Author(s): Dewa Ayu Swastini, I Nyoman Krisna Udayana, Cokorda Istri Sri Arisanti

Email(s): ayu_swastini@unud.ac.id

DOI: 10.52711/0974-360X.2021.00437   

Address: Dewa Ayu Swastini1*, I Nyoman Krisna Udayana1, Cokorda Istri Sri Arisanti2
1Laboratory of Pharmacology and Clinical Pharmacy, Department of Pharmacy,
Faculty of Mathematic and Sciences, Udayana University, Bali, Indonesia 80361.
2Laboratory of Technology Pharmacy, Department of Pharmacy,
Faculty of Mathematic and Sciences, Udayana University, Bali, Indonesia 80361.
*Corresponding Author

Published In:   Volume - 14,      Issue - 5,     Year - 2021


ABSTRACT:
Background: Mangosteen peel (Garcinia mangostana)L., binahong leaf (Anredera cordifolia (Ten.)), and centella herb (Centella asiatica) have been shown to have activity in each phase of burn healing process. Formulating these three plants extract into cold cream preparations is expected to increase the healing activity of burns. Objective: This study aimed to prove the efficacy of the cold cream combination of these plants by examining in vivo burn healing activity using a deep second-degree burn rat model. Materials and Methods: Rat were divided into nine experimental groups (normal, saline solution, silver sulfadiazine, cold cream base, each extract, combination of three extracts, and coldcream combination of three extracts). The burn activity was assessed by inflammatory cell, agiogenesis and collagen formation through histopathological examination. Results: Cold cream combination of mangosteen peel, binahong leaf, and centella herb enhanced the burn wound healing as indicated by progressive improvement in wound healing during 21 days after treatment. Histological result showed that coldcream combination group can reduced inflammatory cell infiltration and increased collagen significantly (p = 0.05), in the other hand same as normal control, but has no effect on angiogenesis. Conclusion: Based on these results, cold cream combination of mangosteen peel, binahong leaf, and centella herb enhanced has a potential effect as an burn healing agent.


Cite this article:
Dewa Ayu Swastini, I Nyoman Krisna Udayana, Cokorda Istri Sri Arisanti. Cold cream combination of Garcinia mangostana L. Anredera cordifolia (Ten.) and Centella asiatica extracts on Burn Healing Activity Test. Research Journal of Pharmacy and Technology. 2021; 14(5):2483-6. doi: 10.52711/0974-360X.2021.00437

Cite(Electronic):
Dewa Ayu Swastini, I Nyoman Krisna Udayana, Cokorda Istri Sri Arisanti. Cold cream combination of Garcinia mangostana L. Anredera cordifolia (Ten.) and Centella asiatica extracts on Burn Healing Activity Test. Research Journal of Pharmacy and Technology. 2021; 14(5):2483-6. doi: 10.52711/0974-360X.2021.00437   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-21


