Author(s): Diana Ali Alkhalil, Moofeed Yasein

Email(s): dianaalialkhalil@gmail.com , moufidy@tishreen.edu.sy

DOI: 10.52711/0974-360X.2021.00421   

Address: ~2
1Master Student in Analytical and Food Chemistry Department, Faculty of Pharmacy, Tishreen University, Lattakia, Syria.
2Prof. Dr. in Analytical and Food Chemistry Department, Faculty of Pharmacy, Tishreen University, Lattakia, Syria.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. It was first approved by the US Food and Drug Administration (FDA) in 1981. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. these metabolites have some health risks specially on PKU (Phenyl Ketone Urea) patients who can’t metabolize the amino acid phenyl alanine. This study aims to investigate the health effects of aspartame on Balb-c mice. 16 Balb-c mice were given physiological solution by oral gavage(control) and the study groups were given the recommended ADI (Acceptable Daily Intake) for mice (ADI = 250mg/kg/body weight) of Aspartame diluted in water for 15days, 30days. Glucose blood level, lipid profile, marker enzymes (ALT.AST.ALP, ?GT) and uric acid were determined at the end of the experiment. The results of this study show that oral administration of aspartame (250mg/kg body weight) was correlated to a significant increase in the lipid profile, fasting blood glucose and some marker enzymes and this increase is time related.


Cite this article:
Diana Ali Alkhalil, Moofeed Yasein. Investigation of Aspartame effects on some blood parameters after oral administration in Balb-c mice. Research Journal of Pharmacy and Technology. 2021; 14(5):2387-0. doi: 10.52711/0974-360X.2021.00421

Cite(Electronic):
Diana Ali Alkhalil, Moofeed Yasein. Investigation of Aspartame effects on some blood parameters after oral administration in Balb-c mice. Research Journal of Pharmacy and Technology. 2021; 14(5):2387-0. doi: 10.52711/0974-360X.2021.00421   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-5


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