Author(s): G. Haritha, Vijey Aanandhi M, P. Shanmugasundaram

Email(s): director.sps@velsuniv.ac.in

DOI: 10.52711/0974-360X.2021.00365   

Address: G. Haritha1, Vijey Aanandhi M2, P. Shanmugasundaram3*
1Research Scholar, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.
2Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.
3Director, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
Present investigation is based upon a new method development and validation for the simultaneous estimation of drugs comes under the classification of anti-hypertensive and anti-diabetic. For the proposed method metformin, ivabradine, metoprolol and ertugliflozin drugs were selected. The chromatographic separation was achieved by using mobile phase 0.01N potassium dihydrogen ortho phosphate buffer and acetonitrile (50:50) ratio and stationary phase of kromasil C18(250×4.6mm, 5µm) column. The retention times for metformin, ivabradine, metoprolol and ertugliflozin were found to be 2.560min, 3.116 min, 3.473 min and 5.196 min respectively. The developed method shows that all the drugs were clearly separated among each other with the system suitability. The developed method was further validated as per ICH guidelines Q2R1. It was found the method was accurate, presice with good linearity. Hence this method can be used for the routine analysis of these drugs in biological sample.


Cite this article:
G. Haritha, Vijey Aanandhi M, P. Shanmugasundaram. Novel Method Development for Metformin, Ivabradine, Metoprolol and Ertugliflozin and its Validation in API and Pharmaceutical Dosage Form by RPHPLC Method. Research Journal of Pharmacy and Technology. 2021; 14(4):2055-1. doi: 10.52711/0974-360X.2021.00365

Cite(Electronic):
G. Haritha, Vijey Aanandhi M, P. Shanmugasundaram. Novel Method Development for Metformin, Ivabradine, Metoprolol and Ertugliflozin and its Validation in API and Pharmaceutical Dosage Form by RPHPLC Method. Research Journal of Pharmacy and Technology. 2021; 14(4):2055-1. doi: 10.52711/0974-360X.2021.00365   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-41


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DOI: 10.5958/0974-360X 

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