Author(s): Job Herman Berkhout, Aswatha Ram H. N., Mahalaxmi Rathnanand

Email(s): aswatharam@gmail.com

DOI: 10.52711/0974-360X.2021.00478   

Address: Job Herman Berkhout1, Aswatha Ram H. N.2*, Mahalaxmi Rathnanand3
1Faculty of Science, Radboud University, Nijmegen, the Netherlands.
2Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, India.
3Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences,
Manipal Academy of Higher Education, Manipal - 576104, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol.


Cite this article:
Job Herman Berkhout, Aswatha Ram H. N., Mahalaxmi Rathnanand. pKa Determination of Carvedilol by Spectrophotometry. Research Journal of Pharmacy and Technology. 2021; 14(5):2714-6. doi: 10.52711/0974-360X.2021.00478

Cite(Electronic):
Job Herman Berkhout, Aswatha Ram H. N., Mahalaxmi Rathnanand. pKa Determination of Carvedilol by Spectrophotometry. Research Journal of Pharmacy and Technology. 2021; 14(5):2714-6. doi: 10.52711/0974-360X.2021.00478   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-62


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