REFERENCES:
1.    World Health Organization. The Global Burden of Disease: 2004 Update. Geneva: WHO; 2008.
2.    Wild T, Rahbarnia A, Kellner M, Sobotka L, Eberlein T. Basics in nutrition and wound healing. Nutrition. 2010; 26:862-866. DOI: 10.1016/j.nut.2010.05.008
3.    Shah A, Amini-Nik S. The role of phytochemicals in the inflammatory phase of wound healing. International Journal of Molecular Sciences. 2017; 18.
4.    Poeloengan, M and Praptiwi. 2010. Antibacterial Activity Test of Mangosteen (Garcinia mangostana Linn) Skin Extract. Health Research and Development Media. 2010; 20 (2): 65-69.
5.    Paju, N., V. Y. Yamlean., N. Kojong. Test Effectiveness of Binahong (Anredera cordifolia (Ten.) Steenis) Extract Ointment in Rabbits (Oryctolagus cuniculuc) Infected by Staphylococcus aureus Bacteria. Pharmacon Pharmaceutical Scientific Journal - UNSRAT. 2013 Vol. 2. No. 01. 2302-2493.
6.    Miladiyah, I. and R. P. Bayu.. Ethanolic Extract of Anredera cordifolia (Ten.) Steenis Leaves Improved Wound Healing in Guinea Pigs. Universa Medicina. 2012; Vol. 31 (1): 1-7.
7.    Maquart, F.X., G. Bellon, P. Gillery, Y. Wegrowski, and J.P. Borel. Stimulation of Collagen Synthesis in Fibroblast Cultures by a Triterpene Extracted From Centella asiatica. Connective Tissue Res. 1990;  (24): 107-120.
8.    Schneider, M.J. dan W.A. Ritschel. 1. In Vitro and in Vivo Evaluation of Cooling Effect of Cold Creams. J. Soc. Cosmet. Chem. 1972; 23, 347-358.
9.    Ansel, H. C. Introduction to Pharmacy Dosage Forms. Fourth Edition. Jakarta: University of Indonesia Publishers. 2008. 504
10.    Nganlasom, J., T. Suttitum., D. Jirakulsomchok., A. Puapairoj.. Effect of Centella  asiatica Linn. Leaves and Garcinia Mangostana Linn. Hull on the Healing of Dermal Wounds in Diabetic Rats. Srinagarind Med J.2008; : 23 (4): 402-407.
11.    Ministry of Health Republic of Indonesia, Monograph of Indonesian Medicinal Plant Extracts, Volume 1,  Jakarta: Food and Drug Supervisory Agency Republic of Indonesia, Indonesia 2004.
12.    Windriyanti, Y. L., D. P. Wahyuningrum., M. Murukmihadi. Effect of Differences in Concentration of Ethanol Extract of Bengkuang Bulbs (Pachyrrhizus erosus, Urb) in Cream Preparations on Physical Properties. Journal of Pharmaceutical Sciences and Clinical Pharmacy. 2007; Vol. 4. No. 1
13.    Wang, J., D. Li., F. Xia., J. han., Y. Y. Tu., X. Y. Huang. Histological and Biomechanical Evaluation of the Preserved Degeenerative Dermis in Rat Autologous Skin Transplant Models After a Deep Second Degree Burn. Scand. J. Lab. Anim. Sci. 2009; 36(2): 139-145.
14.    Juniatito, V and B. F. Prasetyo. Gel Preparation Activity of Aloe Vera Extract (Aloe barbadensis Mill) in the Healing Process of Mice Wounds (Mus Musculus albinus). J. II. Pert. Indon. 2006; 11 (1).
15.    Voravuthikunchai and Kitpipit. Activity of Medicinal Plant Extracts Againts Hospital Isolates of Methicillin-Resistant Staphylococcus aureus. CMI. 2005; 11(6): 493-512
16.    Mehta, M., P. Dutta, V. Gupta. Bacterial Isolates from Burn Wound Infections and That Antibiograms: a Eight-Year Study. Indian J. Plast Surg.2007; 40(1): 25-28.
17.    Sunilson et al.. Antibactrial and Wound Healing Activities of Melastoma malabathricum Linn. Afr. J. Infect. Dis. 2008; 2(2) Pp 68-73.
18.    Darsana, O., N. K. Besung. H. Mahatmi. Potential of Binahong (Anredera cordifolia (Tenore) Steenis) Leaves in Inhibiting the Growth of Escherichia coli Bacteria by In Vitro. Indonesia Medicus Veterinus. 2012; 1 (3): 337-351.
19.    Febram, B., L. Wientarsih., B. Pontjo. 2010. Activity of Ointment Extract of Ambon Banana Tree Trunk (Musa paradisica var sapientum) in the Wound Healing Process of Mice. MOT. 2010; 15 (3): 121-137.
20.    Morisaki, N., S. Watanabe., M. Tezuka., M. Zenibayashi., R. Shiina., N. Koyama., T. Kanzaki., Y. Saito. Mechanism of Angiogenic Effects of Saponin from Ginseng Radix rubra in Human Umbilical Vein Endothelial Cells. British Journal of Pharmacology.1995; 115: 1188-1193.
21.    Tarigan and Pamila. Treatment for Moist Wound Healing Wounds. Jakarta: Faculty of Science Nursing University of Indonesia. 2007
22.    Frisca, C., T. Sardjono., F. Sandra. Angiogenesis: Pathophysiology and Clinical Applications. JKM. 2009; 8 (2): 174-187.
23.    Fisher, G. J., S. Kang., J. Varani., Z. B. Csorgo., Y. Wan., S. Datta., J. J. Voorhees. Mechanisms of Photoaging and Chronological Skin Aging. Arch. Derm. 2002;  138(11):1462 1470.
24.    Swastini, D.A., Samirana, P.O., Warditiani, N.K., Sandi, K.L.A. Anti-Gastric Ulcer Mechanism of Anredera scandens (L.) Moq Leaves Extract.  J. Pharm. Sci. and Res. 2019; Vol. 11(8), 2019, 2833-2837

