Author(s): Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra


DOI: 10.52711/0974-360X.2021.00344   

Address: Dileep Singh Baghel1, Amit Mittal1*, Saurabh Singh1, Anand Kumar Chaudhary2, Amit Bhatia3, Shruti Chopra4
1School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar - Delhi G.T. Road, Phagwara, Punjab (India) -144411.
2Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.
3Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Punjab, India.
4Amity Institute of Pharmacy, Amity University, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 4,     Year - 2021

Background: Tribulus species spread in the warm, temperate regions and prevalent in zone where hot summers and dry soil present. Tribulus species comprises of more than 25 species. Tribulus terrestris L. (Zygophyllaceae) consists of ripe, dried, whole fruit and an annual herb, rarely perennial that grows worldwide, particularly in the temperate regions. It is used as traditional medicines in India, China, South Africa, Bulgaria and many other countries. It is used for strengthening (balya), nutritive (brimhan), rejuvenator (rasayan), diuretic (mutral), anti-inflammatory (shothahara), renal calculi (ashmari) and urolithiasis (Mutrakrichra). Objective: To prepare Gokshur tablet and evaluate its potential against Urolithiasis (Mutrakrichra) by in vitro technique. Materials and Methods: Gokshur kvatha churna was prepared as per the methodology mentioned in Sharandhar samhita and ghan was prepared by evaporating the watery portion from prepared kvatha. Prepared ghan was compressed into tablet, and quality of tablets were evaluated. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In vitro studies showed 58.24% of crystal inhibition at 650µg/ml. Conclusion: The prepared tablets of Gokshur ghan did not have remarkable variation during physicochemical and stability studies. The prepared tablets were able to show remarkable in vitro activity against Urolithiasis (Mutrakrichra).

Cite this article:
Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra. Formulation, Evaluation and Assessment of In Vitro Potential of Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology. 2021; 14(4):1945-2. doi: 10.52711/0974-360X.2021.00344

Dileep Singh Baghel, Amit Mittal, Saurabh Singh, Anand Kumar Chaudhary, Amit Bhatia, Shruti Chopra. Formulation, Evaluation and Assessment of In Vitro Potential of Gokshur Ghan Tablet against Urolithiasis (Mutrakrichra). Research Journal of Pharmacy and Technology. 2021; 14(4):1945-2. doi: 10.52711/0974-360X.2021.00344   Available on:

1. Traditional Medicine: Definitions. World Health Organization. 2008-12-01. Retrieved 2014-04-20
2. dated 10/07/2019
3. Ferraro, Pietro Manuel, Eric N. Taylor, Brian H. Eisner, Giovanni Gambaro, Eric B. Rimm, Kenneth J. Mukamal, and Gary C. Curhan. History of kidney stones and the risk of coronary heart disease. Jama 310, no. 4 (2013): 408-415
4. Coe, F. L., and A. Evan. Worchester. E Kidney stone disease. J Clin Invest 115, no. 10 (2005): 2598-608
5. Manjula, K., K. Pazhanichami, K. Rajendran, S. Kumaran, and T. Eevera. Herbal remedy for urinary stones. Vegetables and human health. Jodhpur (India): Scientific Publisher (2015): 454-68.
6. Firoz Khan, Md Faheem Haider, Maneesh Kumar Singh, Parul Sharma, Tinku Kumar, Esmaeilli Nezhad Neda. A comprehensive review on kidney stones, its diagnosis and treatment with allopathic and ayurvedic medicines. Urol Nephrol Open Access J. 2019;7(4):69‒74
7. Romero, Victoriano, Haluk Akpinar, and Dean G. Assimos. Kidney stones: a global picture of prevalence, incidence, and associated risk factors. Reviews in urology 12, no. 2-3 (2010): e86.
8. Moe, Orson W. Kidney stones: pathophysiology and medical management. The lancet 367, no. 9507 (2006): 333-344.
9. Stamatelou, Kiriaki K., Mildred E. Francis, Camille A. Jones, Leroy M. Nyberg Jr, and Gary C. Curhan. Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney international 63, no. 5 (2003): 1817-1823. 
10. Pearle, Margaret S., David S. Goldfarb, Dean G. Assimos, Gary Curhan, Cynthia J. Denu-Ciocca, Brian R. Matlaga, Manoj Monga et al.Medical management of kidney stones: AUA guideline. The Journal of urology 192, no. 2 (2014): 316-324.
11. Samhita Charak, and Kashinath Sastri. "Chaukhambha Bharti Academy." Varansi, Reprint 79 (2013): 80-84. 
12. Samhita Sushruta. Adhyaya Sutrasthana. chapter 38, verse 4, 13, 67 and chapter 42, verse 11, edited by Vaidya Jadavaji Trikamji Aacarya and Narayanram Acarya. 1980.
13. Vagbhata, Astanga Sangraha. Sutrasthana 178/103. Saroj Hindi commentary by Indradev Tripathi, Chaukhamba Sanskrit Pratisthan, Varanasi 5 (2005): 27.
14. Chunekar, Krsihna Chand, and G. S. Pandey. Bhavprakash nighantu. Hindi commentary, chukhamba bharti academy varanasi, reprint 314 (2004): 212.
15. Shodhala, Nighantu of Shodhala by Prof. P.V.Sharma publisher Chaukhambha Vidyabhawan,Varanasi,Reprint-1972
16. Vaishy, S. B; Shaligram Nighantu; Khemraj Srikrishnadas Venkteswar Steam Press; Bombay, 1981; 187
17. Kamat, S. D., and S. D. Kamat. Dhanvantari nighantu. Delhi: Chaukhambha Sanskrit Pratisthan (2002): 1.
18. Pandey, G. Madanpal Nighantu. Varanasi: Chowkhambha orientalia (2012)
19. Vaidya, Bapalal G. Nighantu adarsha. Chaukhambha Bharati Academy, Vanarasi, 2nd Ed. I (1998): 211-214
20. Pt. Aryadasa Kumara Singha, Mahaushdha Nighantu with ‘VIDYOTINI’ Hindi commentary and notes by shri Indradeva Tripathi, publisher, Chaukhambha Vidyabhavwan, Varanasi, print-1971
21. Sharma, Acharya Priyavrata. Commentary on Kaidev Nighantu (Gavya Ghrita Guna-271)-Chaukhambha Orientalia. (2009).
22. Narahari, Pandit, and Raj Nighantu. Indradev Tripathi. Krishna Das Academy, Varanasi, p.-29 416 (2003): 443.
23. Vaidyacarya Bopadeva, Hridayadipaka Nighantu with PRAKASA commentary of Vopadeva By Prof.P.V.Sharma, Publisher chaukhambha Amarabharati prakashan,Varanasi,Print-1977
24. Sharma, Priya Vrat. Priya nighantu. Chaukamba Bharti Academy, Varanasi (1983).
25. Sastry, J. L. N. Illustrated Dravyaguna Vijnana. (2ndedn). Chaukhambha Orientalia, Varanasi, India (2005): 513-518.
26. Evans, William Charles. Trease and evans pharmacognosy E-book. Elsevier Health Sciences, 2009.
27. Sharma, P. C., M. B. Yelne, and T. J. Dennis. Database on medicinal plants used in Ayurveda. Vol. 1-3. New Delhi: CCRAS, 2005
28. Kirtikar, K. R., and B. D. Basu. Indian Medicinal Plants: periodical book agency. New Delhi 1 (1998): 686-689.
29. Chatterjee, Asima, and Satyesh Chandra Pakrashi. Treatise on Indian medicinal plants. Publications and Information Directorate, 1991.
30. Anonymous. The Ayurvedic Pharmacopoeia of India, Part I, Vol 1-Vol 9 and Part II, Vol 1-Vol 3, Government of India, Ministry of Health and Family Welfare. Department of AYUSH, Delhi. 
31. Lohar, D. R. Protocol for testing Ayurvedic, Siddha and Unani medicines, Government of India Department of AYUSH. Ghaziabad: Ministry of Health and Family Welfare, Pharmacopoeial Laboratory for Indian Medicines (2007): 21.
32. Gupta, A.K., Neraj Tandon., and Madhu Sharma. Quality Standard of Indian Medicinal Plants (Vol. I, II, III, IV, VII, VIII. Indian Council of Medicinal Research, 2003, 2005, 2006, 2008, 2010.
33. Mannhold, Raimund, Helmut Buschmann, and Jorg Holenz. Innovative Dosage Forms: Design and Development at Early Stage. Vol. 76. John Wiley and Sons, 2019
34. Remington, Joseph Price. Remington: the science and practice of pharmacy. Vol. 1. Lippincott Williams and Wilkins, 2006
35. Lachman, Leon, Herbert A. Lieberman, and Joseph L. Kanig. The theory and practice of industrial pharmacy. Lea and Febiger, 1986
36. Rowe, Raymond C., Paul Sheskey, and Marian Quinn. Handbook of pharmaceutical excipients. Libros digitales-Pharmaceutical Press, 2009.
37. Haritha, B. A Review on Evaluation of Tablets. Journal of Formulation Science and Bioavailability 1, no. 1 (2017): 1-5
38. Ahmed, Salman, Muhammad Mohtasheemul Hasan, and Zafar Alam Mahmood. In vitro urolithiasis models: An evaluation of prophylactic management against kidney stones. Journal of Pharmacognosy and Phytochemistry 5, no. 3 (2016): 28
39. Shah, Muhammad Ajmal, Sikandar Khan Sherwani, Mohammad Sualeh, Sandaleen Kanwal, Haq Nawaz Khan, and Shahana Urooj Kazmi. In vitro anthelmintic and antiurolithic assessment of Berberis lycium root bark. Journal of Pharmacognosy and Phytochemistry 3, no. 2 (2014).

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