Suresh Kolli, K. Vijayasri, P.N. Murthy
Suresh Kolli1*, K. Vijayasri2, P.N. Murthy1
1Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, India.
2Department of Pharmaceutics, Malla Reddy College of Pharmacy, Secunderabad, India.
Volume - 14,
Issue - 5,
Year - 2021
The present research was aimed to formulate and evaluate Lansoprazole delayed release multiple unit pellets in capsules. Lansoprazole degrades in the acidic environment of the stomach. It is also unstable under conditions of high temperature and high humidity which leads to therapeutic inefficiency. Hence it is important to bypass the acidic pH of the stomach. Protection of drug from acidic environment is done by coating the drug with enteric polymer. In the present study, successive layers of drug layer, barrier layer and enteric layer was coated on the inert sugar spheres by using solution/suspension layering technique in Fluidized bed processor (FBP). The prepared drug layered and barrier layered pellets were evaluated for % yield. The prepared lubricated pellets were evaluated for flow properties i.e., bulk density, tapped density, compressibility index and hausner’s ratio. Lubricated pellets filled into size ‘1’ capsules and evaluated for drug content, drug content resisted in acid, invitro drug release studies and compared with the marketed product. The dissimilarity and similarity factors for the optimized and marketed formulations were found to be 84.29. Accelerated Stability Testing (AST) was performed as per the ICH guidelines at 40±5°C/75±5% RH for 6 months and found satisfactory.
Cite this article:
Suresh Kolli, K. Vijayasri, P.N. Murthy. Formulation and invitro evaluation of delayed release multiple unit pellets of Lansoprazole in capsules. Research Journal of Pharmacy and Technology. 2021; 14(5):2625-0. doi: 10.52711/0974-360X.2021.00462
Suresh Kolli, K. Vijayasri, P.N. Murthy. Formulation and invitro evaluation of delayed release multiple unit pellets of Lansoprazole in capsules. Research Journal of Pharmacy and Technology. 2021; 14(5):2625-0. doi: 10.52711/0974-360X.2021.00462 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-46
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