Author(s): Ratnaparkhi M.P., Karnawat G.R., Andhale R.S.


DOI: 10.52711/0974-360X.2021.00503   

Address: Ratnaparkhi M.P.*, Karnawat G.R., Andhale R.S.
Dept. of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon (Kalewadi), Pune - 411033 India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021

Oral route is most preferable route of administration for various drugs, because it is convenient, economical, safest route. Fast dissolving tablets are popular nowadays, as they disintegrated in mouth within a few seconds without using water for swallow. Problems like Dysphagia in pediatric and geriatric patients have been overcome by formulating Fast dissolving tablet. Natural polymers are preferable because they are chemically inert, nontoxic, less expensive, biodegradable, and available easily than synthetic polymers. Natural polymers are obtained from the natural origin so they are devoid of any side effect. It is proved from the previous studies that Natural polymers are more-safe and effective than the synthetic polymers. Natural polymers improve the properties of tablet and they are used as binder, diluent, superdisintegrant, they also enhance the solubility of poorly water-soluble drug, decrease the disintegration time and provide nutritional supplement. The aim of the present article is to study various natural polymers used in fast dissolving tablets.

Cite this article:
Ratnaparkhi M.P., Karnawat G.R., Andhale R.S.. Natural Polymers in Fast Dissolving Tablets. Research Journal of Pharmacy and Technology. 2021; 14(5):2859-6. doi: 10.52711/0974-360X.2021.00503

Ratnaparkhi M.P., Karnawat G.R., Andhale R.S.. Natural Polymers in Fast Dissolving Tablets. Research Journal of Pharmacy and Technology. 2021; 14(5):2859-6. doi: 10.52711/0974-360X.2021.00503   Available on:

