Author(s): Andy Suryadi, Siswandono Siswodihardjo, Tri Widiandani, Retno Widyowati

Email(s): rr-retno-w@ff.unair.ac.id

DOI: 10.52711/0974-360X.2021.00370   

Address: Andy Suryadi1,3, Siswandono Siswodihardjo2, Tri Widiandani2, Retno Widyowati2*
1Department of Pharmacy, Faculty of Sports and Health, Gorontalo State University, Gorontalo 96128 Indonesia.
2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C UNAIR, Mulyorejo, Surabaya 60115, Indonesia.
3Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Nanizar Zaman Joenoes Building, Campus C UNAIR, Mulyorejo, Surabaya 60115 Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
Temu kunci (Boesenbergia pandurata ROXB. SCHLECHT) is one of Indonesia medicinal plants which contains essential oils and flavonoids and it has interesting pharmacological activities, such as antifungal, antibacterial, antioxidant, anti-inflammatory and anti-cancer. It also contains pinostrobin which potent as anti-inflammatory and analgesic activities through inhibition of COX-2 enzymes. This research was to obtain pinostrobin derivatives of acylation reactions between pinostrobin and acyl chloride derivatives. The structure modifications of pinostrobin were obtained by Schotten-Baumann method through nucleophilic substitution reactions between pinostrobin and acyl chloride derivatives. Their structure had analyzed using the spectrophotometric analysis (NMR, IR, and GC/MS). The investigation of structure modifications of pinostrobin (1) from this plant has demonstrated the presence of pinostrobin acetate (2) and new pinostrobin propionate (3). The 2 and 3 are derivatives of pinostrobin that can be synthesized using the Schotten-Baumann method to yield 84.3% and 73.9%, respectively. The results of in silico study between pinostrobin and pinostrobin acyl derivatives on the COX-2 receptor with a PDB code: 1PXX showed that pinostrobin RS value was -87.18kcal/mol, while pinostrobin propionate had a RS value of -98.61 kcal/mol. It can be predicted that the pinostrobin acyl derivative has greater analgesic activity than pinostrobin, so it is feasible to be developed and carried out research on its analgesic activity in vivo.


Cite this article:
Andy Suryadi, Siswandono Siswodihardjo, Tri Widiandani, Retno Widyowati. Structure Modifications of Pinostrobin from Temu Kunci (Boesenbergia pandurata ROXB. SCHLECHT) and Their Analgesic Activity Based on in Silico Studies. Research Journal of Pharmacy and Technology. 2021; 14(4):2089-4. doi: 10.52711/0974-360X.2021.00370

Cite(Electronic):
Andy Suryadi, Siswandono Siswodihardjo, Tri Widiandani, Retno Widyowati. Structure Modifications of Pinostrobin from Temu Kunci (Boesenbergia pandurata ROXB. SCHLECHT) and Their Analgesic Activity Based on in Silico Studies. Research Journal of Pharmacy and Technology. 2021; 14(4):2089-4. doi: 10.52711/0974-360X.2021.00370   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-46


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