Author(s): Deepika Yadav, Avijit Mazumder, Roop K Khar

Email(s): deepikabsaip@gmail.com

DOI: 10.52711/0974-360X.2021.00420   

Address: Deepika Yadav1*, Avijit Mazumder2, Roop K Khar1
1B. S. Anangpuria Institute of Pharmacy, Faridabad Haryana.
2Institute of Pharmacy, Noida Institute of Engg. and Technology, Greater Noida.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Piperine a bio active constituent isolated from pepper (Piper nigrum and Piper longum L.) is a naturally occurring alkaloid have validated for several health effects and valuable therapeutic effects. However, its biological applications are limited due to its poor aqueous solubility. This emphasizes on the development of new drug delivery system for piperine to improve its in-vivo bioavailability. The present study reports the development and characterization of mucoadhesive nanoemulsion (MNE) containing piperine. MNE formulations were prepared using titration method and characterized in relation to appearance, globule size, zeta potential, thermodynamic stability testing, Ex-vivo evaluation and in-vitro drug permeation study. The MNE of piperine have small globule size (? 150nm) and positive zata potential. The spherical surface was confirmed from TEM. pH of MNE was compatible with nasal administration. In vitro release of MNE system in nasal mucosal membrane demonstrated prompt and effective release with more than 75 % of drug release in 4 h.


Cite this article:
Deepika Yadav, Avijit Mazumder, Roop K Khar. Preparation and Characterization of Mucoadhesive Nanoemulsion containing Piperine for Nasal Drug Delivery System. Research Journal of Pharmacy and Technology.Research Journal of Pharmacy and Technology. 2021; 14(5):2381-6. doi: 10.52711/0974-360X.2021.00420

Cite(Electronic):
Deepika Yadav, Avijit Mazumder, Roop K Khar. Preparation and Characterization of Mucoadhesive Nanoemulsion containing Piperine for Nasal Drug Delivery System. Research Journal of Pharmacy and Technology.Research Journal of Pharmacy and Technology. 2021; 14(5):2381-6. doi: 10.52711/0974-360X.2021.00420   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-4


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2.    Shailendra Wadhwa, Sarita Singhal and Swati Rawat. Bioavailability Enhancement by Piperine: A Review. Asian Journal of Biomedical and Pharmaceutical Sciences. 2014; 04 (36): 1-8.
3.    Song Li, Che Wang, Minwei Wang, Wei Li, Kinzo Matsumoto and YiyuanTang. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sciences. 2007; 80(15): 1373-1381.
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