Author(s): R. Nagaraju, U. Rajeswari, G. Ravi, P. Subhash Chandra Bose, Damineni Saritha

Email(s): penjurisubhash@gmail.com

DOI: 10.52711/0974-360X.2021.00366   

Address: R. Nagaraju1, U. Rajeswari1, G. Ravi2, P. Subhash Chandra Bose2*, Damineni Saritha3
1Department of Pharmaceutics, Sri Padmavati Mahila Visvavidyalayam, Tirupati - 517502, Andhra Pradesh, India.
2Department of Pharmaceutics, MNR College of Pharmacy, Sangareddy - 502294, Telangana State, India.
3Department of Pharmaceutics, Sultan-ul-Uloom College of Pharmacy, Hyderabad - 500034, TS, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
Microemulsions, by virtue of their lipophilic nature and low globule size, are widely explored as a delivery system to enhance uptake across mucosa. The main aim of the present investigation is to develop and in vitro characterization of intra nasal microemulsion of sumatriptan succinate for brain targeting for treating acute attack of migraine. The liquid microemulsion was prepared by dissolving drug (sumatriptan succinate) and mucoadhesive polymer sodium alginate in double distilled water. The prepared microemulsion was evaluated for particle size measurement, zeta potential measurement, viscosity measurement, centrifugation, drug content, optical clarity and in vitro drug release studies. The prepared formulations were showed particle size in the range of 106.2±2.03 to 282.8±2.51. The zeta potential value of the formulation ME2 showed -32.0mv indicating negative surface charge. The drug content showed in the range of 89.3±0.242 to 94.3±0.128. the optimized formulation showed in vitro drug release 74.2±0.95% at 12 h. and 86.23±0.41% at 24 hrs. From the results it was concluded that the prepared optimized microemulsion formulation as drug delivery system to improve bioavailability of the drugs like sumatriptan succinate.


Cite this article:
R. Nagaraju, U. Rajeswari, G. Ravi, P. Subhash Chandra Bose, Damineni Saritha. Development and in vitro Characterization of Intranasal Microemulsions of Sumatriptan Succinate for brain Targeting. Research Journal of Pharmacy and Technology. 2021; 14(4):2062-8. doi: 10.52711/0974-360X.2021.00366

Cite(Electronic):
R. Nagaraju, U. Rajeswari, G. Ravi, P. Subhash Chandra Bose, Damineni Saritha. Development and in vitro Characterization of Intranasal Microemulsions of Sumatriptan Succinate for brain Targeting. Research Journal of Pharmacy and Technology. 2021; 14(4):2062-8. doi: 10.52711/0974-360X.2021.00366   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-42


REFERENCES:
1. Pathak R, Dash RP, Misra M, Nivsarkar M. Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route. Acta Pharm. Sinica B. 2014; 4(2): 151-160.
2. Savale SK. A Review SNEDDS. Int. J Res. Pharm. Nano Sci.. 2015; 4(6): 385-397.
3. Savale SK. Design and Development of Gefitinib Microemulsion by applying CCRD-RSM model. Asian Journal of Biomaterial Research. 2017; 3(3): 11-21.
4. Patel N, Baldaniya M, Raval M, Sheth N. Formulation and Development of In Situ Nasal Gelling Systems for Quetiapine Fumarate-Loaded Mucoadhesive Microemulsion. J Pharm Innov. 2015; 10(4): 357-373.
5. Jaiswal PL, Darekar AB, Saudagar RB. A recent review on nasal microemulsion for treatment of cns disorder. Int J Curr Pharm Res. 2017; 9(4): 5-13.
6. Savale S, Chalikwar S. Self Micro Emulsifying Drug Delivery System (SMEDDS): A Review. Asian Journal of Biomaterial Research2017; 3(2): 12-17.
7. Savale SK. Sulforhodamine B (SRB) Assay of Curcumin Loaded Nanoemulsion by Using Glioblastoma Cell Line. Asian Journal of Biomaterial Research 2017; 3(3): 26- 30.
8. Mandal S, Mandal SD, Chuttani K, Subudhi BB. Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route. Braz. J. Pharm. Sci. 2015; 51(3): 721-731.
9. Savale SK. UV Spectrophotometric Method Development and Validation for Quantitative Estimation of Curcumin. Asian Journal of Biomaterial Research. 2017; 3(4): 14-18.
10. Mamatha T, Jamal S, Anitha N. Formulation Development and Characterization of Oxcarbazepine Microemulsion for Intranasal Delivery. Acta Pharm. Sci. 2017; 55(2): 79-94.
11. Savale SK. Formulation and Evaluation of Intranasal Microemulsion containing Rutin, Asian Journal of Biomaterial Research. 2017; 3(6): 25-27.
12. Amza B, Rihab O, Samar M, El-shamy AA. Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats. Carbohydr. Polym. 2014; 99: 297-305.
13. Surjyanarayan M, Snigdha DM, Krishna C, Bharat BS. Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route. Brazilian Journal of Pharmaceutical Sciences. 2015; 51(3): 721-731.
14. Brijesh MS, Manju M, Chamanlal JS, Harish P. Nose to brain microemulsion-based drug delivery system of rivastigmine: formulation and ex-vivo characterization. Drug Deliv. 2015; 22(7): 918–930.
15. Mrunali RP, Mitali HP, Rashmin BP. Preparation and in vitro/ex vivo evaluation of nanoemulsion for transnasal delivery of paliperidone. Applied Nanoscience. 2016; 6: 1095-1104.
16. Vaida J, Kristina R, Vitalis B. Design and Formulation of Optimized Microemulsions for Dermal Delivery of Resveratrol. Evidence-Based Complementary and Alternative Medicine. 2015; 1-10.
17. Singh G, Pai RS. Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics and in situ single pass intestinal perfusion (SPIP) studies. Drug Delivery.2015;  22(4): 522–530.
18. Majdi MB, Agha ZM. A Novel Quantitative Spectrophotometric Method for the Analysis of Vigabatrin in Pure Form and in Pharmaceutical Dosage Formula on. Current Pharmaceutical Analysis. 2016; 12: 365-370.
19. Kailash NT, Vikram VN, Madhurma RK. Preparation and evaluation of transnasal microemulsion of Vigabatrin. International Journal of Clinical and Biomedical Research. 2017; 3(4): 54-59.

Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Khan MU, Ghafoor A, Ishaq MT, Hasan B, Salman A, Tengku MA, Zubaidi AL, Nodrin S, Atif AB, Ilyas MN

DOI: 10.5958/0974-360X.2018.00794.1         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Poonam Karekar, Nitin Salunkhe, Adhikrao Yadav, Dnyaneshwar Bangar, Dhanashri Yadav

DOI: Not Available         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Malarkodi Velraj, P. Jasmine Shiney, Biplab Paul, Rashmi. S, Nivethitha

DOI: 10.5958/0974-360X.2017.00006.3         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags