Author(s): Prabhat Singh, Bhupesh Sharma

Email(s): sharmaslab2@gmail.com , bsharma5@amity.edu , drbhupeshresearch@gmail.com

DOI: 10.52711/0974-360X.2021.00479   

Address: Prabhat Singh1, Bhupesh Sharma2,3*
1Ph.D Student, Neuropharmacology Lab., Department of Pharmacology, KSCP, Subharti University, Meerut, Uttar Pradesh, India.
2Professor, Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Sector-125, Noida - 201313, Uttar Pradesh, India.
3Chief Consultant, CNS Pharmacology, Conscience Research, Pocket F- 233, B (Near Sai Vatika), Dilshad Garden, Delhi - 110095 India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Cerebral ischemia and ischemia-reperfusion is an essential contributor to acute cerebral stroke. Ischemic preconditioning (IPC) has been proven to provide neuroprotection in ischemia-reperfusion injury in rats, but their mechanism behind neuroprotection in cerebral stroke are still unclear. Central histaminergic pathway has crucial role in the pathogenesis of cerebral stroke, but their neuroprotective role in IPC is still unidentified. This research explores the role of histamine-1 receptor in IPC induced neuroprotection against ischemia-reperfusion induced cerebral injury. Rat were subjected to 17 min of global cerebral ischemia (GCI) by occluding both carotid arteries followed by reperfusion for 24 h, to produce ischemia-reperfusion induced cerebral injury. TTC staining was used to measure cerebral infarct size. Morris water maze test was used to assess memory. Inclined beam-walk, hanging wire, lateral push and rota-rod tests were used to assess degree of motor incoordination. Brain acetylcholinesterase activity, nitrite/nitrate, glutathione, TBARS and MPO levels were also examined. GCI has produced a significant increase in cerebral infarction, brain nitrite/nitrate, MPO, TBARS and AChE activity along with a reduction in glutathione content. Impairment of memory and motor coordination were also noted in GCI induced rat. IPC was employed that consist of 3 preceding episodes of ischemia (1 min) and reperfusion (1 min) both immediately before GCI significantly decreased cerebral infarction, motor incoordination, memory impairment and biochemical impairment. Pretreatment with L-histidine mimicked the neuroprotective effects of IPC. L-histidine induced neuroprotection were significantly abolished by chlorpheniramine, a H1 receptor antagonist. We conclude that neuroprotective effects of IPC, probably occurs through the central histaminergic pathway, and histamine-1 receptor could be a new target behind the neuroprotective mechanism of IPC.


Cite this article:
Prabhat Singh, Bhupesh Sharma. Pharmacological connection of Histamine-1 (H1) Receptor Mediated Neuroprotective mechanism of Ischemic preconditioning in rat.Research Journal of Pharmacy and Technology. 2021; 14(5):2717-2. doi: 10.52711/0974-360X.2021.00479

Cite(Electronic):
Prabhat Singh, Bhupesh Sharma. Pharmacological connection of Histamine-1 (H1) Receptor Mediated Neuroprotective mechanism of Ischemic preconditioning in rat.Research Journal of Pharmacy and Technology. 2021; 14(5):2717-2. doi: 10.52711/0974-360X.2021.00479   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-63


