Author(s): Khater Ahmed Saeed AL-Japairai, Bappaditya Chatterjee, Syed Mahmood, Samah Hamed Almurisi

Email(s): bdpharmaju@gmail.com

DOI: 10.52711/0974-360X.2021.00379   

Address: Khater Ahmed Saeed AL-Japairai1,3, Bappaditya Chatterjee2,3*, Syed Mahmood1,4, Samah Hamed Almurisi3
1Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology, University Malaysia Pahang, Gambang 26300, Malaysia.
2SPP School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai, India.
3Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan 25200, Malaysia.
4Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Malaya, 50603, KL, Malaysia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan.


Cite this article:
Khater Ahmed Saeed AL-Japairai, Bappaditya Chatterjee, Syed Mahmood, Samah Hamed Almurisi. A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study. Research Journal of Pharmacy and Technology. 2021; 14(4):2139-4. doi: 10.52711/0974-360X.2021.00379

Cite(Electronic):
Khater Ahmed Saeed AL-Japairai, Bappaditya Chatterjee, Syed Mahmood, Samah Hamed Almurisi. A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study. Research Journal of Pharmacy and Technology. 2021; 14(4):2139-4. doi: 10.52711/0974-360X.2021.00379   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-55


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