Author(s): Diana Holidah, Ika Puspita Dewi, Fransiska Maria Christianty, Noer Sidqi Muhammadiy, Nur Huda

Email(s): diana.farmasi@unej.ac.id

DOI: 10.52711/0974-360X.2021.00494   

Address: Diana Holidah*, Ika Puspita Dewi, Fransiska Maria Christianty, Noer Sidqi Muhammadiy, Nur Huda
Department of Pharmacy Clinic and Community, Faculty of Pharmacy, University of Jember.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Diabetes mellitus is a syndrome due to disorders of carbohydrate, lipid, and protein metabolism due to decreased insulin secretion or reduced insulin sensitivity. The number of people with diabetes mellitus is increasing every year. However, diabetes mellitus is a major cause of cardiovascular disease, blindness, kidney failure, and amputation due to gangrene. Patients with diabetes mellitus have a possibility of 2-3 times higher cardiovascular disease than non diabetic. Sappan wood containing brazilin that have antioxidant activity and had a potential activity to lower the incidence of type 2 diabetes mellitus. Objective of this research was to determine the activity of secang wood extract as an antidiabetic and antidyslipidemic on diabetic rat. Diabetic rat induced by alloxan and given extract once daily for 14 days. At 15th day, blood glucose level, lipid profile was determine, pancreas was harvested and processed to hystopathological examination. Secang wood extract decreased blood glucose, cholesterol, triglyceride, and LDL level, increase HDL level, and repair the histology of pancreas on diabetic rat after 14 days treatment. Based on the result, secang wood extract had antidiabetic and antidyslipidemic activity on diabetic rat.


Cite this article:
Diana Holidah, Ika Puspita Dewi, Fransiska Maria Christianty, Noer Sidqi Muhammadiy, Nur Huda. Antidiabetic and Antidyslipidemic activity of Secang, (Caesalpinia sappan L.) Wood extract on Diabetic Rat. Research Journal of Pharmacy and Technology. 2021; 14(5):2801-6. doi: 10.52711/0974-360X.2021.00494

Cite(Electronic):
Diana Holidah, Ika Puspita Dewi, Fransiska Maria Christianty, Noer Sidqi Muhammadiy, Nur Huda. Antidiabetic and Antidyslipidemic activity of Secang, (Caesalpinia sappan L.) Wood extract on Diabetic Rat. Research Journal of Pharmacy and Technology. 2021; 14(5):2801-6. doi: 10.52711/0974-360X.2021.00494   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-78


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