Madhuri T. Deshmukh, Shrinivas K. Mohite
Madhuri T. Deshmukh1*, Shrinivas K. Mohite2
1Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon 415404, Maharshtra, India.
2Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon 415404, Maharshtra.
Volume - 14,
Issue - 4,
Year - 2021
Olanzepine a potential antidepressant drug with high affinity of serotonin (5-hydroxytryptamine, 5-HT), dopamine (DA) and noradrenaline (NA) in selected regions of the rat brain. Depression is a debilitating psychiatric condition that remains the second most common cause of disability worldwide. Hence the purpose of present study is to investigate effect of Olanzepine microsphere prepared by using combination of sodium alginate and carbopol polymer on monoamine concentration in rat brain. Our main aim is to study relationship such as serotonin (5HT), dopamine (DA) and nonadrenaline (NA)in the brain of rat It showed that significant reduction occur in monoamine formation in brain of rat. Thus study suggest that prepared Olanzepine microsphere showed decreased the monoamine on rat brain.
Cite this article:
Madhuri T. Deshmukh, Shrinivas K. Mohite. Estimation of Monoamines concentration in rat brain after administration of Olanzepine Microsphere. Research Journal of Pharmacy and Technology. 2021; 14(4):1919-2. doi: 10.52711/0974-360X.2021.00339
Madhuri T. Deshmukh, Shrinivas K. Mohite. Estimation of Monoamines concentration in rat brain after administration of Olanzepine Microsphere. Research Journal of Pharmacy and Technology. 2021; 14(4):1919-2. doi: 10.52711/0974-360X.2021.00339 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-15
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