Polyherbal Formulation Development and Assessment of its Potential against Urolithiasis (Mutrakricchra) by In-Vitro Technique

Swati Sharma; Dileep Singh Baghel; Amit Mittal; Saurabh Singh; Bimlesh Kumar; Pranav Kumar Prabhakar; Anand Kumar Chaudhary

doi:10.52711/0974-360X.2021.00351

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

Submit Article

Polyherbal Formulation Development and Assessment of its Potential against Urolithiasis (Mutrakricchra) by In-Vitro Technique

Author(s): Swati Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Bimlesh Kumar, Pranav Kumar Prabhakar, Anand Kumar Chaudhary

Email(s): dileep.15210@lpu.co.in

DOI: 10.52711/0974-360X.2021.00351

Address: Swati Sharma1, Dileep Singh Baghel1*, Amit Mittal1, Saurabh Singh1, Bimlesh Kumar1, Pranav Kumar Prabhakar2, Anand Kumar Chaudhary3
1School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India.
2Department of Transdisciplinary Research, Lovely Professional University, Punjab, India.
3Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
*Corresponding Author

Published In: Volume - 14, Issue - 4, Year - 2021

View HTML

View PDF

ABSTRACT:
Background: Urolithiasis (Mutrakricchra) is an age-old disorder which has multi-factorial etiological as well as associated with re-occurrence. It is standout among the most troubling disorders related to urinary tract. Acharya Sushruta, a pioneer in the art of surgery, described the root causes and management of urolithiasis (Mutrakricchra). In present day restorative practice, a lot of the management/treatment choices are available which begins from the utilization of uresis-elevating specialist to dietary or nourishing enhancement consumption. Methodologies created by amalgamating the Ayurvedic principle/concept with current medicinal practice are a promising methodology and even effectively used for the management of urolithiasis (Mutrakricchra). Objective: To prepare a poly herbal formulation and evaluate its potential against Urolithiasis (Mutrakrichra) by In-Vitro technique. Materials and Methods: Trikantakadi kvatha was prepared as per the methodology described in Ayurveda Sar Samgraha. Prepared Trikantakadi kvatha was converted in ghan by evaporating the watery portion and Trikantakadi kvatha ghan vati (TKGV) were prepared by adding excipients in prepared ghan. Various parameters performed for physicochemical and phytochemical characterization of raw material (crude herbs) and prepared tablet dosage form. Results: Physicochemical and phytochemical investigations are not shown any remarkable variations with prepared tablet dosage forms when compared with Trikantakadi kvatha churn. Prepared tablet (TKGV) shows crystal inhibition with passage of time the percentage of crystal inhibition also varied accordingly in the drug concentration (1000 µg/ml) showed the maximum 76.25% crystal inhibition. Conclusion: The prepared dosages forms were not exhibited any remarkable variation during physicochemical, phytochemical and thin-layer chromatography studies. However, the Trikantakadi kvatha ghan vati (TKGV) developed dosage forms are more stable than kvatha (Decoction) and produces promising result against Urolithiasis (Mutrakrichra).

Keywords:

Cite this article:
Swati Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Bimlesh Kumar, Pranav Kumar Prabhakar, Anand Kumar Chaudhary. Polyherbal Formulation Development and Assessment of its Potential against Urolithiasis (Mutrakricchra) by In-Vitro Technique. Research Journal of Pharmacy and Technology. 2021; 14(4):1982-8. doi: 10.52711/0974-360X.2021.00351

Cite(Electronic):
Swati Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Bimlesh Kumar, Pranav Kumar Prabhakar, Anand Kumar Chaudhary. Polyherbal Formulation Development and Assessment of its Potential against Urolithiasis (Mutrakricchra) by In-Vitro Technique. Research Journal of Pharmacy and Technology. 2021; 14(4):1982-8. doi: 10.52711/0974-360X.2021.00351 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-27

REFERENCE:

1. Sudarsanam S. and Mooniyandi M.: Potency of Kara Sooda Sathu Parpam, A Herbo Mineral Siddha Drug in the Management of Kalladaippu Noi (Urolithiasis): A Drug Review, Int. J. Res. Ayur. Pharm., 2014, 5(3) 372-379.

2. Sushrutha. Sushruthasamhitha, Uttarathantra, chapter 59, Sloka 2, Krishnada Academy, Varanasi, India, 1980

3. Govindadasa. Bhaishajyaratnavali, Mootrakrichraprakarana, Sloka 2, 7th ed., Kaviraj Ambikadatta Shastri, Chaukhambha Orientalia, Varanasi, India, 1983

4. Shubhashree M.N., Doddamani S.H., Giri S.K., Triveni D.P., Sulochana Bhat. Ayurvedic Management of Paediatric Urolithiasis (Mutrashmari): A Case Report. International Journal of Research in Ayurveda and Pharmacy 2017; P. 3-5

5. Baghel D. S., Chopra S., Bhatia A., Tamilvanan S. Amalgamation of Ayurvedic Concept with Modern Medical Practice to Manage Kidney Stone Disease (Urolithiasis): An Abbreviated Review. Indian Drugs 55 (11) November 2018. Pg. 7-18

6. Narayana swami V and Ali VS. Pashanabheda. J. Res. Indian. Med. 1967; 1: 24.

7. Bahl and Seshadri Advances in research in “Indian Medicine”, “Pashanbedi” drugs for urinary calculus, Udupa, K.N. (Eds), 1970: 77-98.

