The objective of present investigation was comparison of porous carriers to increase the dissolution properties of BCS class II drug Ziprasidone. Solvent evaporation method was used for the adsorption of ziprasidone on various porous carriers. Three different porous carriers namely Florite, Neusilin US2, Sylysia 350 were used in the study. Prepared microparticles were characterised for invitro drug release, SEM, XRD and DSC. The optimized formulation containing ziprasidone: florite microparticles had high drug release (94.88% in 45 min) than plain ziprasidone tablets (21.13% in 45 min) which is due to increase in surface area and decrease in crystallinity of drug after adsorption onto porous carrier.
Cite this article:
Ashok Mahajan, Ashish Yadav, Priyal Patel, Shailesh Koradia, Falgun Mehta, Kautuk Shah. Comparative Evaluation of Porous Carriers for Dissolution Improvement of BCS Class II Drug. Research Journal of Pharmacy and Technology. 2021; 14(4):1899-4. doi: 10.52711/0974-360X.2021.00335
Ashok Mahajan, Ashish Yadav, Priyal Patel, Shailesh Koradia, Falgun Mehta, Kautuk Shah. Comparative Evaluation of Porous Carriers for Dissolution Improvement of BCS Class II Drug. Research Journal of Pharmacy and Technology. 2021; 14(4):1899-4. doi: 10.52711/0974-360X.2021.00335 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-11
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