Author(s): Vybhava Krishna, Veena Nayak, Arvind Kumar Pandey, Sweenly V Sunny, K L Bairy

Email(s): veena.nayak@manipal.edu

DOI: 10.52711/0974-360X.2021.00333   

Address: Vybhava Krishna1, Veena Nayak2*, Arvind Kumar Pandey3, Sweenly V Sunny4, K L Bairy5
1Post Graduate, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
2Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
3Associate Professor, Department of Anatomy, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
4Post Graduate, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
5Professor, Department of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Sciences, University, Ras Al Khaimah, UAE.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
Objective: Escitalopram is one of the commonly used antidepressants. The use of antidepressants is increasing throughout the world. There is minimal evidence on the effect of chronic administration of escitalopram on scopolamine-induced memory impairment. So, the current study was aimed at evaluating the effects of chronic escitalopram administration on learning and memory in Wistar albino rats. Methods: Twenty-four adult male Wistar rats were randomly assigned equally to four groups, i.e., Control, scopolamine and two doses of escitalopram. The test drug was given orally for 28 days. Scopolamine was given single dose intraperitoneally. The rats were subjected to two behavioural paradigms, i.e., water maze and T maze. After behavioural tests, the rats were sacrificed. Brain acetylcholinesterase level was estimated, and histopathological examination was done. Results: Higher dose of escitalopram was able to reverse scopolamine-induced memory impairment both in the water maze and T maze. Escitalopram at this dose could also reverse the scopolamine-induced increase in brain acetylcholinesterase and histopathological changes. Conclusion: Chronic administration of escitalopram reversed scopolamine-induced memory impairment in a dose-dependent manner by enhancing cholinergic activity.


Cite this article:
Vybhava Krishna, Veena Nayak, Arvind Kumar Pandey, Sweenly V Sunny, K L Bairy. Chronic treatment with Escitalopram Reversed Scopolamine-induced Memory Impairment by enhancing Cholinergic activity in Wistar albino Rats. Research Journal of Pharmacy and Technology. 2021; 14(4):1887-2. doi: 10.52711/0974-360X.2021.00333

Cite(Electronic):
Vybhava Krishna, Veena Nayak, Arvind Kumar Pandey, Sweenly V Sunny, K L Bairy. Chronic treatment with Escitalopram Reversed Scopolamine-induced Memory Impairment by enhancing Cholinergic activity in Wistar albino Rats. Research Journal of Pharmacy and Technology. 2021; 14(4):1887-2. doi: 10.52711/0974-360X.2021.00333   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-9


REFERENCES: 
1. Ganguli M. Depression, cognitive impairment, and dementia: Why should clinicians care about the web of causation? Indian J Psychiatry. 2009; 51 Suppl 1: S29-34. 
2. Saldanha D. Mental Health : An Indian Perspective 1946-2003. Med J Armed Forces. 2005; 61(2):205
3. Hemels ME, Koren G, Einarson TR. Increased Use of Antidepressants in Canada: 1981–2000. Ann Pharmacother. 2002; 36(9): 1375–9.
4. Lobo AO, Serrano CL. El incremental en la prescripción de antidepressives.  Atención Primaria, 2005;35(3): 152–5.
5. Bijl D, Adegrave HJ, De Haan M. Antidepressant prescription for depression in general practice in the Netherlands. Pharm World Sci. 2001;23(2): 46–9.
6. Kayalvili Sanmugam. Depression is a Risk Factor for Alzheimer Disease- Review. Research J. Pharm. and Tech. 8(8): August, 2015; Page1056-1058
7. Sangroyangla, Temjentula, Temjenyangla Imchen, Tsungrosenla Longkumer, Vizayieno, Khumjanbeni Murry. Prevalence of Depression and the associated risk factors among the Elderly. Asian J. Nursing Education and Research. 2019; 9(4): 552-554.
8. Manpreet Kaur, Sukhpreet Kaur, Rajwant Kaur. Correlation of Depression and Quality of life among rural elderly. Int. J. Adv. Nur. Management. 2016; 4(4): 323-326.
9. Narasingrao, G. Radhakrishnan, Anuchithra. A Study to Assess the Knowledge and Attitude on care of Elderly Depression and Cognitive Impairment among Adults Residing in Selected Villages of Vellore rural PHC, Belgaum. Int. J. Nur. Edu. and Research. 2017; 5(1): 99-101.
10. Solanki Divya K, Hasumati Raj, Prajapati Neelam. Combined Treatment of Aripiprazole and Escitalopram Oxalate Therapy to Treat Major Depressive Disorders. Asian J. Res. Pharm. Sci. 2016; 6(2): 113-115.
11. Frazer A. Pharmacology of antidepressants. J Clin Psychopharmacol. 1997; 17 Suppl 1: 2S–18S.
12. Fuller RW. Serotonin uptake inhibitors: uses in clinical therapy and in laboratory research. In: Jacker E.(eds)  Progress in Drug Research. Volume 45. Basel: Birkhauser Verlag 1995.p.167–204.
13. Hyttel J. Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs). Int Clin Psychopharmacol. 1994; 9 Suppl 1: 19–26.
14. Stahl SM. Essential psychopharmacology : neuroscientific basis and practical application. 4th edn. Cambridge: Cambridge University Press; 2000.p. 601.
15. Altman HJ, Nordy DA, Ogren SO. Role of serotonin in memory: facilitation by alaproclate and zimeldine. Psychopharmacology. 1984;84(4): 496–502.
16. Hong E, Meneses A. The activation of serotonergic 5-HT1A presynaptic receptors or an enhancement of 5-HT postsynaptic activity increase learning. Proc West Pharmacol Soc. 1995; 38:85–6. 
17. Meneses A. 5-HT system and cognition. Neurosci Biobehav Rev. 1999; 23(8): 1111–25.
18. Izquierdo I, Medina JH, Izquierdo LA, Barros DM, de Souza MM, Mello e Souza T. Short- and Long-Term Memory Are Differentially Regulated by Monoaminergic Systems in the Rat Brain. Neurobiol Learn Mem. 1998; 69(3): 219–24. 
19. Lawlor BA, Sunderland T, Mellow AM, Hill JL, Molchan SE, Murphy DL. Hyperresponsivity to the serotonin agonist m-chlorophenylpiperazine in Alzheimer’s disease. A controlled study. Arch Gen Psychiatry. 1989; 46(6): 542–9. 
20. Mongeau R, Blier P, de Montigny C. The serotonergic and noradrenergic systems of Res Brain Res Rev. 1997; 23(3):145–95. 
21. Vanderwolf CH. Near-total loss of “learning” and “memory” as a result of combined cholinergic and serotonergic blockade in the rat. Behav Brain Res. 1987; 23(1): 43–57.
22. Brown HD, Amodeo DA, Sweeney JA, Ragozzino ME. The selective serotonin reuptake inhibitor, escitalopram, enhances inhibition of prepotent responding and spatial reversal learning. Journal of psychopharmacology. 2012;26(11): 1443-55.   
23. Antonova E, Parslow D, Brammer M, Simmons A, Williams S, Dawson GR, et al. Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris Water Maze. J Psychopharmacol. 2011; 25(9): 1256–65.
24. Shetty S, Hariharan A, Shirole T, Jagtap AG. Neuroprotective potential of escitalopram against behavioral, mitochondrial and oxidative dysfunction induced by 3-nitropropionic acid. Annals of neurosciences. 2015; 22(1):11