8. Barry H, Antioxidant effects: A basis for drug selection. Drugs, 1991; 42: 569-605.

9. Rahul Deo Yadav, Shashi Alok, S. K. Jain, Amita Verma, A. Mahor, J. P. Bharti and M. Jaiswal. Herbal Plants Used in the Treatment of Urolithiasis: A Review. IJPSR.0975-8232.2(6).1412-20]

10. Diet for Kidney Stone Prevention, National Kidney and Urologic Diseases Information Clearing House, National Institute of Diabetes, Digestive and Kidney Diseases 2003; P.13-64.

11. D.R smith, editor of General Urology, Urinary stones, chapter 15, California: LANGE medical publications, 8th edition; p 200-216

12. Yadav, Rahul Deo, S. K. Jain, Shashi Alok, Alok Mahor, Jay Prakash Bharti, and Manoj Jaiswal. Herbal plants used in the treatment of urolithiasis: a review. International Journal of Pharmaceutical Sciences and Research 2, no. 6, 2011

13. Tripathi R.D., Astanga Samgraha, Su. Sth. 178/103, Chaukhamba Sanskrit Pratisthan, Delhi; 2003.P.178

14. Pandit Sarangadhara, Sarangadhara Samhita, Md. Kh. 2/3, Commentary by Dr. Brahmanand Tripathi, Chaukhamba Surbharti Prakshana, Varanasi; 2010.P.133-134

15. Jha C., Yogtarangini, 76/10, Commentary by Shri. Datt Ram Mathur, Chaukhamba Vidyabhavan, Varanasi; 2003.P.76

16. Shree Vaidya Ram Narayan Sharma: Ayurveda Sar Samghara, Reprint 11th edition, Baidyanatha Ayurved Bhavan 2011;707

17. Sharma PV, Dravyaguna vigyana, Vol-II, Chaukhambha bhartiya academy, Varanasi; 2012.P.349

18. Kokate C K, Pharmacognosy volume-I and II, Forty-seven edition, Nirali prakashan.

19. Gupta A.K., Tandan N., Sharma M: Quality Standard of Indian Medicinal Plants, Vol. I, II, IV, VII, VIII. Indian Council of Medicinal Research. 2003, 2005, 2006, 2008, 2010.

20. Anonymous. The Ayurvedic Pharmacopoeia of India, Part I, Vol 1-Vol 7, Government of India, Ministry of Health and Family Welfare. Department of AYUSH, Delhi.

21. Anonymous. Protocol for testing Ayurveda, Siddha and Unani medicines, Government of India, Ministry of Health and Family Welfare, Department of AYUSH, PLIM, Ghaziabad 2006

22. Gennaro A.R., Remington: The Science & Practice of Pharmacy volume Lippin cott Williams and Wilkins, International Student edition 2001; P.359

23. Banker GS, Anderson NR, Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd ed; Varghese publishing house, 2003; 314-324

24. Tiwari AK, Dwivedi N, Tripathi Manoj Kumar, Tripathi SP, Standardization and Quality Control of Darvyadi pravahi kvatha- An Ayurvedic Formulation, Indian Journal of Traditional Knowledge; 2016,15:(4), 654-658

25. Raymond C. Rowe H. Kibbe. Handbook of pharmaceutical excipients science and practice, Royal pharmaceutical society of Great Britain: London. 4th edition; 2003:554- 559.

26. Krishnakanth B, Leena KB, Kumar K, Quality Control Tests for Tablets, Pharmaceutical Quality Assurance Concepts; 2010.P.6

27. ICH Harmonised Tripatite Guideline, Stability Testing of New Drug Substances and Products Q1A (R2), Current step 4 version; 6 February 2003

28. Carstensen et al, Stability Testing of Pharmaceutical Products, Journal of Applied Pharmaceutics; 2012.P.129-138

29. Ahmed, Salman, Muhammad Mohtasheemul Hasan, and Zafar Alam Mahmood. "In vitro urolithiasis models: An evaluation of prophylactic management against kidney stones. Journal of Pharmacognosy and Phytochemistry 5, no. 3, 2016

30. Burns JR, Finlayson B. A proposal for standard reference artificial urine in in vitro urolithiasis experiments. J Urol 1980; 18:167-9.