Author(s): Anjaneyulu Konuri, Kumar M R Bhat, Kiranmai S Rai, Nagamma T, Rajesh Thangarajan, Sivakumar G

Email(s): anjaneyulu.konuri@manipal.edu

DOI: 10.52711/0974-360X.2021.00381   

Address: Anjaneyulu Konuri1*, Kumar M R Bhat2, Kiranmai S Rai3, Nagamma T4, Rajesh Thangarajan5, Sivakumar G6
1Dept. of Anatomy, Manipal Tata Medical College, Jamshedpur, Manipal Academy of Higher Education, Manipal 576104, India.
2Dept. of Anatomy, Ras Al Khaimah College of Medical Sciences, RAK Medical and Health Science University, Ras Al Khaimah, UAE.
3Dept. of Physiology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal 576104, India.
4Dept. of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal 576104, India.
5Dept. of Anatomical Sciences, St. Matthew’s University School of Medicine, Grand Cayman, Cayman Islands.
6Dept. of Physiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
As impairment of memory and ischemic brain injury is more common in female of menopausal age, the current study aims to evaluate the protective role of fenugreek seed extract and choline-Docosahexaenoic acid (DHA) on cognitive behavior, oxidative stress and neurodegeneration in ovariectomized-cerebral ischemic rats. Cerebral ischemia was induced by bilateral common carotid artery occlusion (BCCAO) surgery to ovariectomized adult female wistar rats. Fenugreek, choline-DHA and combination of fenugreek with choline-DHA was supplemented for 30days after ovariectomy and continued for 14 more days after BCCAO surgery. Effect of this supplementation on learning and memory, brain oxidative stress and neurodegeneration in the CA1, CA3 hippocampal sub-regions were analyzed. Ovariectomized-cerebral ischemic rats demonstrated learning and memory impairment when subjected to passive avoidance task. Further, these rats also had increased brain oxidative stress, and neurodegeneration in CA1, CA3 sub-regions of hippocampus. Conversely, combined supplementation of fenugreek with choline-DHA to ovariectomized-cerebral ischemic rats exhibited a significant improvement in their learning and memory abilities, with reduced oxidative stress and neurodegeneration in CA1 and CA3 sub-regions of hippocampus.


Cite this article:
Anjaneyulu Konuri, Kumar M R Bhat, Kiranmai S Rai, Nagamma T, Rajesh Thangarajan, Sivakumar G. Dietary Supplementation of Fenugreek Seed Extract and Choline-Docosahexaenoic acid on Oxidative Stress and Neurodegeneration in Ovariectomized Rats with Bilateral Common Carotid Artery Occlusion. Research Journal of Pharmacy and Technology. 2021; 14(4):2153-1. doi: 10.52711/0974-360X.2021.00381

Cite(Electronic):
Anjaneyulu Konuri, Kumar M R Bhat, Kiranmai S Rai, Nagamma T, Rajesh Thangarajan, Sivakumar G. Dietary Supplementation of Fenugreek Seed Extract and Choline-Docosahexaenoic acid on Oxidative Stress and Neurodegeneration in Ovariectomized Rats with Bilateral Common Carotid Artery Occlusion. Research Journal of Pharmacy and Technology. 2021; 14(4):2153-1. doi: 10.52711/0974-360X.2021.00381   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-57


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