Author(s): Mrinmoy Basak, Moksood Ahmed Laskar, Priyanka Goswami

Email(s): mrinmoybsk@gmail.com

DOI: 10.52711/0974-360X.2021.00464   

Address: Mrinmoy Basak, Moksood Ahmed Laskar, Priyanka Goswami
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati - 26. Assam, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Most of the synthetic drugs used at present as analgesic and anti-inflammatory agents cause many side effects and toxic effects. Many medicines of plant origin with analgesic and anti-inflammatory activity have been used since long time without adverse effects. The purpose of the study was to explore the anti-pyretic and anti-oxidant activity of fruits of Garcinia pedunculata. The fruit of G. pedunculata was collected from Shillong, Meghalaya and extraction is done by using methanol as a solvent. The methanol extract shows the presence of carbohydrate, glycoside, alkaloids, phenol and flavonoids. Acute anti-pyretic activity for the extract was investigated in pyrexia rat. Temperature level was determined after 1hours, 4 hours, 8 hours and 12 hours after giving the extract dose of 100mg/kg and 200mg/kg body weight, and it was found to produce a significant reduce in fever. DPPH radical scavenging activity (In-vitro anti-oxidant activity of G. pedunculata) of methanolic extract shows 38.31 as IC50 (µg/ml) whereas Ascorbic acid as standard in the same concentration shows 34.81 IC50 (µg/ml). The obtained result justified the traditional use of G. pedunculata as anti-pyretic and antioxidant purpose.


Cite this article:
Mrinmoy Basak, Moksood Ahmed Laskar, Priyanka Goswami. Evaluation of Anti-oxidant and Anti-pyretic activity of fruits of Garcinia pedunculata. Research Journal of Pharmacy and Technology. 2021; 14(5):2635-8. doi: 10.52711/0974-360X.2021.00464

Cite(Electronic):
Mrinmoy Basak, Moksood Ahmed Laskar, Priyanka Goswami. Evaluation of Anti-oxidant and Anti-pyretic activity of fruits of Garcinia pedunculata. Research Journal of Pharmacy and Technology. 2021; 14(5):2635-8. doi: 10.52711/0974-360X.2021.00464   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-48


REFERENCES:
1.    Akapa T C, Kehinde A O, Antipyretic Activity of Abutilon mauritianum (Jacq.) roots in Wistar rats, International Journal of Pharmaceutical Sciences and Research, 2014,0975-9492, 5(02).
2.    M.J. Kluger. Fever, Role of pyrogens and cryogens. Physiol Rev., 1991, 71: 93- 127.
3.    Paarakh P M, Nigella sativa Linn. – A comprehensive review. Indian Journal of Natural Products and Resources. 2010, 1, 4: 409-429.
4.    Huang D J, Chen H J, Lin C D, Lin Y H, Antioxidant and antiproliferative activities of water spinach (Ipomea aquatica Frosk.) constituents. Botanical Bulletin Academia Sin. 2005; 406: 99-106.
5.    Rice-Evans C A, Miller N J, Bolwell P G, The relative antioxidant activities of plant-derived polyphenolic flavonoids,” Free Radical Research, 1995, 22(4);375–383.
6.    Gerber M, Boutron-Ruault M C, Hercberg C, Riboli E, Food and cancer: state of the art about the protective effect of fruits and vegetables, Bulletindu Cancer, 2002 89(3); 293-312.
7.    Sharma B D, Sanjappa M, Flora of India, Botanical Survey of India, Calcutta, 1993, 3, 98-131.
8.    Kar A, Borkakoti S, Borthakur S K, Extended distribution of the genus Garcinia L. in sonitpur district, Assam, India, 2008, 2(2), 165-170.
9.    Iinuma M, Tosha H, Tanaka T et al. antibacterial activity of some Garcinia benzophenone derivatives against methicillin-resistant Staphylococcus aureus biological and pharmaceutical bulletin, 1996, 19, 311-314.
10.    Sen S, Dey B, Chakraborty R, Total phenolic, total flvonoid content, and antioxidant activity of leaves of Megna spinosa Roxb, an Indian medicinal plant. Chinese Journal of Natural Medicine, 2013, 11(2); 0149-0175.
11.    Jamuna S, Paulsamy S and Karthika K, Screening of in vitro antioxidant activity of methanolic leaf and root extracts of Hypochaeris radicata L. (Asteraceae); Journal of Applied Pharmaceutical Science 02 (07); 2012: 149-154.
12.    S.S. Adams, P. Hebborn, J.S. Nicholson. Some aspects of the pharmacology of ibufenac, a non-steroidal anti-inflammatory agent. J. Pharm. Pharmac., 1968, 20: 305-312.
13.    G.H. Vogel. Drug Discovery and Evaluation Pharmacological Assays. Springer, New York.2002, 2nd edition, 716.
14.    Gangwar M, Gautam M K, Sharma A K, Antioxidant Capacity and Radical Scavenging Effect of Polyphenol Rich Mallotus philippenensis Fruit Extract on Human Erythrocytes: An In Vitro Study; Hindawi Publishing Corporation Scientific World Journal Volume 2014, 12 pages.
15.    Mutalik S, Paridhavi K, Udupa N, Antipyretic and analgesic effect of Solanum melongena, Indian J Pharmacol 2003;35:312-5. Jamuna S, Paulsamy S and Karthika K, Screening of in vitro antioxidant activity of methanolic leaf and root extracts of Hypochaeris radicata L. (Asteraceae); Journal of Applied Pharmaceutical Science 02 (07); 2012: 149-154.
16.    Rekka E, Kourounakis P N Effect of hydroxyethyl rutenosides and related compounds on lipid peroxidation and free radical scavenging activity-some structural aspects. J. Pharm Pharmacol. 1991; 43: 486-491.
17.    Goswami P, Pharmacognostical, phytochemical and anthelmentic activity of Polygonum muricatum, Journal of Applied Pharmaceutical Science, 2018, 6(3), 07 – 12.

Recomonded Articles:

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): S. R Suseem, Dhanish Joseph

DOI: 10.5958/0974-360X.2019.00067.2         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Author(s): Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Fathima Mariyam Niyas

DOI: 10.5958/0974-360X.2015.00182.1         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): Gopinath G, Thirumal M, P. R. Kumar

DOI: 10.5958/0974-360X.2020.00362.5         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Bharti Ahirwar, Dheeraj Ahirwar, Alpana Ram

DOI:         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): A. Rajendra Kumar, N. J. Muthukumar, A. Faridha

DOI: 10.5958/0974-360X.2019.00081.7         Access: Open Access Read More

Author(s): J.S. Vaghela, S.S. Sisodia

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags