ABSTRACT:
Renal function tests are commonly used in clinical practice to look for renal disease, the most common includes the serum urea, uric acid and creatinine. Heart failure patients have a higher incidence of renal function test abnormalities than individuals who do not have heart failure disease. Fifty subjects of adults (male) were divided in to two groups, 25 subjects (healthy) as control (group1) and 25 subjects with heart failure (group 2). Our results indicate that serum uric acid, urea, and creatinine values were significantly elevated (P=0.05) in patients group (2) compared with healthy group (1). The results also showed, the effect of age categories on uric acid blood urea nitrogen and creatinine values (P=0.05) and there were no significant differences between age (41-60) years and (61-80) years. This study also shows a strong correlation between serum uric acid, urea and creatinine values (P=0.05) in heart failure patients. Conclusion: It concluded from the above finding that there was effect of heart failure disease on renal function levels.
Cite this article:
Jinan Hussein Murtadha, Iman Hashim Abdul Razzaq. Association of Serum Renal Function Levels with Heart Failure Disease in Iraqi Patients. Research Journal of Pharmacy and Technology. 2021; 14(5):2464-6. doi: 10.52711/0974-360X.2021.00433
Cite(Electronic):
Jinan Hussein Murtadha, Iman Hashim Abdul Razzaq. Association of Serum Renal Function Levels with Heart Failure Disease in Iraqi Patients. Research Journal of Pharmacy and Technology. 2021; 14(5):2464-6. doi: 10.52711/0974-360X.2021.00433 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-5-17
REFRENCES:
1. Johan, P.; Markka, S.; Keijo, P.; Kari, P.; Krista, S.; Reijo, S. and Veli-pekka, H. Markers of renal function and acute kidney injury in acute heart failure: definitions and impact on outcomes of the caridiorenal syndrome. European Heart Journal. 2010; 31: 2791 – 2798.
2. Shlipak, M.; Smith, G.; Rathore, S.; Massie, B. and Krumboiz, H. Renal function, digoxin therapy, and heart failure outcomes: evidence from the digoxin intervention group trial. J Am SocNephrol2004; 15(8): 195-203.
3. Naruse, H.; Isha, J.; Hishida, H.; Ishikawa, M.; Okumura, M. and Ozaki, Y. Cystatincin acute heart failure without advanced renal impairment. Am J med. 2009; 122: 566-573.
4. Curtis, B. and Parfrey, P. Congestive heart failure inchronic kidney disease :disease – specific mechanisms of systolic and diastolic heart failure and management. Cardiol, clin. 2005; 23: 275-284.
5. Maya, G.; Abel, R.; Fadi, M. and Marcose, G. Renal dysfunction in heart failure is due to congestion but not low output. Clin. Cardiol. 2011; 34(2): 113-116.
6. Mitchell, P.; Marke, D.; Donkor, A.; Shote.; A.; McDonagh, T.; Hardman, S. et al. National heart failure auditapril 2013 – 2014. National Institute for Cardiovascular outcomes research. 2015; 15(2): 441-8.
7. Ezekowitz, J.; McAlister, F.; Humphries, K.; Narrise, C.; Tonelli, M.; Ghali, W. etal. The association among renal insufficiency, pharmacotherapy and outcomes G, 427 patients with heart failure and coronary artery disease. J. Am. Coll. Cardiol. 2004; 44: 1587-1592.
8. Smith, G.; Lichman, J.; Bracken, M.; Shlipak, M.; Phillips, C. and Dicapua, P. et al. Renal impairment and outocmes in heart failure: systematic review and metal– analysis. J Am Coll Cardiol 2006; 47: 1987-1996.
9. Corsh, J.; Astor, B.; Greene, T.; Eknoyan, G. and Levey, A. Prevalence of chronic kidney disease and decreased kidney function in the adult us population. Third national health and nutrition examination survey. Am J kidney Dis. 2003; 41: 1-12.
