Author(s): Pamula Reddy Bhavanam, Shaik Abdul Rahaman, M Mohan Varma

Email(s): pamula1114@gmail.com

DOI: 10.52711/0974-360X.2021.00488   

Address: Pamula Reddy Bhavanam1*, Shaik Abdul Rahaman1, M Mohan Varma2
1Department of Pharmaceutical Technology, Nirmala College of Pharmacy, Atmakuru, Andhra Pradesh - 522503, India.
2Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh - 534202, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Tamarind seed polysaccharide (TSP) micro sized mouth dissolving films were prepared to release the Amlodipine besylate drug for hypertension. TSP mouth dissolving films were prepared by solvent evaporation method which was further examined under in vitro studies. In vitro antimicrobial activities for all the mouth dissolving films were conducted by diffusion method. Form the in vitro release profile, the AML-TSP was completely showed rapid release of drug up to 98.1% than the thin films of other formulations respectively in the period of time of 10 min. The prepared AML-TSP mouth dissolving films were evaluated for drug content, weight variation, thickness, pH, folding endurance, In vitro drug release and stability studies. AML8 showed the highest drug release at the 10 min time point. The AML8 mouth dissolving film with higher amount of superdisintegrant CCS and SSG showed fastest onset of drug release.


Cite this article:
Pamula Reddy Bhavanam, Shaik Abdul Rahaman, M Mohan Varma. Tamarind Seed Polysaccharide Mouth Dissolving films for rapid drug Release in the treatment of Hypertension: In vitro Evaluation. Research Journal of Pharmacy and Technology. 2021; 14(5):2771-3. doi: 10.52711/0974-360X.2021.00488

Cite(Electronic):
Pamula Reddy Bhavanam, Shaik Abdul Rahaman, M Mohan Varma. Tamarind Seed Polysaccharide Mouth Dissolving films for rapid drug Release in the treatment of Hypertension: In vitro Evaluation. Research Journal of Pharmacy and Technology. 2021; 14(5):2771-3. doi: 10.52711/0974-360X.2021.00488   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-72


REFERENCES:
1.    Chatterjee CC. Human Physiology.  Published by Medical Allied Agency, Calcutta. 1985; 10: 427-434.
2.    Hiroshi Y, Takehikosuzuki, Masakazu M, Kazuo Noda, Masa YS. In situ Perfusion System for Oral Mucosal Absorption in Dogs. Journal of Pharmaceutical Sciences. 1990; 79 (11) : 4.
3.    Applied Biopharmaceutics and Pharmacokinetics. Edited by Leon Sharjeel, Andrew Yu, Published by Library of Congress. Cataloging in Publication Data. 1998; 4: (109, 156).
4.    Nishimura M, Matsuura K, Tsukioka T, Yamashita H, Inagaki N, Sugiyama T, Itoh Y. In vitro and in vivo characteristics of prochlorperazine oral disintegration film. Int. J. Pharm.2009; 368: 98-102.
5.    Sakuda Y, Ito A, Sasatsu M, Machida Y. Preparation and evaluation of medical carbon oral films. Chem. Pharm. Bull. 2010; (58) :454-457.
6.    Seager H. Drug delivery products and the zydis fast dissolving dosage forms. J. Pharm. Pharmacol, 1998; 50 (4): 375-82.
7.    Mashru R C, Sutariya V B, Sankalia M G, and Parikh P P. Development and evaluation of fast dissolving films of salbutamol sulphate. Drug develop. Ind. Pharm, 2005; 31(1): 25-34.
8.    Kunte S and Tandale P. Fast dissolving strips: A novel approach for the delivery of verapamil. J Pharm Bioallied Sci. Oct-Dec, 2010; (4): 325-328.
9.    Proteins. In: D.S.Hsieh (Ed.), Drug Permeation Enhancement. Theory and Applications, Aungst A, Permeability and metabolism as barriers to transmucosal delivery of peptides and Marcel Dekker, New York, 1994; 323-343.
10.    Batchelor H, Novel bioadhesive formulations in drug delivery, The Drug Delivery Companies Report Autumn/Winter, Pharma Ventures Ltd, 2004;
11.    Jimenez-Castellanos MR, Zia H, Rhodes CT, Mucoadhesives drug delivery systems, Drug Dev. Ind. Pharm. 1993; 19 : 143–194.
12.    Gohel MC, Sharma R, Soniwala MM. Development of taste masked film of Valdecoxib for oral use. Ind J Pharm Sci. 2007; 69: 318-320.
13.    Jayjock E, Schmitt R, Chein C. Determination of fast dissolve oral film dissolution rate via conductivity. Dow Chemical Company. 2005; 1-4.
14.    Joseph R. Robinson, Vincent H. Lee. Transdermal Therapeutic Systems. Chapter No: 12 in Control drug delivery. 2nd edition 1987;  (29) : 523-531.
15.    Carpel MC, Erasmo AM, Rowena SW, Elizebath PH, Randoll Z, Drug intelligence and clinical pharmacy. 1987; 642.
16.    Yie W. Chien. Transdermal drug delivery and delivery systems. Chapter-7 in Novel drug delivery systems, 2nd edition, Marcel Dekker Inc, Newyork. 302.
17.    Osborne and Hattzenbuler. The influence of skin surface lipids on topical formulations. In Topical drug delivery formulations. David W. Obsorne, Abntun H. Anamn, Marcel Dekker Inc, 1990; 70-71.

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