The study was aimed to formulate and evaluate dispersible tablets of a model anti-parasitic drug (XXX) with an objective to produce fast dispersion of tablets by reducing the disintegration time using three superdisintegrants like Sodium Starch Glycolate (SSG), Crospovidone (PVP K30) and Croscarmellose sodium (CCS) and also diluents namely MCC and Lactose by changing their concentrations in each formulations. Totally six formulations (F1-F6) were prepared by direct compression method and evaluated for hardness, thickness, weight variation, friability, wetting volume, wetting time, water absorption ratio, uniformity of dispersion, in-vitro disintegration time, Drug content, in-vitro dissolution test and release kinetics study. FTIR studies was carried out to see possible drug excipients interaction. The stability studies were performed as per ICH guidelines. Among the formulations F6 formulation was found to be promising as it showed better results than other five formulations with In-vitro disintegration time, percentage drug release and dispersion time of 16 ± 0.93 seconds, 98.32±0.54% and 66±1.30 seconds respectively. Further the FTIR results revealed that there was no interactionF between drug and excipients. Stability study of formulation showed no significant changes in tablet properties and the drug follows Higuchi release kinetics with Fickian diffusion mechanism.
Cite this article:
S. Preethi, S. Padmapriya, A. N. Rajalakshmi. Formulation and Evaluation of Dispersible tablets of a Model Anti-Parasitic Drug. Research Journal of Pharmacy and Technology. 2021; 14(5):2824-8. doi: 10.52711/0974-360X.2021.00498
S. Preethi, S. Padmapriya, A. N. Rajalakshmi. Formulation and Evaluation of Dispersible tablets of a Model Anti-Parasitic Drug. Research Journal of Pharmacy and Technology. 2021; 14(5):2824-8. doi: 10.52711/0974-360X.2021.00498 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-82
1. Abrescia FF, Falda A, Caramaschi G, Scalzini A, Gobbi F, Angheben A, Gobbo M, Schiavon R, Rovere P, Bisoffi Z. Reemergence of strongyloidiasis, Northern Italy. Emerg Infect Dis. 2009; 15: 1531–1533.
2. Hannan PA, Khan JA, Khan A, Safiullah S. Oral Dispersible System: A New Approach in Drug Delivery System. Indian J Pharm Sci, 2016; 78(1): 2–7.
3. Rasenak N, Muller BW. Crystal Habit and Tableting Behaviour. Int J Pharm, 2002; 244: 45-57.
4. Patidar A, Mishra P, Main P, Harsoliya MS, Agarwal S. A Review on Recent Advancement in the Development of Rapid Disintegrating Tablet. International Journal of Life Science and Pharma Research. 2011; 1(1): 7-16.
5. Rasenak N, Muller BW. Crystal Habit and Tableting Behaviour. Int J Pharm, 2002; 244: 45-57.
6. Kulkarni SV, Kumar RP, Patel N, Rao SB, Ramesh B, Kumar AP. Formulation and Evaluation of Fast Disintegrating Meloxicam Tablets and its comparison with Marketed Product. Int J Drug Delivery Technol. 2010; 2(2): 42-6.
7. Jadhav SB, Kaudewar DR, Kaminwar GS, Jadhav AB, Kshirsagar RV, Sakarkar DM. Formulation and Evaluation of Dispersible tablets of Diltiazem Hydrochloride. Int J Pharm Tech Res. 2011; 3(3): 131-21.
8. Shahi SR, Agrawal GR, Shinde NV, Shaikh SA, Shaik SS, Somani VG, Shamkuvarand PB, Kale MA: Formulation and In Vitro Evaluation of Oro-Dispersible Tablets of Etoricoxib with Emphasis on Comparative Functionality Evaluation of Three Classes of Superdisintegrants. Rasayan J. Chem 2008; 1(2); 292-300.
9. Shoukri RA, Ahmed IS, Rehab N. Shamma RN: In vitro and in vivo evaluation of nimesulide lyophilized orally disintegrating tablets. European Journal of Pharmaceutics and Biopharmaceutics 2009; 73: 162–171.
10. Subramanian S, Sankar V, Manakadan AA, Ismailand S, Andhuvan G: Formulation and evaluation of cetirizine dihydrochloride orodispersible tablet. J. Pharm. Sci April 2010: 239(2). 232-235.