Comparison of Bone regeneration in hADMSC Versus hUCBMSC with hBMMSC as a Reference: A Literature Review of Potential Bone Regeneration

Sudarmono; Sunardhi Widyaputra; Suhardjo Sitam; Inne Suherna; Arni D. Fitri; Arif Rachman

doi:10.52711/0974-360X.2021.00353

Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)

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Comparison of Bone regeneration in hADMSC Versus hUCBMSC with hBMMSC as a Reference: A Literature Review of Potential Bone Regeneration

Author(s): Sudarmono, Sunardhi Widyaputra, Suhardjo Sitam, Inne Suherna, Arni D. Fitri, Arif Rachman

Email(s): arifrachman8888@gmail.com

DOI: 10.52711/0974-360X.2021.00353

Address: Sudarmono1, Sunardhi Widyaputra2, Suhardjo Sitam3, Inne Suherna4, Arni D. Fitri5, Arif Rachman6*
1Doctoral Degree Study Program in Military Dentistry Science at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
2Department of Oral Biology at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
3Department of Radiology at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
4Department of Pedodontist at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia.
5Veterinary Teaching Hospital, Bogor Agricultural Institute, Bogor, Indonesia.
6Department of Research and Development, Indonesian Naval Dentistry Institute Ladokgi REM, Indonesian Navy Headquarters.
*Corresponding Author

Published In: Volume - 14, Issue - 4, Year - 2021

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ABSTRACT:
Mesenchymal stem cells (MSCs) are an important class of stem cells that can differentiate into osteoblasts, chondrocytes, and adipocytes. MSCs must express CD105, CD73, and CD90 and differentiate into osteoblasts, adipocytes, and chondroblasts. The beneficial effects of MSCs on bone remodeling are mainly provided by a paracrine effect. In bone regeneration, implanted hADMSCs secrete various osteoblast-activating factors, receptor activator of nuclear factor kappa-B ligand (RANKL), BMP-2, BMP-4, hepatocyte growth factor (HGF) and bone-related extracellular matrix proteins. The MSCs possess multipotent capabilities, paracrine, autocrine, and migration capacity to the tissue, directly initiating healing and regeneration with a specified standard. hADMSCs has demonstrated bone regenerative capabilities. DLX5 and RUNX2 as potential bone regeneration references by looking at the osteogenic cells of each source cell. The ability of hADMSC bone regeneration is higher than hUCBMSC due to the capacity of hADMSC osteogenesis which leads to bone and cartilage formation.

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Cite this article:
Sudarmono, Sunardhi Widyaputra, Suhardjo Sitam, Inne Suherna, Arni D. Fitri, Arif Rachman. Comparison of Bone regeneration in hADMSC Versus hUCBMSC with hBMMSC as a Reference: A Literature Review of Potential Bone Regeneration. Research Journal of Pharmacy and Technology. 2021; 14(4):1993-8. doi: 10.52711/0974-360X.2021.00353

Cite(Electronic):
Sudarmono, Sunardhi Widyaputra, Suhardjo Sitam, Inne Suherna, Arni D. Fitri, Arif Rachman. Comparison of Bone regeneration in hADMSC Versus hUCBMSC with hBMMSC as a Reference: A Literature Review of Potential Bone Regeneration. Research Journal of Pharmacy and Technology. 2021; 14(4):1993-8. doi: 10.52711/0974-360X.2021.00353 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-29

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