Chronic wound infections are significant medical burden as the patients have to go through severe discomfort and distress. Invasion of various pathogenic microorganisms at the injured site further leads to damage of tissue which may results in resection of the organ. Appropriate wound healing is necessary to regain the functional and anatomical status of the damaged tissue that got disturbed due to wound. Conventional antibiotics used for the treatment of infections are associated with various drawbacks such as high cost and high incidence of resistance. Moreover, the dressing used for wounds are also unable to provide adequate moisture to the injured tissue. All these factors emphasise on the development of new advanced technologies for wound care. Polyherbal formulations, which comprise of various medicinal plant extracts, exhibit antioxidant and anti-inflammatory properties and can be much better alternative to commercial antibiotics for treatment of wound infections. In the present study, wound healing potential of “Septaheal” (a Polyherbal formulation) was evaluated in Wistar albino rats using incision, excision and burn wound models. The formulation exhibited wound healing property due to its angiogenic and mitogenic potential.
Cite this article:
Rohit Kumar, Reena Gupta, Bimlesh Kumar, Bhupinder Kapoor. Wound Healing Potential of Polyherbal Formulation in Rats. Research Journal of Pharmacy and Technology. 2021; 14(4):2195-9. doi: 10.52711/0974-360X.2021.00389
Rohit Kumar, Reena Gupta, Bimlesh Kumar, Bhupinder Kapoor. Wound Healing Potential of Polyherbal Formulation in Rats. Research Journal of Pharmacy and Technology. 2021; 14(4):2195-9. doi: 10.52711/0974-360X.2021.00389 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-65
1. Shevchenko RV et al. A novel skin substitute biomaterial to treat full-thickness wounds in a burns emergency care. In Biodefence, Edited by Mikhalovsky S and Khajibaev A. Springer Dordrecht. 2011; pp. 247-255.
2. Rondas AA et al. Prevalence of chronic wounds and structural quality indicators of chronic wound care in Dutch nursing homes. International Wound Journal. 2015; 12(6): 630-635.
3. Kumar K et al. Ethnotherapeutics of Bryophyte plagiochasmaappendiculatum among the Gaddi tribes of Kangra valley, Himachal Pradesh, India. Pharmaceutical Biology. 2000; 38(5): 353-356.
4. Lazarus GS et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Archives of Dermatology. 1994; 130(4): 489-493.
5. Thomas CH. Checklist for factors affecting wound healing. Advances in Skin and Wound Care. 2011; 24(4): 192.
6. Bowler PG. Wound microbiology and associated approaches to wound management. Clinical Microbiology Reviews. 2001; 14(2): 244-269.
7. Leach MJ. Making sense of the venous leg ulcer debate: a literature review. Journal of Wound Care. 2004; 13(2): 52-56.
8. Dabiri G et al. Choosing a wound dressing based on common wound characteristics. Advances in Wound Care. 2016; 5(1): 32-41.
9. Lipsky BA and Hoey C. Topical antimicrobial therapy for treating chronic wounds. Clinical Infectious Diseases. 2009; 49(10): 1541-1549.
10. Church D et al. Burn wound infections. Clinical Microbiology Reviews. 2006; 19(2): 403-434.
11. Thakur R et al. Practices in wound healing studies of plants. Evidence-Based Complementary and Alternative Medicine. 2011; 2011: 438056.
12. Aslam MS et al. Antioxidant and wound healing activity of polyherbal fractions of Clinacanthus nutans and Elephantopus scaber. Evidence-based Complementary and Alternative Medicine. 2016; 2016: 4685246.
13. Hasan A et al. Bovine reticulum derived extracellular matrix (b-REM) for reconstruction of full thickness skin wounds in rats. Wound Medicine. 2016; 12: 19-31.
14. Garg VK and Paliwal SK. Wound-healing activity of ethanolic and aqueous extracts of Ficus benghalensis. Journal of Advanced Pharmaceutical Technology & Research. 2011; 2(2): 110-114.
15. Cai EZ et al. Creation of consistent burn wounds: a rat model. Archives of Plastic Surgery. 2014; 41(4): 317-324.
16. Velnar T et al. The wound healing process: an overview of the cellular and molecular mechanisms. Journal of International Medical Research. 2009; 37(5) 1528-1542.
17. Boyapati Land Wang HL. The role of stress in periodontal disease and wound healing. Periodontology. 2000; 44(1): 195-210.