1.    H. C. Ansel, N. G. Popvich, and L. V. Allen, Pharmaceutical Dosage Forms and Drug Delivery System, 1st edition, 1998.
2.    N. K. Jain and S. N. Sharma, A Text Book of Professional Pharmacy, 4th edition, 1998.
3.    Patel A, Prajapati DS, Raval JA, Fast Dissolving Films (Fdfs) As A Newer Venture In Fast Dissolving Dosage Forms, International Journal of Drug Development and Research, 2, 2010, 232-246.
4.    Kalyan S, Bansal M, Recent Trends In The Development of Oral Dissolving Film, International Journal of Pharmtech Research, 4, 2012, 725-733.
5.    Nagar M and Yadav AV: Cinnarizine orodispersible tablets: a Chitosan based fast mouth dissolving technology. International Journal of PharmTech Research 2009; 1(4): 1079-1091.
6.    Goel H, Tiwary AK, Rana V. Fabrication and optimization of fast disintegrating tablets employing interpolymeric chitosan-alginate complex and chitin as novel superdisintegrants. Acta Pol Pharm-Drug Res, 2011; 68(4): 571-583
7.    P. K. Lakshmi, D. Lavanya, M. M. Husnien Ali, Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films International Current Pharmaceutical Journal, February 2014, 3(3): 243-246
8.    Sunitha H S, S. Parthiban, A. Vikneshwiri, G.P. Senthil kumar, T. Tamiz Mani, evaluation of captopril fast disintegratingor dissolving tablets by complexation techniques using guargum as a superdisintegrant, International Journal of Research in Pharmaceutical and Nano Sciences. 4(2), 2015, 72 - 84.
9.    N. Bansaland G. Sharma. Formulation and Evaluation of Orally Disintegrating Tablets Of Ondansetron Hydrochloride Using Natural Superdisintegrants. International Journal of Pharmtech Research, IJPRIF. 2011:1616-1621.
10.    Shah B: Textbook of Pharmacognosy and Phytochemistry. Elsevier Health Sciences Publishers, First Edition 2009; 164-165.
11.    Bhowmik D, Chiranjib B, Yadav J, Chandira RM and Kumar S: Emerging trends of disintegrants used in formulation of solid dosage form. Scholars Research Library Der Pharmacia Lettre 2010; 2 (1): 495-504
12.    Himanshu Deshmkh, Chandrashekhara S., Nagesh C., Amol Murade, Shridhar Usgaunkar. Superdisintegrants: A Recent Investigation and Current Approach Asian J. Pharm. Tech. 2012; Vol. 2: Issue 1, Pg 19-25.
13.    Shailaja T, Latha K, Alkabab A M, Sasibhushan P, Uhumwangho M U, formulation and evaluation of orodispersible tablets of metoprolol tartrate with natural and synthetic superdisintegrants, International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Issue 3, 2012
14.    Kumar R, Patil S, Patil MB, Patil SR and Paschapur MS: Isolation and evaluation of disintegrant properties of Fenugreek seed mucilage. International Journal of PharmTech Research. 2009; 1(4): 982-996
15.    Sudheshnababu Sukhavasi, V. Saikishore, Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using Fenugreek seed mucilage and Ocimumbasilicumgum, International Current Pharmaceutical Journal. 2012, 1(9): 243-249
16.    Ashok Kumarsharma, Dr. Vandana Sharma, Shankarlal Soni, Ramesh Pareek, Rakeshkumar Goyal and Mohit Khandelwal, Formulation and evaluation of fast dissolving tablet of domperidone using fenugreek seed mucilage as natural superdisintegrant by direct compression method., volume 7, issue 2, 643-653.
17.    Sachin Gunjal, Kishor Salunkhe, Sandip Baviskar, Snehal Patil and Ritesh Karmarkar, Formulation, Development and Evaluation of Amlodipine Besylate orally Disintegrating Tablet Using Soy Polysaccharide as Novel Superdisintegrants , International Journal of Pharmaceutical and Chemical Sciences ISSN: 22775005
18.    Shah DP and Jani GK: A newer application of physically modified Gellan gum in tablet formulation using factorial design. ARS Pharmaceutica 2010; 51(1): 28-40.
19.    P. J. Antony and N. M. Sanghavi, “A new disintegrant for pharmaceutical dosage forms,” Drug Development and Industrial Pharmacy, vol. 23, no. 4, pp. 413–415, 1997
20.    Emeje, M. O., Franklin-Ude, P. I., and Ofoefule, S. I. (2010). Evaluation of the fluid uptake kinetics and drug release from gellan gum tablets containing metronidazole. International journal of biological macromolecules, 47(2), 158–163. Doi:10.1016/j.ijbiomac.2010.05.005
21.    R. Malviya, P. Srivastava, and G. T. Kulkarni, “Application of Mucilage’s and drug delivery: a review,” Advances in Biological Research, vol. 5, pp. 1–7, 2011.
22.    H. A. Liebermann, L. Lachman, and J. B. Schawstr, Pharmaceutical Dosage Forms Tablets, vol. 2, 1989
23.    Divekar VB, Kalaskar MG, Chougule PD, Redasani VK and Baheti DG: Isolation and characterization of mucilage from Lepidium sativum linn seeds. International Journal of Pharmaceutical Research and Development 2010; 2(1): 1-5.
24.    Mehta KK, Patel HH, Patel ND, Vora CN and Patel NJ: Comparative evaluation of natural and synthetic superdisintegrant for promoting Nimesulide dissolution for fast dissolving technology, International Journal of Pharmacy and Pharmaceutical Research 2010; 2; 102-108.
25.    Lovleen Kaur, Rajni Bala, Neha Kanojia, Manju Nagpal and Gitika Arora Dhingra, Formulation Development and Optimization of Fast Dissolving Tablets of Aceclofenac Using Natural Superdisintegrant, ISRN Pharmaceutics Volume 2014.
26.    B. S. Singh, “Pysllium as therapeutic and drug delivery agent” International Journal of Pharmaceutics, vol. 334, pp. 1–14, 2007.
27.    G. GokulGhenge, S. D. Pande, A. Ahmad, L. Jejurkar, and T.Birari, “Development and characterisation of fast disintegratingtablet of amlodipine besylate using mucilage of plantagoovata as a natural superdisintegrant, ” International Journal of PharmTech Research, vol. 3, no. 2, pp. 938–945, 2011.
28.    S. B. Shirsand, Sarasija Suresh, M. S. Para, P. V. Swamy and D. Nagendra kumar, Plantagoovata mucilage in the design of fast disintegrating tablets, Indian Journal of Pharmaceutical Sciences, - February 2009
29.    U. Kulkarni and N. G. R. Rao, “Design and development of Aceclofenac fast dissolving tablets by amorphous solid dispersion technique using modified Marmelos gum,” International Journal of Pharmaceutical Research and Development, vol. 3, no.6, pp. 201–210, 2011.
30.    K. Malik, G. Arora, and I. Singh, “Locust bean gum as superdisintegrant–formulation and evaluation of nimesulide orodispersible tablets, ” Polimery w Medycynie, vol. 41, no. 1, pp.17–28, 2011.
31.    Nayak RK, Patil SR, Patil BM, BhatMahalaxami. Evaluation of disintegrating properties of Mangifera indica gum. RGUHS J Pharm Sci 2011; 01(01): 11-21.
32.    Shah V and Patel R: Studies on mucilage from Hibuscus rosa-sinensis linn. as oral disintegrant. International Journal of Applied Pharmaceutics 2010; 2(1): 18-21.
33.    Halakatti PK, Omer S, Gulgannavar RS and Patwari PK: Formulation and evaluation of mouth disintegrating tablets of Famotidine by using Hibiscus rosa-sinensis mucilage and treated agar. International Journal of Research in Ayurveda and Pharmacy 2010; 1(2): 497-505
34.    L. Prabakaran and D. Sendhil, “Formulation development of patient friendly dosage form: all in one natural excipient as binder, diluent and disintegrant,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 3, supplement 2, pp. 97–102, 2011.
35.    Maniratna Nareda, Ashok Kumar Sharma, Siddharth Nareda, Madhavi Ghadge, Dr. Shiv Garg and Dr. Piush Sharma, Design and Formulation of Fast Dissolving Tablet of Lornoxicam using Banana Powder as Natural superdisintegrant by direct compression method, WJPPS, Volume 7, Issue 2, 631-642
36.    P. R. Rai, A. K. Tiwary and V. Rana. Superior disintegrating properties of calcium cross-linked Cassia fistula gum derivatives for fast dissolving tablets. Carbohydrate Polymers.2012, 87, 1098–1104 doi:10.1016/j.carbpol.2011.08.050
37.    Malviya R, Srivastava P, Bansal M and Sharma PK: Preparation and evaluation of disintegrating properties of Cucurbita maxima pulp powder. International Journal of Pharmaceutical Sciences 2010; 2(1): 395-399.
38.    Patel D M, Prajapati D G, Patel N M Seed mucilage of Ocimumamericanumlinn. As disintegrate in tablet: separation and evaluation. Ind Journal of Pharmaceutical Sci. 2007; 69 (3):431-435.
39.    Khaled M Hosny, Ahmed Khames and Seham S Abd Elhady, Preparation and Evaluation of Orodispersible Tablets Containing Hydroxylbutyl-β-Cyclodextrin-Simvastatin Solid Dispersion August 2013; 12 (4): 469-476
40.    Shery Jacob, rosin microspheres as taste masking agent in oral drug delivery system, IJPSR, 2012; Vol. 3(9): 3116-3124
41.    Kelvin Bucktowar, MiliBucktowar, Luchmee Devi Bholoa, A Review on Sweet Basil Seeds: Ocimum basilicum, WJPPS, Volume 5, Issue 12, 554-567.
42.    F. J. Sayyad and Sfurti S. Sakhare, Isolation, Characterization and Evaluation of OcimumBasilicum Seed Mucilage for Tableting Performance, Indian J Pharm Sci 2018; 80(2):282-290.
43.    Sai. P. Bolla, S. Segji, Vinod. N, Voleti V. Kumar, Dr. C. Madhusudhan Chetty, Formulation and Evaluation of Orodispersible Tablets of Clonazepam using Natural Superdisintegrants. IOSR-JPBS Volume 9, Issue 4 Ver. I (Jul -Aug. 2014), PP 47-52.
44.    Ayesha Fatima and Sirisha Mittapally. Formulation and evaluation of mouth dissolving tablets of amiodarone (I.P), WJPPS Volume 6, Issue 9, 1054-1070.
45.    Ahmad Zaki, Effionoraanwa, Silviasurini. Formulation of a fast-disintegrating tablet using maltodextrin de 10-15 and pregelatinizated cassava starch as excipients, Int J App Pharm, Vol 9, Suppl 1, 2017.
46.    Kwang Hyeon Kim, Jun-Bom Park, Joo-Hyung Kang, Kun-Hee Lee and Chin-Yang Kang, Formulation and Evaluation of Sustained Release Preparation of Ibuprofen Fast-Disintegrating Tablet (FDT), Journal of Pharmaceutical Investigation Vol. 41, No. 1, 51-57 (2011) 51.
47.    Baginda Sati Pituanan, Silviasurini, Fast-disintegrating tablet formulation of ginger (Zingiber officinale Rosc.) Extract using coprocessed excipient of pre-gelatinized cassava starch-acacia gum, International Journal of Applied Pharmaceutics, 9, 154-158.
48.    Jha, A., and Chetia, D. (2012). Development of natural gum based fast disintegrating tablets of glipizide. Asian Journal of Pharmaceutics. 6(4), 282.
49.    Dos Santos, M. A., and Grenha, A. (2015). Polysaccharide Nanoparticles for Protein and Peptide Delivery. Protein and Peptide Nanoparticles for Drug Delivery, 223–261.
50.    Dinge, A., and Nagarsenker, M. (2008). Formulation and Evaluation of Fast Dissolving Films for Delivery of Triclosan to the Oral Cavity. AAPS Pharm Sci Tech, 9(2), 349–356.

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