Laith S Abdulhaleem, Omar F Abdul-Rasheed, Salwa J Abdullah Al-Awadi, Thuraya H Abdullah
Laith S Abdulhaleem1*, Omar F Abdul-Rasheed2, Salwa J Abdullah Al-Awadi3, Thuraya H Abdullah4
1PhD Student, Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
2Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
3Department of Biomedical Technologies, College of Applied Biotechnology, Al-Nahrain University, Baghdad-Iraq.
4Al Imamain Teaching Hospital, Baghdad-Iraq.
Volume - 14,
Issue - 4,
Year - 2021
Objectives: to assess the possible association between Angiopoietin-2 (ANGT-2) and the risk of recurrent implantation failure and to determine the possible role of it in the successfulness of in vitro fertilization process. Methods: A case control study was done on 80 female patients with Recurrent Implantation Failure (RIF) and 23 female patients with successful in-vitro fertilization (IVF) who were recruited from the Department of Obstetrics and Gynecology at Al Imamain Al-Kadhimain Medical City, Baghdad, Iraq between January and September 2019. The levels of ANGT-2 were measured in the serum of women with RIF and successful IVF and compared with those with a positive IVF and control group that comprise 74 age, BMI and sex-matched apparently healthy females. Results: The data revealed that there was a significant (p=0.007) decrease in ANGPT2 levels (2914.66±834.08) in women with recurrent implantation failure (RIF) in a comparison with controls (3235.83 ±444.16) whereas non-significant (p>0.05) differences were obtained between women with a successful in vitro fertilization (+ve IVF) and controls and also with RIF group. Conclusions: the possible association between ANGT-2 and the risk of RIF and the possibility of using it as a marker for a prognosis in women subjected to IVF process
Cite this article:
Laith S Abdulhaleem, Omar F Abdul-Rasheed, Salwa J Abdullah Al-Awadi, Thuraya H Abdullah. The association between Angiopoietin-2 and the risk of recurrent implantation failure. Research Journal of Pharmacy and Technology. 2021; 14(4):2031-4. doi: 10.52711/0974-360X.2021.00360
Laith S Abdulhaleem, Omar F Abdul-Rasheed, Salwa J Abdullah Al-Awadi, Thuraya H Abdullah. The association between Angiopoietin-2 and the risk of recurrent implantation failure. Research Journal of Pharmacy and Technology. 2021; 14(4):2031-4. doi: 10.52711/0974-360X.2021.00360 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-36
1. Ali HAE, Ebraheem OM, and Mohamed, S N. Factors affecting pregnancy rates of in vitro fertilization. Journal of American Science 2013; 9(3): 484-495.
2. Kumar N, Singh AK. Trends of male factor infertility, an important cause of infertility: A review of literature. J Hum Reprod Sci 2015; 8: 191-6
3. Bashiri A, Halper KI, Orvieto R. Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions. Reprod Biol Endocrinol. 2018;16(1):121. Published 2018 Dec 5. doi:10.1186/s12958-018-0414-2
4. Drenkhahn M, Gescher DM, Wolber EM, Meyhoefer-Malik A, Malik E. Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane. Fertil. Steril. 2004; 81: 869-875.
5. Shimizu T, Berisha B, Schams D, Miyamoto A. Expression of Angiopoietin (ANPT)-1, ANPT-2 and their Receptors in Dominant Follicles during Periovulatory Period in GnRH‐Treated Cow. Reprod. Domest. Anim. 2007; 42(2): 221-224.
6. Hayashi KG, Berisha B, Matsui M, Schams D, Miyamoto A. Expression of mRNA for the angiopoietin-tie system in granulosa cells during follicular development in cows. J Reprod Dev. 2004; 50: 477-80.
7. Saju SS, Plakkot B, Vazhoor B. A review article on angiopoietins: A crucial ovarian local growth factor. The Pharma Innovation Journal 2018; 7(11): 546-550
8. Ajabi N, Mashayekhi F, Osalou MA. Angiopoietin-2 1087G > A rs3020221 gene polymorphism is associated with in vitro fertilization and embryo transfer outcome. Middle East Fertility Society Journal, 2017;22: 336–339
9. Sallinen H, Heikura T, Koponen J, Kosma VM, Heinonen S, Ylä-Herttuala S, Anttila M. Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer. BMC Cancer 2014;14: 696.
10. Rizov M, Andreeva P, Dimova I. Molecular regulation and role of angiogenesis in reproduction. Taiwan J Obstet Gynecol. 2017;56(2): 127-132.
11. Tal R, Seifer DB, Arici A. The emerging role of angiogenic factor dysregulation in the pathogenesis of polycystic ovarian syndrome. Seminars in Reproductive Medicine. 2015;33(3): 195-207.
12. Daponte A, Deligeoroglou E, Pournaras S, Tsezou A, Garas A, Anastasiadou F, Hadjichristodoulou C, Messinis IE. Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion: a case-control study. Clin Chim Acta. 2013 Jan 16;415: 145-51.
13. Mofarrahi M, Hussain SNA. Expression and Functional Roles of Angiopoietin-2 in Skeletal Muscles. PLoS ONE 2011; 6(7): e22882.