Author(s): Gurram Lakshmana murthy, Vasia Tamreen, Chandrika C., Shazia Iryn, Suchitra M, Balireddy N, Nagaraja Sreeharsha, Shaik Sadik

Email(s): murthympharm@gmail.com

DOI: 10.52711/0974-360X.2021.00487   

Address: Gurram Lakshmana murthy1, Vasia Tamreen1, Chandrika C.2, Shazia Iryn1, Suchitra M3, Balireddy N4, Nagaraja Sreeharsha5,6, Shaik Sadik7
1Department of Pharmaceutics, Oxbridge College of Pharmacy, Bengaluru-91, Karnataka, India.
2Department of Pharmacy Practice, Oxbridge college of Pharmacy, Bengaluru-91, Karnataka, India.
4Department of Pharmaceutical Chemistry, Bapuji college of Pharmacy, Davanagere, Karnataka, India.
4Department of Pharmaceutical chemistry, Oxbridge college of Pharmacy, Bengaluru-91, Karnataka, India.
5Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al Ahsa-31982, Saudi Arabia.
6Department of Pharmaceutics, Vidyasiri College of Pharmacy, Off Sarjapura Road, Bengaluru-560035, Karnataka, India.
7Department of Pharmacology, Oxbridge college of Pharmacy, Bengaluru-91, Karnataka, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
The main of the research work to develop sustained release floating matrix tablets of ATZ, which were designed to extend the gastric residence time and prolong the drug release after oral administration. Different grades of polymers such as EC and HPMC K100M were used in order to get the desired floating and sustained release profile over prolonged period of time. All the formulations extended the drug release up to 24 hours and more and the formulations were optimized for the desired release profiles. The release and floating property was depends on the polymer type and polymer proportion. The formulation prepared with Ethyl cellulose and HPMC K100M has more floating time than the formulation prepared with the Ethyl cellulose alone. The FTIR study shows that there is no drug-polymer interaction. This study gives the preliminary idea about the development of the floating drug delivery systems of Atazanavir without the use of gas generating agent.


Cite this article:
Gurram Lakshmana murthy, Vasia Tamreen, Chandrika C., Shazia Iryn, Suchitra M, Balireddy N, Nagaraja Sreeharsha, Shaik Sadik. Design and In vitro Evaluation of floating tablets Containing Atazanavir Sulphate. Research Journal of Pharmacy and Technology. 2021; 14(5):2763-0. doi: 10.52711/0974-360X.2021.00487

Cite(Electronic):
Gurram Lakshmana murthy, Vasia Tamreen, Chandrika C., Shazia Iryn, Suchitra M, Balireddy N, Nagaraja Sreeharsha, Shaik Sadik. Design and In vitro Evaluation of floating tablets Containing Atazanavir Sulphate. Research Journal of Pharmacy and Technology. 2021; 14(5):2763-0. doi: 10.52711/0974-360X.2021.00487   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-71


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