Recomonded Articles:

Author(s): Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV, Joshi SB

DOI: Not Available         Access: Open Access Read More

Author(s): Tejashree N. Hagawane, Aashish M. Mahuvakar, Rajiv V. Gaikwad, Nilima A. Kshirsagar

DOI: Not Available         Access: Open Access Read More

Author(s): Widjiati1, Dewita, Viski F Hendrawan, Kusuma E Purwantari, Syuhuud A Wajdi, Ahmad B Zulfarniasyah, Ainun S Putri, Mitha A Rahmawati, Maulana F Al-Ilmi

DOI: 10.5958/0974-360X.2018.00160.9         Access: Open Access Read More

Author(s): S. Gupta, A. M. Shaikh, B. Mohanty, P. Chaudhari, P. B. Parab, K. G. Apte

DOI: 10.5958/0974-360X.2020.00325.X         Access: Open Access Read More

Author(s): Sam Mirfendereski, Arash Shabani, Ayoob Rostamzadeh, Daryoush Fatehi

DOI: 10.5958/0974-360X.2017.00312.2         Access: Open Access Read More

Author(s): P. Manimekalai, P. Maheshwari, R. Velmurugan, M. Gurumoorthy, S. Hansraj Kumar, G. Vijayakumar

DOI: 10.5958/0974-360X.2018.00098.7         Access: Open Access Read More

Author(s): Dayanand Reddy G, Bernard Mefi M, Bharathy H, Narasimha Kumar GV, Chitikela P Pullaiah, Ganesan R, Sathiya Rajeswaran P

DOI: 10.5958/0974-360X.2018.00622.4         Access: Open Access Read More

Author(s): Adryan Fristiohady, Wahyuni Wahyuni, Muhammad Ilyas Yusuf, Fadhliyah Malik, La Ode Muhammad Julian Purnama, Mentarry Bafadal, Mesi Leorita, Asriullah Jabar, Muhammad Hajrul Malaka, I Sahidin

DOI: 10.5958/0974-360X.2020.00807.0         Access: Open Access Read More

Author(s): Saikhu Akhmad Husen, Muhamad Frendy Setyawan, Muhammad Farraz Syadzha, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, Arif Nur Muhammad Ansori, Mochammad Amin Alamsjah, Zulfa Nailul Ilmi, Pugar Arga Cristina Wulandari, Pratiwi Pudjiastuti, Khalijah Awang, Dwi Winarni

DOI: 10.5958/0974-360X.2020.00491.6         Access: Open Access Read More

Author(s): Fahad Khalid Aldhafiri, Balakrishnan Santhanaraj, Gokulan Selvam, Khader Syed Zameer Ahamed, Ramasamy Subbaiya, Suriya Kumaresan, Ponnusamy Ponmurugan.

DOI: 10.5958/0974-360X.2017.00024.5         Access: Open Access Read More

Author(s): Huda F. Hasan, Salema L. Hassan, Oday K. Luaibi

DOI: 10.5958/0974-360X.2019.00806.0         Access: Open Access Read More

Author(s): Amruta V. Yadav, Mohd. Bashar Momin, Md. Awais Panjwani

DOI: 10.5958/0974-360X.2020.00559.4         Access: Open Access Read More

Author(s): S. S. Sheeba Tabassum, C. Rajaram1, S. Nelson Kumar, R. Manohar, K. Ravindra Reddy

DOI: 10.5958/0974-360X.2020.00101.8         Access: Open Access Read More

Author(s): Deepa B, Swathi Acharya, Rajendra Holla

DOI: 10.5958/0974-360X.2020.00144.4         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags