Author(s): Mamta Tiwari, Pushpraj S Gupta, Nisha Sharma

Email(s): mamta1712@gmail.com

DOI: 10.52711/0974-360X.2021.00461   

Address: Mamta Tiwari1*, Pushpraj S Gupta2, Nisha Sharma3
1Research Scholar, Christian School of Pharmacy, SHUATS, Prayagraj (U.P.)
2Associate Professor, Christian School of Pharmacy, SHUATS, Prayagraj (U.P.)
3Associate Professor, University Institute of Pharmacy, C.S.J.M.U, Kanpur.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Cissus quadrangularis L. is a member of succulent climber of family Vitaceae and it is also called as bone setter because of its bone healing property. The present study focused to assess the in vitro antioxidant and in vivo anti-inflammatory activity of the plant stem extracts in different solvents namely petroleum ether, chloroform, ethyl acetate and methanol. Among all these extracts; ethyl extract showed highest phenolic and flavonoid content (19.35±0.29mg GA/g, 8.68±0.06 RE/g dry wt. respectively). In DPPH free radical scavenging assay all mentioned extracts exhibited free radical scavenging activity but the highest free radical scavenging activity was showed by ethyl acetate extract in increasing dose dependent manner. On the basis of highest phenolic, flavonoid content and free radical scavenging activity ethyl acetate extract was selected for anti- inflammatory activity. The anti-inflammatory activity of Cissus quadrangularis Lin. was investigated in carageenan induced inflammation in Wistar albino rats. Two different doses 250mg/kg and 500mg/kg were administered to the animals. The results showed that both doses had significant reduction in inflammatory condition but dose 500mg/kg showed maximum inflammatory reduction on comparing with control and standard treated groups.


Cite this article:
Mamta Tiwari, Pushpraj S Gupta, Nisha Sharma. A Preliminary Study on In Vitro Antioxidant and In Vivo Anti-Inflammatory Activity of Cissus quadrangularis Linn. Research Journal of Pharmacy and Technology. 2021; 14(5):2619-4. doi: 10.52711/0974-360X.2021.00461

Cite(Electronic):
Mamta Tiwari, Pushpraj S Gupta, Nisha Sharma. A Preliminary Study on In Vitro Antioxidant and In Vivo Anti-Inflammatory Activity of Cissus quadrangularis Linn. Research Journal of Pharmacy and Technology. 2021; 14(5):2619-4. doi: 10.52711/0974-360X.2021.00461   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-45


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