Author(s): Neelamma G, Shaik Harun Rasheed, Anjaneyulu Vinukonda, Aruna M

Email(s): nanisony2012@gmail.com

DOI: 10.52711/0974-360X.2021.00356   

Address: Neelamma G1*, Shaik Harun Rasheed2, Anjaneyulu Vinukonda3, Aruna M2
1Department of Pharmacognosy, Srikrupa Institute of Pharmaceutical Sciences, Velikatta, Kondapak, Siddipet, Telangana, India.
2Department of Pharmaceutics, Srikrupa Institute of Pharmaceutical Sciences, Velikatta, Kondapak, Siddipet, Telangana, India.
3Team Lead, MS & T, Technical Operations, Alembic Pharmaceuticals, Vadodara, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
Clitoria ternatea, Cucurbita maxima, Artemisia vulgaris were the Indian native plants used in the treatment of different diseases. The methanolic extract of Clitoria ternatea, petroleum ether extract of Cucurbita maxima and methanolic extract of Artemisia vulgaris were investigated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. These extracts were assessed using N2a cell line (Neuroblastoma). Cisplatin was used as a positive control based on IC50 values. Artemisia vulgaris methanol extract have highest cytotoxicity (80.81ug/mL) and Cucurbita maxima seed extract have lowest cytotoxicity (57.655ug/mL). The comparison of IC50 of the extracts had shown the following toxicity: Cucurbita maxima petroleum ether extract


Cite this article:
Neelamma G, Shaik Harun Rasheed, Anjaneyulu Vinukonda, Aruna M. In-vitro Screening for Cytotoxic Activity of Herbal Plant Extracts on N2a Cell Lines. Research Journal of Pharmacy and Technology. 2021; 14(4):2009-2. doi: 10.52711/0974-360X.2021.00356

Cite(Electronic):
Neelamma G, Shaik Harun Rasheed, Anjaneyulu Vinukonda, Aruna M. In-vitro Screening for Cytotoxic Activity of Herbal Plant Extracts on N2a Cell Lines. Research Journal of Pharmacy and Technology. 2021; 14(4):2009-2. doi: 10.52711/0974-360X.2021.00356   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-32


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