Author(s): Babli Khatun, Venkatesh Kamath, Muddukrishna B. S., Aravinda Pai

Email(s): pai.aravind@gmail.com

DOI: 10.52711/0974-360X.2021.00382   

Address: Babli Khatun1, Venkatesh Kamath2, Muddukrishna B. S.3, Aravinda Pai1*
1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India.
2Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India.
3Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
In the present study, a series of novel substituted pyrazole chalcones and pyrazole oximes (CF 1-15) were synthesized and characterized. Logp values were determined to assess their hydrophobicity. MTT (methyl tetrazolium) assay was performed on A-549 (lung cancer) cell lines. The MTT assay results showed the effect of various substituents on the pyrazole template that could influence their cytotoxic effect. Out of the 15 compounds screened against A-549 cell lines, the compound CF-6 showed appreciable cytotoxicity against the standard doxorubicin.


Cite this article:
Babli Khatun, Venkatesh Kamath, Muddukrishna B. S., Aravinda Pai. Synthesis, Characterization and Anticancer Evaluation of Novel Analogues of Pyrazoles. Research Journal of Pharmacy and Technology. 2021; 14(4):2162-6. doi: 10.52711/0974-360X.2021.00382

Cite(Electronic):
Babli Khatun, Venkatesh Kamath, Muddukrishna B. S., Aravinda Pai. Synthesis, Characterization and Anticancer Evaluation of Novel Analogues of Pyrazoles. Research Journal of Pharmacy and Technology. 2021; 14(4):2162-6. doi: 10.52711/0974-360X.2021.00382   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-58


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