Most of the synthetic drugs used at present as analgesic and anti-inflammatory agents cause many side effects and toxic effects. Many medicines of plant origin with analgesic and anti-inflammatory activity have been used since long time without adverse effects. The purpose of the study was to explore the anti-pyretic and anti-oxidant activity of fruits of Garcinia pedunculata. The fruit of G. pedunculata was collected from Shillong, Meghalaya and extraction is done by using methanol as a solvent. The methanol extract shows the presence of carbohydrate, glycoside, alkaloids, phenol and flavonoids. Acute anti-pyretic activity for the extract was investigated in pyrexia rat. Temperature level was determined after 1hours, 4 hours, 8 hours and 12 hours after giving the extract dose of 100mg/kg and 200mg/kg body weight, and it was found to produce a significant reduce in fever. DPPH radical scavenging activity (In-vitro anti-oxidant activity of G. pedunculata) of methanolic extract shows 38.31 as IC50 (µg/ml) whereas Ascorbic acid as standard in the same concentration shows 34.81 IC50 (µg/ml). The obtained result justified the traditional use of G. pedunculata as anti-pyretic and antioxidant purpose.
Cite this article:
Mrinmoy Basak, Moksood Ahmed Laskar, Priyanka Goswami. Evaluation of Anti-oxidant and Anti-pyretic activity of fruits of Garcinia pedunculata. Research Journal of Pharmacy and Technology. 2021; 14(5):2635-8. doi: 10.52711/0974-360X.2021.00464
Mrinmoy Basak, Moksood Ahmed Laskar, Priyanka Goswami. Evaluation of Anti-oxidant and Anti-pyretic activity of fruits of Garcinia pedunculata. Research Journal of Pharmacy and Technology. 2021; 14(5):2635-8. doi: 10.52711/0974-360X.2021.00464 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-48
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