10. Ali, A and Rath, C. Epidemiology of chronic kidney disease in heart failure. Heart Fail. Clin. 2010; 4(4): 387-399.
11. Michel, A.; Martin-Perez, M.; Ruigomez, A. and Garcia, R. Incidence and risk factors for sever renal impairment after first diagnosis of heart failure: a cohort and nested case – control study in UK general practice. Int J Cardiol. 2016; 207: 252-257.
12. Foster, M., Rawlings, M.; Marrett, E.; Neff, D.; Willis, K.; and Inker, L. et al. Cardiovascular risk factor burden treatment and control among adults with chronic kindey disease in the united states. Am Heart J. 2013; 66: 150 – 156.
13. Heywood., J.; fonarow, G.; Costanzo, M, M.; Mathur, V.; Wigneswaran, J. and Wynne, J. High prevalence of renal dysfunction and its impact on outcome in 118, 465 patients hospitalized with acute decompensated heart failure:a report from the ADHER data base. J Card Fai 2007. 13: 422-430.
14. Nerpin, E., Ingelsson., E.; Riserus, U.; Sundstrom, J.; Andren, B.; Jobs, E. et al. The association between glomerular filtration rate and left ventricular function in two in dependent community – based cohorts of elderly. Nephrology Dialysis Transplantation. 2014; 29: 2069-2074.
15. Oyedeji, A.; Balogum, M.; Akintomide, A.; Adebayo, R.; Ajayi, O. and Ogunyemi, S. et al. The significance of mild renal dysfunction in chronic heart failure. West Aft J Med. 2011; 30: 442-446.
16. Kentaro, J.; Yuichiro, M.; Shintaro, H.; Yuya, M. and Kensuk, S. etal. Persistent high blood urea nitrogen level is associated with increased acute heart failure. ESC Heart Failure. 2017; 4 (4): 545-553.
17. SAS. Statistical analysis system, user's guide. Statistical-Version 9. 1th ed. 2012. SAS. Inst. Inc. Cary. N. C. USA.
18. Ahmed, A.; David, W.; Mark, A. and Munir, P. Renal function monitoring in heart failure- what is the optional frequency? Anarrative review. Br J Clinpharmacol2018.; 84(1): 5-17.
19. Klein, L.; Massie.; and Leimberger, J. et al. Admission of changes in renal function during hospitalization for worsening heart failure predictposted charge survival: results the outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure. CircHeart Fail. 2008; 1: 25-33.
20. Miura, M.; Sakata, Y.; Nochioka; K.; Tokahashil J. and Miyata, S. et al. Prognostic impact of blood urea nitrogen changes during hospitalization in patients with acute heart failure syndrome. Circ J. 2013; 7: 1221-1228.
21. Kojima, S.; Sakamota, T.; Ishihara, M.; Kimura, K. and Miyazaki et al. Prognostic usefullness of serum uric acid after acute myocardial infarction(the Japanese Coronary Syndrome Study). Am Jcardiol. 2005; 96(4): 489-495.
22. Grayson, p.; Kim, S.; Lavalley, M. and Choi, H. Hyperuricemia and incident hypertension systematic review and meta- analysis. Arthritis Care Res. 2010; 63(1): 102-110.
23. Adnan, K.; Mohammed, H.; Sarbiland, K. Umama, S. and Sanan, A. Serum uric acid level in the severity of congestive heart failure (CHF). Pak J med Sci. 2017; 33(2): 330-334.
24. Seong, W. and Kyu, H. Renal dysfunction in acute heart failure. Korean Circ J. 2011; 41(10): 565-574.
25. Testani, J.; Coca, S.; Mccauley, B.; Shannon, R. and Kimmel, S. Impact of changes in blood pressure during the treatment of acute decompensate heart failure on renal and clinical outcomes. Eur J Heart Foil. 2011; 13: 877-884.
26. Voors, A.; Davison, B.; Felker, G.; Ponikowshi, P. and Metra, M. et al. Pre-relax AHF study group early drop in systolic blood pressure and worsening renal function in acute heart failure. Eur J Heart Fail. 2011; 13: 961- 967.