Author(s): Wai Wai Phyo Nwe, Aye Mya Mya Thwin, Myat San Yi, Khin Than Yee, San Thitsa Aung, Ma Saung Oo, Nor Iza Binti A. Rahman, Mya Mya Thwin

Email(s): drmyamyathwin2011@gmail.com

DOI: 10.52711/0974-360X.2021.00442   

Address: Wai Wai Phyo Nwe1*, Aye Mya Mya Thwin3, Myat San Yi4, Khin Than Yee5, San Thitsa Aung2, Ma Saung Oo2, Nor Iza Binti A. Rahman2, Mya Mya Thwin2*
1Department of Physiology, University of Medicine, Magway, Yangon Myanmar.
2Medical Faculty, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
3University of Medicine 1, Yangon Myanmar.
4Department of Obstretrics and Gyanecology, University of Malaysia, Sarawak.
5Department of Paraclinical Sciences, University of Malaysia, Sarawak.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
The cardiovascular risk evidentially found to have an association with disparities of the dipper and non-dipper hypertension. There is less celerity with regard to mechanism of diurnal blood pressure variations and related disorders. The serum uric acid and AIP are considered as cardiovascular risk factors. The current study aims to determine and compare serum uric acid level and atherogenic index of plasma (AIP) in dipper and non-dipper normotensive subjects. The study population is 64 healthy normotensive subjects (32 dippers and 32 non-dippers), age between 30-55 years. The subjects were identified into dippers and non-dippers by using ambulatory blood pressure monitoring device (Spacelabs 90207, USA). After identifying dipping status of the subjects, uric acid, triglycerides and HDL cholesterol were measured. AIP was calculated by using formula (log [TG/HDL]). Median (interquartile range) of serum uric acid in the dipper group was 5.08mg/dl (4.12-5.66) and the non-dipper group was 5.27mg/dl (4.63-6.33). The median (interquartile range) for AIP was 0.24 (0.05-0.38) in the dipper group and 0.48 (0.32-0.67) in the non-dipper group. The median (interquartile range) of uric acid and AIP in the non-dipper group was significantly higher than that of dipper group (p<0.05). This study observed in even normotensive subjects, the non-dipper group has significantly higher serum uric acid and AIP than that of dipper group. These cardiovascular risk factors increased in non-dipper group compared to dipper group. The study come out with concluded that non-dipper group had higher cardiovascular risk than dipper group even in normotensive healthy subjects.


Cite this article:
Wai Wai Phyo Nwe, Aye Mya Mya Thwin, Myat San Yi, Khin Than Yee, San Thitsa Aung, Ma Saung Oo, Nor Iza Binti A. Rahman, Mya Mya Thwin. Serum Uric Acid, Lipid Profile and Atherogenic Index of Plasma in Dipper and Non-dipper Normotensive Subjects. Research Journal of Pharmacy and Technology. 2021; 14(5):2511-6. doi: 10.52711/0974-360X.2021.00442

Cite(Electronic):
Wai Wai Phyo Nwe, Aye Mya Mya Thwin, Myat San Yi, Khin Than Yee, San Thitsa Aung, Ma Saung Oo, Nor Iza Binti A. Rahman, Mya Mya Thwin. Serum Uric Acid, Lipid Profile and Atherogenic Index of Plasma in Dipper and Non-dipper Normotensive Subjects. Research Journal of Pharmacy and Technology. 2021; 14(5):2511-6. doi: 10.52711/0974-360X.2021.00442   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-26


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