Author(s): Fouzia Tehseen, Syed Safiullah Ghori, Mohammed Dawood, Shafia Tazeen, Kulsum Sara, Abdul Samad

Email(s): fouziatehseen@gmail.com

DOI: 10.52711/0974-360X.2021.00483   

Address: Fouzia Tehseen1*, Syed Safiullah Ghori2, Mohammed Dawood1, Shafia Tazeen1, Kulsum Sara1, Abdul Samad3
1Department of Pharmaceutical Chemistry, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India, 500008.
2Department of Pharmacology, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India, 500008.
3Research Scholar, Government Nizamia Tibbi College, Charminar, Hyderabad, Telangana, India, 500008.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Ayurveda is the ancient Indian system of medicine which includes the usage of natural and mechano procedures to eliminate the root cause of the disease. Ayurvedic system of medicine is economical, easily available and free of side effects which make it beneficial to human beings. Among various diseases, a large population is infected with helminthiasis which can be treated by using medicinal plants. In the present study we developed a novel polyherbal formulation (PHF) containing a mixture of powdered Artemesia absinthium (shoot), Butea Monosperma (leaves), Ipomea headeraceae (seeds), Hyocyamus niger (seeds). Phytochemical screening of the extract indicated the presence of carbohydrates, amino acids, tannins, sterols and alkaloids the polyherbal formulation was studied for its anthelmintic activity using Indian earthworm (Pheritima posthuma) as the test model. Albendazole was taken as the standard reference drug. The petroleum ether and aqueous extracts with the petroleum ether and methanolic extract. of the PHF of different concentrations (25µg/ml, 50µg/ml, 100µg/ml) were prepared and used to determine the paralysis time and death time of the worms. The petroleum ether and methanolic extract of the PHF has shown significant activity due to presence of various phytoconstituents like tannins, flavonoids and alkaloids. In the course of our investigation, we found that the 100µg/ml methanolic extract has better anthelmintic activity when compared to the other concentrations checked.


Cite this article:
Fouzia Tehseen, Syed Safiullah Ghori, Mohammed Dawood, Shafia Tazeen, Kulsum Sara, Abdul Samad. Phytochemical Screening and Invitro Anthelmintic Activity of a Novel Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2021; 14(5):2742-4. doi: 10.52711/0974-360X.2021.00483

Cite(Electronic):
Fouzia Tehseen, Syed Safiullah Ghori, Mohammed Dawood, Shafia Tazeen, Kulsum Sara, Abdul Samad. Phytochemical Screening and Invitro Anthelmintic Activity of a Novel Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2021; 14(5):2742-4. doi: 10.52711/0974-360X.2021.00483   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-67


REFERENCES:
1.    V. Subbose et al. Basic principles of Pharmaceutical science in Ayurveda. Bulletin of the Indian Institute of History of medicine. 2005; 35(2): 83-92.
2.    M.M. Pandey et al. Indian Traditional Ayurvedic System of Medicine and Nutritional supplementation. Evidence based complementary and alternative Medicine. 2013; 13.
3.    Mukherjee PK et al. GMP for Botanicals and Quality Issues on Phytomedicines. Bussiness Horizons. 2003.
4.    Chaudhri RD. Herbal Drugs Industry. The Easter Publishers. 1996; 1.
5.    Patwardhan B et al. Ayurveda and future drug development. International Journal of Alternative and Complimentary Medicine. 1992; 9.
6.    Singh Karam et al. Int. J. Res. Ayurveda Pharm. 2013; 4(4).
7.    The Merck Index. 12th  Edition. 1996; 1119.
8.    Maddi Ramaiya et al. Investigation of invitro anthelmintic activity of Diospros malabarica. IJPPR, 2016; 9(8): 1135-37.
9.    Dwivedi S et al. Relevance of medicinal herbs used in traditional system of medicine. Farmavita. Net. 2007.
10.    Shabi Ruskin. R, S. Ajina. Qualitative Phytochemical screening and invitro Anthelmintic Activity of Adhatoda vasica. Research J. Pharm and Tech. 2017; 10(2): 10: 414-420.
11.    C. K. Kokate, S. B Gokhale. Practical Pharmacognosy. 2009.
12.    Ajaiyeoba EO, Onocha PA and Olarenwaju OT. In-vitro anthelmintic properties of Buchholzia coiaceae and Gynandropsis gynandra extract. Pharmaceutical Biology. 2001; 39: 217–220.
13.    Umakrithika et al. Investigation of invitro anthelmintic activity of Lindernia madayiparense. Research J. Pharm and Tech. 2018; 11(1): 183-186.
14.    Dhenge R. et al. Anthelmintic Activity of Methanolic Extract of Steriospermum xylocarpum. Research J. Pharm. Ad Tech. 2001: 3 (4), 1064-1065.
15.    Tripathi KD. Essentials of Medical Pharmacology. Jaypee. 2013.

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