REFERENCES:
1.    Gulati P, Singh N. Pharmacological evidence for connection of nitric oxide-mediated pathways in neuroprotective mechanism of ischemic postconditioning in mice. J Pharm Bioallied Sci. 2014; 6(4): 233-40.
2.    Rehni AK, Singh TG. Involvement of CCR-2 chemokine receptor activation in ischemic preconditioning and postconditioning of brain in mice. Cytokine. 2012; 60(1): 83-9.
3.    Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986; 74(5): 1124-36.
4.    Kitagawa K, et al. Ischemic tolerance' phenomenon detected in various brain regions. Brain Res. 1991; 561(2): 203-11.
5.    Vecino R, et al. The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia. Sci Rep. 2018; 8(1): 1610.
6.    Stetler RA, et al. Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance. Prog Neurobiol. 2014; 114: 58-83.
7.    Liao Z, et al. Remote ischemic conditioning improves cognition in patients with subcortical ischemic vascular dementia. BMC Neurol. 2019; 19(1): 206.
8.    Wang H, et al. Modulating effects of preconditioning exercise in the expression of ET-1 and BNP via HIF-1α in ischemically injured brain. Metab Brain Dis. 2019; 34(5): 1299-1311.
9.    Fan YY, et al. Activation of the central histaminergic system is involved in hypoxia-induced stroke tolerance in adult mice. J Cereb Blood Flow Metab. 201; 31(1): 305-14.
10.    Karpati A, et al. Histamine H1 receptor on astrocytes and neurons controls distinct aspects of mouse behaviour. Sci Rep. 2019; 9(1): 16451.
11.    Hu WW, Chen Z. Role of histamine and its receptors in cerebral ischemia. ACS Chem Neurosci. 2012; 3(4): 238-47.
12.    Rakhunde PB, Saher S, Ali SA. Neuroprotective effect of Feronia limonia on ischemia reperfusion induced brain injury in rats. Indian J Pharmacol. 2014; 46(6): 617-21.
13.    Singh P, Sharma B. Selective Serotonin-norepinephrine Re-uptake Inhibition Limits Renovas-cular-hypertension Induced Cognitive Impairment, Endothelial Dysfunction, and Oxidative Stress Injury. Curr Neurovasc Res. 2016; 13(2): 135-46.
14.    Naderi Y, et al. Neuroprotective effects of pretreatment with minocycline on memory impairment following cerebral ischemia in rats. Behav Pharmacol. 2017; 28: 214-222.
15.    Aboutaleb N, et al. Protection of Hippocampal CA1 Neurons Against Ischemia/Reperfusion Injury by Exercise Preconditioning via Modulation of Bax/Bcl-2 Ratio and Prevention of Caspase-3 Activation. Basic Clin Neurosci. 2016; 7(1): 21-9.
16.    Kumagae Y, Matsui Y. Output, tissue levels, and synthesis of acetylcholine during and after transient forebrain ischemia in the rat. J Neurochem. 1991; 56(4): 1169-73.
17.    Lu Y, et al. The protective effects of propofol against CoCl2-induced HT22 cell hypoxia injury via PP2A/CAMKIIα/nNOS pathway. BMC Anesthesiol. 2017; 17(1): 32.
18.    Irisawa Y, et al. Alleviation of ischemia-induced brain edema by activation of the central histaminergic system in rats. J Pharmacol Sci. 2008; 108(1): 112-23.
19.    Schetinger MR, et al. Pre-conditioning to global cerebral ischemia changes hippocampal acetylcholinesterase in the rat. Biochem Mol Biol Int. 1999; 47(3): 473-8.
20.    Adachi N, et al. A comparison of protective effects between L-histidine and hypothermia against ischemia-induced neuronal damage in gerbil hippocampus. Eur J Pharmacol. 2006; 546(1-3): 69-73.
21.    Díaz-Trelles R, et al. Antihistamine terfenadine potentiates NMDA receptor-mediated calcium influx, oxygen radical formation, and neuronal death. Brain Res. 2000; 880(1-2): 17-27.
22.    Saad MA, et al. Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats. Chem Biol Interact. 2015; 232: 21-9.
23.    Zhang QG, et al. Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk. Neurosci Res. 2009; 63(3): 205-12.
24.    Hu YY, et al. GLT-1 Upregulation as a Potential Therapeutic Target for Ischemic Brain Injury. Curr Pharm Des. 2017; 23(33): 5045-5055.
25.    Rothstein JD, et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 1996; 16(3): 675-86.
26.    Wang X, et al. Pre-ischemic treadmill training alleviates brain damage via GLT-1-mediated signal pathway after ischemic stroke in rats. Neuroscience. 2014; 274: 393-402.
27.    Fang Q, et al. Histamine up regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury. Neuropharmacology. 2014; 77: 156-66.
28.    Díaz-Trelles R, et al. Antihistamine terfenadine potentiates NMDA receptor-mediated calcium influx, oxygen radical formation, and neuronal death. Brain Res. 2000; 880(1-2): 17-27.

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