Evaluation of Central Nervous System Depressant Action of  Catharanthus roseus G. Don Leaves in Mice

Manisha Shinde; Sanjay Chaudhari; Ritu Gilhotra

doi:10.5958/0974-360X.2021.00306.1

Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)

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Evaluation of Central Nervous System Depressant Action of Catharanthus roseus G. Don Leaves in Mice

Author(s): Manisha Shinde, Sanjay Chaudhari, Ritu Gilhotra

Email(s): manishaszaware@rediffmail.com

DOI: 10.5958/0974-360X.2021.00306.1

Address: Manisha Shinde*, Sanjay Chaudhari2, Ritu Gilhotra1
1Suresh Gyanvihar University, Jaipur, Rajasthan.
2Trinity College of Pharmacy, Pune.
*Corresponding Author

Published In: Volume - 14, Issue - 3, Year - 2021

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ABSTRACT:
Catharanthus roseus leaves were investigated to assess the CNS depressant activity by using locomotor activity and pentobarbitone induced sleeping time in experimental animal models. Successively extracted petroleum ether, chloroform and ethanol extracts were used in the experiment. Petroleum ether extracts showed significant (p<0.001) and dose dependant CNS depressant activity at the dose of 200 and 400mg/kg oral administration of extracts. Diazepam 4mg/kg, i.p. was used as standard drug. The dose of 100mg/kg didn’t show significant result in the experimental animals. Petroleum ether extract showed presence of steroids, tannins, flavonoids, glycoside, alkaloids and phenolic compounds in qualitative chemical analysis. Petroleum ether extracts is rich in steroid and phenol content including flavonoids, which are reported responsive chemicals for CNS depressant activity in many preclinical studies. The assessed activities of Catharanthus roseus leaves could be due to steroids, glycosides and phenolic compounds.

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Cite this article:
Manisha Shinde, Sanjay Chaudhari, Ritu Gilhotra. Evaluation of Central Nervous System Depressant Action of Catharanthus roseus G. Don Leaves in Mice. Research J. Pharm. and Tech 2021; 14(3):1719-1722. doi: 10.5958/0974-360X.2021.00306.1

REFERENCES:
1.   Hamid, H.A., Ramli, A.N.M., Yusoff, M.M. Indole alkaloids from plants as potential leads for antidepressant drugs: A mini review. Front. Pharmacol. 2017:1-3.
2.   Dhingra D, Sharma A. Review on antidepressant plants. Natural Products Radiance. 2005:144–52.
3.   Cryan JF, Lucki I. Antidepressant like behavioral effects mediated by hydroxy tryptamine receptors. The Journal of Pharmacology experimental Therapeutics. 2000; 295:1120–6.
4.   Zhang J, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li S, Shirayama Y, Hashimoto K. Antidepressant effects of TrkB ligands on depression-like behaviour and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol. 2015:1–12
5.   Ghani A. Medicinal plants of Bangladesh. The Asiatic Society of Bangladesh: Dhaka; 1998.
6.   S. K. Jain, Dictionary of Indian Folk Medicines and Ethnobotany, (Deep Publication, New Delhi, 1991.
7.   K.R. Kirtikar, B.D. Basu. Indian Medicinal Plants. Vol. II, Allahabad, 1546- 1549, 2003.
8.   Sulaiman SF, Wang ST, Ooi KL, Yusuf SR, Muhammad T, Sifzizul T, Anticancer study of Carissa carandas extracts. Project report. Monograph University Sains Malaysia; 2008.
9.   Nammi, S., Boini, M.K., Lodagala, S.D., Behara, R.B.S. The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits. BMC Complement. Altern. Med. 3, 4.2003.
10.   Ghosh, J.S., Patil, P.J., Antimicrobial Activity of Catharanthus roseus – A Detailed Study. Br. J. Pharmacol. Toxicol. 2010, 1, 40–44.
11.   Hassan, K. a., Brenda, A.T., Patrick, V., Patrick, O.E., 2011. In vivo antidiarrheal activity of the ethanolic leaf extract of Catharanthus roseus Linn. (Apocyanaceae) in wistar rats. African J. Pharm. Pharmacol. 5; 1797–1800.
12.   Nayak, B., Pinto Pereira, L.M. Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats. BMC Complement. Altern.Med. 2006; 6 :41.
13.   Rajeswari, D. V, Pharmacological Activities of Catharanthus roseus: a Perspective Review. Int J Pharm Bio Sci. 2013; 4: 431–439.
14.   J.B. Harborne. Phytochemical Methods. Chapman Hall, London pp 60–66, 1998.
15.   C.K. Kokate. Practical Pharmacognosy. Vallabh Prakashan, New Delhi.Pp. 107–113, 1994.
16.   OECD, 2001. OECD Guidelines for the Testing of Chemicals, Section 4, Test No. 425: Acute Oral Toxicity - Up-and-Down Procedure. Guidel. Test. Chem. 26.
17.   M.S. Konawar, K.G. Kamble, M. M. Khandare, K.H. Maharshi, V.B.Awale, Evaluation of the locomotor and diuretic activities of ethanolic extract of leaves of Capparis divaricata Lam (Capparidaceae), International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(4): 265-267,
18.   Rakhshandeh H, Sadeghnia HR, Ghorbani A. Sleep-prolonging effect of Coriandrum sativum hydro-alcoholic extract in mice. Nat. Prod. Rse. 2012; 26: 2095–8.
19.   M. Parvathi and K. Ravishankar, Evaluation of Antidepressant, Motor coordination and locomotor activities of ethanolic root extract of ClitoriaTernatea. Journal of Natural Remedies. 2013, 13(1): 19-24.
20.   Abdul Aziz and Imran Ahmed Khan, Pharmacological evaluation of sedative and hypnotic activities of methanolic extract of Lycopuseuropaeus in mice. The Journal of Phytopharmacology, 2013, 2(4): 8-12.