Author(s): Hiba Ali Hasan, Afrah Salman, Emilia Abdulmalek

Email(s): hibaalichemist@uomustansiriyah.edu.iq

DOI: 10.52711/0974-360X.2021.00423   

Address: Hiba Ali Hasan1*, Afrah Salman2, Emilia Abdulmalek3,4
1Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
4Integrated Chemical BioPhysics Research, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Pursuing our interest in bioactive heterocyclic compound, two benzoimidazoquinazoline derivatives were synthesised using both microwave-assisted and classical heating methods. Structures of the compounds were confirmed by standard spectroscopic methods and elemental analysis. The target scaffolds were incidentally found to emit blue light when exposed to ultraviolet light. Consequently, a photoluminescence characterization was carried out as a part of characterization protocol. The anticancer activities of the benzimidazoquinazoline compounds were investigated using both methylthiazol tetrazolium (MTT) and the high content screen (HCS) assays against liver hepatocellular cells. The results showed a significant reduction in the inhibitory concentration of the cancer cells by 1 and 2.6 fold when exposed to compounds (3a) and (3b), respectively. The high content screen (HCS) was conducted for compound (3b) and the results showed high toxicity towards the cancer cells.


Cite this article:
Hiba Ali Hasan, Afrah Salman, Emilia Abdulmalek. Anticancer Activity and High Content Screening of New 6-Substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline Derivatives. Research Journal of Pharmacy and Technology. 2021; 14(5):2397-5. doi: 10.52711/0974-360X.2021.00423

Cite(Electronic):
Hiba Ali Hasan, Afrah Salman, Emilia Abdulmalek. Anticancer Activity and High Content Screening of New 6-Substituted-5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazoline Derivatives. Research Journal of Pharmacy and Technology. 2021; 14(5):2397-5. doi: 10.52711/0974-360X.2021.00423   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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