Author(s):
Subhashini Rajakumaran, Ruth Christiya C
Email(s):
dr.r.subashini@gmail.com , cruthcharles1988@gmail.com
DOI:
10.52711/0974-360X.2021.00394 
Address:
Subhashini Rajakumaran1*, Ruth Christiya C2
1Assistant Professor, Department of Biochemistry, D.G. Govt. Arts College for Women, Mayiladuthurai, 609001.
2Assistant Professor, PG and Research Department of Biochemistry, Rabiammal Ahamed Maideen College for Women, Tiruvarur - 610001, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 4,
Year - 2021
ABSTRACT:
Medicinal plants maintain the health and vitality of individuals, and also have potential curative effect on various diseases, including cancer. Bone cancer is the foremost cause of deaths among women worldwide. In this present study, the antiproliferative effects of methanol extracts of Euphorbia hirta L leaves was investigated on MG 63 cell line. The methanolic extract of plant exhibited significant dose dependent antiproliferative activity against MG63 cell line which was ranged between 89.43% and 20.63% at concentrations of 50µg/ml and 350µg/ml correspondingly (24 hours). Moreover, the plant found to decrease the cell viability in dose dependent manner. The results of this study show that Euphorbia hirta L is a potential source of compounds that may serve as leads for anticancer property.
Cite this article:
Subhashini Rajakumaran, Ruth Christiya C. Anti-proliferative effects of Euphorbia hirta L on the activity of cytotoxicity in bone cancer MG-63 cells. Research Journal of Pharmacy and Technology. 2021; 14(4):2221-3. doi: 10.52711/0974-360X.2021.00394
Cite(Electronic):
Subhashini Rajakumaran, Ruth Christiya C. Anti-proliferative effects of Euphorbia hirta L on the activity of cytotoxicity in bone cancer MG-63 cells. Research Journal of Pharmacy and Technology. 2021; 14(4):2221-3. doi: 10.52711/0974-360X.2021.00394 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-70
REFERENCE:
1. Zimmerman MA, Huang Q, Li F, Liu X and Li CY. Cell death–stimulated cell proliferation: A tissue regeneration mechanism usurped by tumors during radiotherapy. Semin Radiat Oncol. 2013:23(4); 288-95
2. Ferlay HR, Shin Bray F, Forman D, Mathers C and Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN2008. International Journal of Cancer.2010: 127(12); 2893–2917
3. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer.2015: 136(5); 359-86
4. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA andJemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. A cancer journal for clinicians.2018: 68(6); 394-424
5. Unni KK, Dahlin DC. Dahlin's bone tumors: general aspects and data on 11, 087 cases. 5th. Philadelphia, Penn, USA: (Lippincott-Raven, 1996)
6. Baharvand-Ahmadi B, Bahmani MP, Tajeddini M, Rafieian Kopaei and Naghdi N. An ethnobotanical study of medicinal plants administered for the treatment of hypertension. Journal of Renal Injury Prevention. 2016: 9; 123–128.
7. Valter RM, Lombardi, Iván Carrera and Ramón Cacabelos. In Vitro Screening for Cytotoxic Activity of Herbal Extracts. Evidence-Based Complementary and Alternative Medicine. Article ID 2675631.2017: 8.
8. Khatibi S, Farzaneh Taban Z, Mohammadi Roushandeh A. In Vitro Evaluation of Cytotoxic and Antiproliferative Effects of Portulaca oleracea Ethanolic Extract on on HeLa Cell Line. Gene Cell Tissue. 2017: 4(1): 13301
9. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods.1983: 65; 55-63.
10. Abbas Momtazi-borojeni A, Behbahani M, Sadeghi-aliabadi H. Antiproliferative activity and apoptosis induction of crude extract and fractions of avicennia marina. Iranian journal of basic medical sciences.2013:16(11); 1203-1210
11. Lepley DM, Li B, Birt DF, Pelling JC. The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes. Carcinogenesis. 1996 :(11); 2367 -75.