25. Zaki HF, Abd-El-Fattah MA, Attia AS. Naringenin protects against scopolamine-induced dementia in rats. Bull Fac Pharmacy, Cairo Univ. 2014; 52(1): 15–25.
26. Vorhees C V, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 2006;1(2): 848–58. 
27. Deacon RMJ, Rawlins JNP. T-maze alternation in the rodent. Nat Protoc. 2006; 1(1): 7–12.
28. Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7(2): 88–95.
29. L.V. Siva Athitya, V. Muthu Vijai Bharath, Jayshree Nellore, P. Prakash. Screening of Gracilaria corticata Extracts for Acetylcholinesterase Inhibitory Activity. Research J. Pharm. and Tech 2018; 11(9): 3848-385
30. Karthik Dhananjayan, Arunachalam Sumathy, Sivanandy Palanisamy. Molecular Docking Studies and in-vitro Acetylcholinesterase Inhibition by Terpenoids and Flavonoids. Asian J. Research Chem. 6(11): November 2013; Page 1011-1017.
31. Fan Y, Hu J, Li J, Yang Z, Xin X, Wang J, et al. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. Neurosci Lett. 2005;374(3): 222–6. 
32. Jeong EJ, Lee KY, Kim SH, Sung SH, Kim YC. Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice. Eur J Pharmacol. 2008; 588(1): 78–84. 
33. Rubio J, Dang H, Gong M, Liu X, Chen S, Gonzales GF. Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice. Food Chem Toxicol. 2007; 45(10): 1882–90. 
34. Lee B, Park J, Kwon S, Park M-W, Oh S-M, Yeom M-J, et al. Effect of wild ginseng on scopolamine-induced acetylcholine depletion in the rat hippocampus. J Pharm Pharmacol. 2010;62(2): 263–71.
35. Savaskan E, Müller SE, Böhringer A, Schulz A, Schächinger H. Antidepressive therapy with escitalopram improves mood, cognitive symptoms, and identity memory for angry faces in elderly depressed patients. Int J Neuropsychopharmacol. 2008; 11(03): 381–8. 
36. Wroolie TE, Williams KE, Keller J, Zappert LN, Shelton SD, Kenna HA, et al. Mood and Neuropsychological Changes in Women With Midlife Depression Treated With Escitalopram. J Clin Psychopharmacol. 2006; 26(4): 361–6. 
37. Couto FS , Batalha VL, Valadas JS, Data-Franca J, Ribeiro JA, Lopes L V. Escitalopram improves memory deficits induced by maternal separation in the rat. Eur J Pharmacol. 2012;695(1–3): 71–5.
38. Bondi CO, Rodriguez G, Gould GG, Frazer A, Morilak DA. Chronic Unpredictable Stress Induces a Cognitive Deficit and Anxiety-Like Behavior in Rats that is Prevented by Chronic Antidepressant Drug Treatment. Neuropsychopharmacology. 2008;33(2): 320–31. 
39. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci. 2000; 20(24): 9104–10. 
40. Bessa JM, Ferreira D, Melo I, Marques F, Cerqueira JJ, Palha JA, et al. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol Psychiatry. 2009;14(8): 764–73
41. Brown HD, Amodeo DA, Sweeney JA, Ragozzino ME. The selective serotonin reuptake inhibitor, escitalopram, enhances inhibition of prepotent responding and spatial reversal learning. J Psychopharmacol. 2012;26(11): 1443–55.
42. Schilström B, Konradsson-Geuken Å, Ivanov V, Gertow J, Feltmann K, Marcus MM, et al. Effects of S-citalopram, citalopram, and R-citalopram on the firing patterns of dopamine neurons in the ventral tegmental area, N-methyl-D-aspartate receptor-mediated transmission in the medial prefrontal cortex and cognitive function in the rat. Synapse. 2011;65(5): 357–67.
43. Console S, Bertorelli R, Russi G, Zambelli M, Ladinsky H. Serotonergic Facilitation of Acetylcholine Release In Vivo from Rat Dorsal Hippocampus via Serotonin 5-HT3 Receptors. J Neurochem. 2008; 62(6): 2254–61.

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available         Access: Open Access Read More

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

Author(s): Muhammad Hamdan, Noorhamdani AS, Masruroh Rahayu, Mohammmad Hasan Machfoed

DOI: 10.5958/0974-360X.2019.01020.5         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): J. Rubika

DOI: Not Available         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): Vandana Devi Sahu, Mukta Agrawal, Mukesh Sharma, Sandhya Chandrakar, Sujata Gupta, Garima Sharma, Kalyani Dewangan, Harsha Solanki, Manisha Majumdar, D. K. Tripathi, Amit Alexander, Ajazuddin

DOI: 10.5958/0974-360X.2016.00145.1         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags