Formulation, Evaluation and Assessment of In Vitro Potential of  Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra)

Dileep Singh Baghel; Amit Mittal; Saurabh Singh; Anand Kumar Chaudhary; Amit Bhatia; Shruti Chopra

doi:10.52711/0974-360X.2021.00344

Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)

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Formulation, Evaluation and Assessment of In Vitro Potential of Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra)

Author(s): Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra

Email(s): amit.13145@lpu.co.in

DOI: 10.52711/0974-360X.2021.00344

Address: Dileep Singh Baghel1, Amit Mittal1*, Saurabh Singh1, Anand Kumar Chaudhary2, Amit Bhatia3, Shruti Chopra4
1School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar - Delhi G.T. Road, Phagwara, Punjab (India) -144411.
2Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
3Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Punjab, India.
4Amity Institute of Pharmacy, Amity University, Uttar Pradesh, India.
*Corresponding Author

Published In: Volume - 14, Issue - 4, Year - 2021

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ABSTRACT:
Background: Tribulus species spread in the warm, temperate regions and prevalent in zone where hot summers and dry soil present. Tribulus species comprises of more than 25 species. Tribulus terrestris L. (Zygophyllaceae) consists of ripe, dried, whole fruit and an annual herb, rarely perennial that grows worldwide, particularly in the temperate regions. It is used as traditional medicines in India, China, South Africa, Bulgaria and many other countries. It is used for strengthening (balya), nutritive (brimhan), rejuvenator (rasayan), diuretic (mutral), anti-inflammatory (shothahara), renal calculi (ashmari) and urolithiasis (Mutrakrichra). Objective: To prepare Gokshur tablet and evaluate its potential against Urolithiasis (Mutrakrichra) by in vitro technique. Materials and Methods: Gokshur kvatha churna was prepared as per the methodology mentioned in Sharandhar samhita and ghan was prepared by evaporating the watery portion from prepared kvatha. Prepared ghan was compressed into tablet, and quality of tablets were evaluated. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In vitro studies showed 58.24% of crystal inhibition at 650µg/ml. Conclusion: The prepared tablets of Gokshur ghan did not have remarkable variation during physicochemical and stability studies. The prepared tablets were able to show remarkable in vitro activity against Urolithiasis (Mutrakrichra).

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Cite this article:
Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra. Formulation, Evaluation and Assessment of In Vitro Potential of Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology. 2021; 14(4):1945-2. doi: 10.52711/0974-360X.2021.00344

Cite(Electronic):
Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra. Formulation, Evaluation and Assessment of In Vitro Potential of Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology. 2021; 14(4):1945-2. doi: 10.52711/0974-360X.2021.00344 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-20

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