline cubogel by different Techniques. Asian Journal of Pharmaceutical Research.2019; 9(1): 07-11.
26.    Wagh P K, Ahirrao S P, Kshirsagar S J. Novel Mucoadhesive Gastro Retentive Drug Delivery System of Ranitidine Hydrochloride. Asian Journal of Pharmaceutical Research. 2019; 9(2): 80-86.
27.    Manmohan S.Anshita G, Abhishek K. Development and Evaluation of Mucoadhesive Sustained Release Tablet using Tamarindus indica Gum. Asian Journal of Research in Pharmaceutical Sciences. 2014; 4(2): 77-82.
28.    Vijay H, Remeth J, Kailas K, Vishwajeet G. Rectal suppository as an effective alternative for oral administration. Research Journal of Pharmacy and Technology, 2015; 8(6): 759-766.

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): R. Narayana Charyulu, P. Parvathy Devi, Jobin Jose, A. Veena Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Prasad V. Patrekar, Sachin S. Mali

DOI: Not Available         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

Author(s): S. R Suseem, Dhanish Joseph

DOI: 10.5958/0974-360X.2019.00067.2         Access: Open Access Read More

Author(s): Kalpana Kamnoore, M P Venkatesh, Balamuralidhara V, T M Pramod Kumar

DOI: 10.5958/0974-360X.2020.00276.0         Access: Open Access Read More

Author(s): Sunanda Rao, Lakshmi T.

DOI:         Access: Open Access Read More

Author(s): Justin Antony, Satadal Debroy, Chennu Manisha, Peet Thomas, Victoria Jeyarani, Tenzin Choephel

DOI: 10.5958/0974-360X.2019.00367.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags