Author(s): Noha Ibrahim, Eman S. Elzanfaly, Ahmed E. El Gendy, Said A. Hassan

Email(s): said.hassan@pharma.cu.edu.eg

DOI: 10.52711/0974-360X.2021.00332   

Address: Noha Ibrahim1, Eman S. Elzanfaly2, Ahmed E. El Gendy1, Said A. Hassan2*
1Analytical Chemistry Department, Faculty of Pharmacy, MISR International University, Cairo, Egypt.
2Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
Green chemistry is an emerging field concerned with safe practices in chemical method development. The purpose of the study is to develop a sensitive, environmentally friendly spectrofluorimetric method by studying and optimizing variables affecting the native fluorescence intensity of Moxifloxacin using experimental design approach. The analysis was divided into three phases: studying and screening the critical factors using 2-level full factorial design, optimization using central composite design and validation according to International Conference on Harmonization (ICH) guidelines. The optimal experimental conditions obtained from this study were 0.05 M phosphate buffer with an adjusted buffer pH of 9.7 and a temperature of 7.4°C±0.5, providing a sensitive measurement of MOX. The validated method providing to be linear over a range of 5-40ng/mL (r= 0.9999), precise, accurate, and robust (demonstrated by the Plackett-Burman design). It can be concluded that the validated method can be safe, optimum, and environmentally friendly alternative for the analysis of MOX.


Cite this article:
Noha Ibrahim, Eman S. Elzanfaly, Ahmed E. El Gendy, Said A. Hassan. Development, Optimization, and Validation of a Green Spectrofluorimetric method for the determination of Moxifloxacin using an Experimental design approach. Research Journal of Pharmacy and Technology. 2021; 14(4):1880-6. doi: 10.52711/0974-360X.2021.00332

Cite(Electronic):
Noha Ibrahim, Eman S. Elzanfaly, Ahmed E. El Gendy, Said A. Hassan. Development, Optimization, and Validation of a Green Spectrofluorimetric method for the determination of Moxifloxacin using an Experimental design approach. Research Journal of Pharmacy and Technology. 2021; 14(4):1880-6. doi: 10.52711/0974-360X.2021.00332   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-8


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