Brahamdutt, Sonia Narwal, Aditay Kumar, Manjusha Chaudhary, Vikas Budhwar
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Brahamdutt1, Sonia Narwal2, Aditay Kumar1, Manjusha Chaudhary3, Vikas Budhwar1*
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak (Haryana), India - 124001.
2Faculty of Pharmaceutical Sciences, PDM University, Bahadurgarh.
3University Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, India -136119.
Volume - 14,
Issue - 4,
Year - 2021
Background: Eutectics are basically multi-component crystalline solids closely related to solid solutions. However, the structural organization of eutectics has not been studied in as much detail as solid solutions, which are defined based on the arrangement of a major (solvent) and a minor (solute) component in the crystal lattice. Purpose: The goal of this study is basically improvement in aqueous solubility of poorly water soluble drug i.e curcumin via its eutectic formation by using salicylic acid as coformer. Material and Method: Here the eutectic mixture of curcumin and salicylic acid was prepared by solvent evaporation technique for improving the dissolution behaviour of curcumin. DSC and FT-IR spectroscopy were used as analytical techniques for characterization of eutectic mixture. Result: The DSC and FT-IR spectroscopy conformed the formation of eutectic mixture and In-Vitro dissolution studies revealed an improved dissolution behaviour for eutectic mixture (69.38 %) as compared to the pure curcumin (40.53%). Conclusion: The study conclude that binary systems improved the dissolution behaviour of poorly water soluble drugs without changing the physiochemical and pharmacological properties of concerned API.
Cite this article:
Brahamdutt, Sonia Narwal, Aditay Kumar, Manjusha Chaudhary, Vikas Budhwar. Formulation of Eutectic mixture of Curcumin with Salicylic Acid for improving its Dissolution Profile. Research Journal of Pharmacy and Technology. 2021; 14(4):1875-9. doi: 10.52711/0974-360X.2021.00331
Brahamdutt, Sonia Narwal, Aditay Kumar, Manjusha Chaudhary, Vikas Budhwar. Formulation of Eutectic mixture of Curcumin with Salicylic Acid for improving its Dissolution Profile. Research Journal of Pharmacy and Technology. 2021; 14(4):1875-9. doi: 10.52711/0974-360X.2021.00331 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-7
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