Author(s): Swati Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Bimlesh Kumar, Pranav Kumar Prabhakar, Anand Kumar Chaudhary

Email(s): dileep.15210@lpu.co.in

DOI: 10.52711/0974-360X.2021.00351   

Address: Swati Sharma1, Dileep Singh Baghel1*, Amit Mittal1, Saurabh Singh1, Bimlesh Kumar1, Pranav Kumar Prabhakar2, Anand Kumar Chaudhary3
1School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India.
2Department of Transdisciplinary Research, Lovely Professional University, Punjab, India.
3Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021


ABSTRACT:
Background: Urolithiasis (Mutrakricchra) is an age-old disorder which has multi-factorial etiological as well as associated with re-occurrence. It is standout among the most troubling disorders related to urinary tract. Acharya Sushruta, a pioneer in the art of surgery, described the root causes and management of urolithiasis (Mutrakricchra). In present day restorative practice, a lot of the management/treatment choices are available which begins from the utilization of uresis-elevating specialist to dietary or nourishing enhancement consumption. Methodologies created by amalgamating the Ayurvedic principle/concept with current medicinal practice are a promising methodology and even effectively used for the management of urolithiasis (Mutrakricchra). Objective: To prepare a poly herbal formulation and evaluate its potential against Urolithiasis (Mutrakrichra) by In-Vitro technique. Materials and Methods: Trikantakadi kvatha was prepared as per the methodology described in Ayurveda Sar Samgraha. Prepared Trikantakadi kvatha was converted in ghan by evaporating the watery portion and Trikantakadi kvatha ghan vati (TKGV) were prepared by adding excipients in prepared ghan. Various parameters performed for physicochemical and phytochemical characterization of raw material (crude herbs) and prepared tablet dosage form. Results: Physicochemical and phytochemical investigations are not shown any remarkable variations with prepared tablet dosage forms when compared with Trikantakadi kvatha churn. Prepared tablet (TKGV) shows crystal inhibition with passage of time the percentage of crystal inhibition also varied accordingly in the drug concentration (1000 µg/ml) showed the maximum 76.25% crystal inhibition. Conclusion: The prepared dosages forms were not exhibited any remarkable variation during physicochemical, phytochemical and thin-layer chromatography studies. However, the Trikantakadi kvatha ghan vati (TKGV) developed dosage forms are more stable than kvatha (Decoction) and produces promising result against Urolithiasis (Mutrakrichra).


Cite this article:
Swati Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Bimlesh Kumar, Pranav Kumar Prabhakar, Anand Kumar Chaudhary. Polyherbal Formulation Development and Assessment of its Potential against Urolithiasis (Mutrakricchra) by In-Vitro Technique. Research Journal of Pharmacy and Technology. 2021; 14(4):1982-8. doi: 10.52711/0974-360X.2021.00351

Cite(Electronic):
Swati Sharma, Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Bimlesh Kumar, Pranav Kumar Prabhakar, Anand Kumar Chaudhary. Polyherbal Formulation Development and Assessment of its Potential against Urolithiasis (Mutrakricchra) by In-Vitro Technique. Research Journal of Pharmacy and Technology. 2021; 14(4):1982-8. doi: 10.52711/0974-360X.2021.00351   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-27


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