Author(s): Anjana S, Beena P, Shahana S, Namitha Navas, Sam Cherian Mathew, Salikh Salim, Elessy Abraham

Email(s): Email ID Not Available

DOI: 10.52711/0974-360X.2021.00485   

Address: Anjana S1*, Dr. Beena P2, Shahana S1, Namitha Navas1, Sam Cherian Mathew1, Salikh Salim1, Dr. Elessy Abraham3
1M. Pharm Delegate, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
2Professor, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
3Principal, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Periodontal disease causes destruction of adjuvant structures of the teeth predominate in all groups, ethnicities, races and both genders. Systemic antibiotic therapy is employed in treating this diseased condition, but it has limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. These controlled intra-pocket devices also help in the maintenance of therapeutic drug concentration for the desired period of time. The goal of this research was to fabricate controlled release dental films, loaded with Tinidazole as an antimicrobial agent which consists of a common nonbiodegradable polymer and a co-polymer in different proportions for targeted delivery of drug. Nine formulations of Tinidazole dental films were prepared with ethyl cellulose as the main common non- biodegradable polymer and different co-polymers like PVPK30, HPMC K4M, Eudragit RL 100 in three ratios using solvent casting method. These films were evaluated for various parameters like thickness uniformity, content uniformity, swelling index, percentage moisture loss, in vitro drug release studies etc. Based on these parameters best film was selected as the one which is prepared with ethyl cellulose and eudragit RL100 (20%w/w of ethyl cellulose) i.e F5, since it can release the drug above MIC in each day of treatment and it is having sufficient drug content and other required film characteristics. The kinetic models of the formulation F5 was then found and it indicated that the formulation undergoes zero order release kinetics and model fits to Higuchi which is indicative of the diffusion mechanism of drug release. The mechanism of drug release was found to be Non-Fickian. From all of these studies it was concluded that Ethyl cellulose - Eudragit RL100 (20%w/w of EC) combination is the best carrier among the other polymers for the Tinidazole film for the treatment of periodontitis.


Cite this article:
Anjana S, Beena P, Shahana S, Namitha Navas, Sam Cherian Mathew, Salikh Salim, Elessy Abraham. Formulation and Evaluation of Intrapacket Dental Film of Antibacterial agent for Periodontitis. Research Journal of Pharmacy and Technology. 2021; 14(5):2750-6. doi: 10.52711/0974-360X.2021.00485

Cite(Electronic):
Anjana S, Beena P, Shahana S, Namitha Navas, Sam Cherian Mathew, Salikh Salim, Elessy Abraham. Formulation and Evaluation of Intrapacket Dental Film of Antibacterial agent for Periodontitis. Research Journal of Pharmacy and Technology. 2021; 14(5):2750-6. doi: 10.52711/0974-360X.2021.00485   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-69


REFERENCES:
1.    Sunil A, Venkatesh M, Udupa N. Controlled-drug delivery systems for periodontitis. The Pharm Review 2004, Jul-Aug; 61-82.
2.    Pandit JK, Targeted devices for periodontal disease. Ed by Jain NK. Controlled and novel drug delivery. New Delhi: CBS Publishers and distributors; 2004
3.    Vineetha VC, Maria M. Development and evaluation of dental films containing an antibacterial agent for the treatment of periodontitis. Int J Pharm Pharm Sci 2014; 7:52-9.
4.    Indian Pharmacopeia, 2010, Volume 3, Government of India, Ministry of Health and Family Welfare, The Indian Pharmacopeia Commission, Ghaziabad, 2010, pp 241-244.
5.    Sudeep K, Gnanaranjan, Preeti K. Formulation and evaluation of Erythromycin dental implants for periodontitis. Int. J. Drug Res. Tech. 2012; 2 (5):407-10.
6.    Reddy CSK, Khan A, Nagaraja C. A Review on the Determination of Melting Point Measurement System. Int J Adv Res Electric Electron Inst Eng. 2016; 5(2):975-979.
7.    Cartensen JT, Preformulation, In: Banker GS, Rodes CT, Modern Pharmaceutics, 3rd edition, Volume 72, New York: Marcel Dekker, 1996, pp213-238.
8.    Patel P, Ahir K, Patel V, Manani L, Patel C. Drug-excipient compatibility studies; first step for dosage form development. J Pharm Innov. 2015;4(5):14-20.
9.    C N Sreeja, K R Anoop. Design and In Vitro Evaluation of Controlled Release Satranidazole Subgingival films for Periodontitis Therapy. Int J Pharm Sci Rev Res. 2014; 24(1): 8-14.
10.    Seth A K, Agarwal G P, Saini T R, Evaluation of free films, Indian Drugs, 1985; 23: 45-47.
11.    Manubolu K, Chandana AV, Prakash P. Formulation and in vitro characterizations of amitriptyline buccal films. World J Pharm Pharm Sci. 2014; 3:1547-5.
12.    Minabe M. Application of a local drug delivery system to periodontal therapy. I. Development of collagen preparation with immobilized tetracycline. J Periodontol 1989; 60: 113-7.
13.    Chadha VS, Arora K, Manjunath BC, Kalra S. Local drug delivery in periodontics-current concepts and trends. Int J Adv Res Oral Sci 2012; 1:1-9
14.    Prashant M, Satturwar S, Fulzele V, Avinash K. Dorle evaluation of polymerized rosin for the formulation and development transdermal drug delivery systems. AAPS Pharmscitech. 2005; 6:48-53.
15.    Prabushankar GL, Gopalkrishna B, Manjunatha KM, Girisha CH. Formulation and evaluation of levofloxacin dental films for periodontitis. Int J Pharm Pharm Sci .2010; 2(1):162-08.
16.    Singh N, Malviya R, Bansal M, Kumar S P. Formulation and Evaluation of Different Polymer based Periodontal Film of Ofloxacin. Der Pharmacia Lettre, 2010; 2(3): 297-303.Characterizations of Amitriptyline buccal films. World J Pharm Pharm Sci.2014; 3:1547-5

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