Author(s): S. Preethi, S. Padmapriya, A. N. Rajalakshmi

Email(s): sppriya11@yahoo.co.in

DOI: 10.52711/0974-360X.2021.00498   

Address: S. Preethi, S. Padmapriya*, A. N. Rajalakshmi
College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
The study was aimed to formulate and evaluate dispersible tablets of a model anti-parasitic drug (XXX) with an objective to produce fast dispersion of tablets by reducing the disintegration time using three superdisintegrants like Sodium Starch Glycolate (SSG), Crospovidone (PVP K30) and Croscarmellose sodium (CCS) and also diluents namely MCC and Lactose by changing their concentrations in each formulations. Totally six formulations (F1-F6) were prepared by direct compression method and evaluated for hardness, thickness, weight variation, friability, wetting volume, wetting time, water absorption ratio, uniformity of dispersion, in-vitro disintegration time, Drug content, in-vitro dissolution test and release kinetics study. FTIR studies was carried out to see possible drug excipients interaction. The stability studies were performed as per ICH guidelines. Among the formulations F6 formulation was found to be promising as it showed better results than other five formulations with In-vitro disintegration time, percentage drug release and dispersion time of 16 ± 0.93 seconds, 98.32±0.54% and 66±1.30 seconds respectively. Further the FTIR results revealed that there was no interactionF between drug and excipients. Stability study of formulation showed no significant changes in tablet properties and the drug follows Higuchi release kinetics with Fickian diffusion mechanism.


Cite this article:
S. Preethi, S. Padmapriya, A. N. Rajalakshmi. Formulation and Evaluation of Dispersible tablets of a Model Anti-Parasitic Drug. Research Journal of Pharmacy and Technology. 2021; 14(5):2824-8. doi: 10.52711/0974-360X.2021.00498

Cite(Electronic):
S. Preethi, S. Padmapriya, A. N. Rajalakshmi. Formulation and Evaluation of Dispersible tablets of a Model Anti-Parasitic Drug. Research Journal of Pharmacy and Technology. 2021; 14(5):2824-8. doi: 10.52711/0974-360X.2021.00498   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-82


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