Author(s): Chinmaya Keshari Sahoo, Amiyakanta Mishra, Amaresh Prusty, S. Ram Mohan Rao, Jimidi Bhaskar

Email(s): sahoo.chinmaya83@gmail.com

DOI: 10.52711/0974-360X.2021.00456   

Address: Chinmaya Keshari Sahoo1*, Amiyakanta Mishra1, Amaresh Prusty1, S. Ram Mohan Rao2, Jimidi Bhaskar3
1Department of Pharmaceutics, College of Pharmaceutical Sciences,
(Affiliated to Biju Patnaik University of Technology), Puri, Odisha.
2Department of Engineering, Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia.
3Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri Kothagudem, Telangana.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
The present study was undertaken to develop floating tablets of lamivudine. The tablets were prepared by direct compression method. The prepared tablets were evaluated for pre compression parameters, post compression parameters, in vitro drug release study and in vitro buoyancy study. Among the prepared formulations F4 batch show 90.98% drug release in 12 h. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, and Korsmeyer Peppas. The result of optimized formulation releases drug up to 12 h in a controlled manner and follows Higuchi kinetics. Short term stability study at 40±2ºC/75±5% RH for three months on the best formulation was performed showing no significant changes in thickness, hardness, friability, drug content and in vitro drug release.


Cite this article:
Chinmaya Keshari Sahoo, Amiyakanta Mishra, Amaresh Prusty, S. Ram Mohan Rao, Jimidi Bhaskar. Development and Evaluation of Floating Tablets of Lamivudine. Research Journal of Pharmacy and Technology. 2021; 14(5):2593-7. doi: 10.52711/0974-360X.2021.00456

Cite(Electronic):
Chinmaya Keshari Sahoo, Amiyakanta Mishra, Amaresh Prusty, S. Ram Mohan Rao, Jimidi Bhaskar. Development and Evaluation of Floating Tablets of Lamivudine. Research Journal of Pharmacy and Technology. 2021; 14(5):2593-7. doi: 10.52711/0974-360X.2021.00456   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-40


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3.    Sahoo CK, Rao SRM, Sudhakar M. Development and evaluation of controlled release formulation of lamivudine based on microporous osmotic tablet technology using fructose as osmogen. Indonesian Journal of Pharmacy 2017; 28(3): 168-178.
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5.    Sahoo CK, Rao SRM, Sudhakar M, Bhaskar J. Advances in granulation technology. Research J. Pharm. and Tech. 2016;9(5): 571-580.
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