Author(s): K. Gouri Sankar, B. S. Venkateswarlu

Email(s): kgspharma18@gmail.com

DOI: 10.52711/0974-360X.2021.00463   

Address: K. Gouri Sankar1,2*, B. S. Venkateswarlu2
1Department of Pharmacognosy, MAM College of Pharmacy, Kesanupalli, Narasaraopet -522601 A.P. India.
2Department of Pharmaceutics, Vinayaka Mission College of Pharmacy,
Salem-636008 Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Now a days, oxidative stress is one of the major disease around the world. The excess production of oxidants in the body are key source for development of different chronic diseases and are leading to damage the multiple organs' function, finally to cellular mortality. The natural remedy is the most important medicine to control the overproduction of oxidants and to obtain more antioxidants. Natural product have been using to treat diseases and as food supplements as nutrients. In this point of view, the current study was carried to evaluate the antioxidant activity of Spilanthes acmella root parts. The free radical scavenging activity was studied against 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide and hydroxyl free radicals using standard methods. The Spilanthes acmella root part extracts showed concentration dependent antioxidant activity on tested free radicals. The extracts showed modest effect on free radicals compared to the standard drug ascorbic acid and hydro-alcoholic extract possesses more activity than other two extracts. The end results of current study clearly state that Spilanthes acmella root possess free radical scavenging activity and also confirms its' traditional value in traditional medicine. The further research is worthful on isolation of different bioactive molecules and different biological activities evaluation on Spilanthes acmella.


Cite this article:
K. Gouri Sankar, B. S. Venkateswarlu. Free radicals scavenging aptitude of Spilanthes acmella. Research Journal of Pharmacy and Technology. 2021; 14(5):2631-4. doi: 10.52711/0974-360X.2021.00463

Cite(Electronic):
K. Gouri Sankar, B. S. Venkateswarlu. Free radicals scavenging aptitude of Spilanthes acmella. Research Journal of Pharmacy and Technology. 2021; 14(5):2631-4. doi: 10.52711/0974-360X.2021.00463   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-47


REFERENCES:
1.    Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative Stress and Antioxidant Defense. WAO J. 2012; 5: 9-19.
2.    Liu Z, Ren Z, Zhang J, Chuang CC, Kandaswamy E, Zhou T et al, Role of ROS and nutritional antioxidants in human diseases. Front Physiol. 2018; 9: 477.
3.    Dröge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002; 82: 47-95.
4.    Salim S. Oxidative stress: A potential link between emotional wellbeing and immune response. Curr Opin Pharmacol. 2016; 29: 70-6.
5.    Pereira B, Rosa LF, Safi DA, Bechara EJ, Curi R. Superoxide dismutase, catalase and glutathione peroxidase activities in the lymphoid organs of diabetic rats. J Endocrinol. 1994; 142: 161-5.
6.    Griess B, Tom E, Domann F, Teoh-Fitzgerald M. Extracellular superoxide dismutase and its role in cancer. Free Radic Biol Med. 2017; 112; 464-79.
7.    Sofowora A, Ogunbodede E, Onayade A. The role and place of medicinal plants in the strategies for disease prevention. Afr J Tradit Complement Altern Med. 2013; 10(5): 210-29.
8.    Mallikarjuna Rao T, Rajananda Swamy T, Ganga Rao B. Glucose Lowering Effect of Zornia gibbosa extracts in Diabetic Rats. Turkish Journal of Pharmaceutical Sciences. 2018; 15(3): 339-46.
9.    Ventola CL. The antibiotic resistance crisis: Part 1: Causes and Threats. P T. 2015; 40(4): 277-83.
10.    Sharma GK. Studies on Phytochemical Constituents of Medicinal Plants. AJPPS. 2014; 1(4): 61-74.
11.    Kaido TL, Veale DJH, Havlik I, Rama DBK. Current and Future status of Herbal medicines. J Ethnopharmacol. 1997; 55: 185-191.
12.    Mallikarjuna Rao T, Ganga Rao B, Venkateswara Rao Y. Antioxidant activity of Spilanthes acmella extracts. International Journal of Phytophamacology. 2012; 3(2): 216-220.
13.    K. Gouri Sankar and B. S. Venkateswarlu. Evaluation of In-vitro antibacterial activity of Spilanthes acmella. Int Res J Pharm. 2019; 10(7): 91-93.
14.    Mc Cord JM, Fridovich I. Superoxide dismutase: An enzymic function for erythrocuprein (hemocuprien). Journal of Biological Chemistry. 1969; 244: 6049-55.
15.    Elizabeth K and Rao MNA. Oxygen radical scavenging activity of Curcumin. International Journal of Pharmaceutics. 1990; 58: 237-40.
16.    Braca A, Fico G, Morelli I, De Simone F, Tome F, De Tommasi N. Antioxidant and free radical scavenging activity of flavonol glycosides from different Aconitum species. J Ethnopharmacol. 2003; 86: 63-7.
17.    Anita Murali, Purnima Ashok, Madhavan V. In vitro antioxidant activity and HPTLC Studies on the roots and rhizomes of Smilax zeylanica l. (Smilacaceae). International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(1): 192-5.
18.    Dröge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002; 82: 47-95.
19.    Rasheed N, Ahmad A, Al-Sheeha M, Alghasham A, Palit G. Neuroprotective and anti-stress effect of A68930 in acute and chronic unpredictable stress model in rats. Neurosci Lett. 2011; 504(2): 151-155.
20.    Schiavone S, Jaquet V, Trabace L, Krause KH. Severe life stress and oxidative stress in the brain: from animal models to human pathology. Antioxid Redox Signal. 2013; 18(12): 1475-90.
21.    Meghri Katerji, Maria Filippova, and Penelope Duerksen-Hughes. Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field. Oxidative Medicine and Cellular Longevity. 2019: 1279250.
22.    Pizzino G, Irrera N, Cucinotta M, et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017; 8416763.
23.    Andy Wai Kan Yeung, Bharat Bhushan Aggarwal , Davide Barreca, Maurizio Battino, Tarun Belwal et al., Dietary natural products and their potential to influence health and disease including animal model studies. Animal Science Papers and Reports. 2018; 36(4): 345-358.
24.    Zhenquan Jia, Pon Velayutham Anandh Babu, Wei Chen, and Xiaolun Sun, Natural Products Targeting on Oxidative Stress and Inflammation: Mechanisms, Therapies, and Safety Assessment. Oxidative Medicine and Cellular Longevity. 2018: 6576093.
25.    Che CT, Zhang H. Plant Natural Products for Human Health. Int J Mol Sci. 2019; 20(4): 830.
26.    World Health Organization . WHO Traditional Medicine Strategy: 2014–2023. WHO Press; Geneva, Switzerland: 2013.
27.    Hsia C, Wu M, Velusamy M, Hsia C, Chou D, Tsai C, Hsu C, Jayakumar T, Chung C, Sheu J. Novel Therapeutic Agent against Platelet Activation In Vitro and Arterial Thrombosis In Vivo by Morin Hydrate. Int J Mol Sci. 2018; 19: 2386.
28.    Thomford N, Senthebane D, Rowe A, Munro D, Seele P, Maroyi A, Dzobo K. Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery. Int J Mol Sci. 2018; 19: 1578.
29.    Krause KH. Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp Gerontol. 2007; 42(4): 256-62.

Recomonded Articles:

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Sandeep DS, Narayana Charyulu R, Prashant Nayak, Aliss Maharjan, Indira Ghalan

DOI: 10.5958/0974-360X.2016.00163.3         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Bharti Ahirwar, Dheeraj Ahirwar, Alpana Ram

DOI:         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Josephin Nerling Rashida G., T. Venkatarathnakumar, R. Gowri, Ajithadhas Aruna

DOI: Not Available         Access: Open Access Read More

Author(s): Neha Rajput, Dinesh Sachan, Shikha Gangwar, Dipti Sachan

DOI: Not Available         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): R. Manikandan, A. Vijaya Anand

DOI: 10.5958/0974-360X.2015.00056.6         Access: Open Access Read More

Author(s): R. Suresh, D. Benitojohnson, C. Maheswari, R. Venkatnarayanan, R.Manavalan

DOI: 10.5958/0974-360X.2017.00128.7         Access: Open Access Read More

Author(s): AK Jain, Naveen Sharma, Amit Upadhyay, Ashish Dixit

DOI: Not Available         Access: Open Access Read More

Author(s): I. V. Rakovskaya, I. P. Smirnova, S. P. Syatkin, G. I. Myandina, S. M. Chibisov, M. L. Blagonravov, A. S. Skorik

DOI: 10.5958/0974-360X.2017.00141.X         Access: Open Access Read More

Author(s): A. Khuntia, S.K. Mohanty

DOI: Not Available         Access: Open Access Read More

Author(s): Suralkar Anupama A., Jadhav Asha S., Vaidya Gayatri S., Sharma Ashish, Meghraj Chaudary, Vivek Bhora

DOI: Not Available         Access: Open Access Read More

Author(s): Shailju G. Gurunani, Manjusha P. Yeole, Yogesh N. Gholse, Chaple D.R

DOI: 10.5958/0974-360X.2015.00115.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags