Author(s): Urvashi Jain, Arti Majumdar, Neelesh Malviya

Email(s): urvashijain0612@gmail.com

DOI: 10.5958/0974-360X.2021.00305.X   

Address: Urvashi Jain*, Arti Majumdar, Neelesh Malviya
Smriti College of Pharmaceutical Education, Indore M.P.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
The target of this analysis is to arrange sublingual tablets of Tenofovir alafenamide with the aim to increase its solubility and therefore rising its oral bioavailability. Materials and Methods: Pure drug, polymer, and different excipients were Characterised by infrared spectrometry and differential scanning measurement. The solid dispersion of Tenofovir alafenamide was ready exploitation beta cyclodextrin and PEG. The solubility of Tenofovir alafenamide was exaggerated by formulating as solid dispersion by kneading techniques. The ready solid dispersion was additional used in the formulation of these tablets. Tablets were developed exploitation superdisintegrants such as crospovidone and sod starch glycolate. In a total range batches of formulations from F1 to F6 were ready by variable superdisintegrants concentration. All these formulations were with success ready and evaluated1. However, results of parameters evaluated conclude that among all ready formulations of these pill have and located to be exaggerated solubility and bioavailability.


Cite this article:
Urvashi Jain, Arti Majumdar, Neelesh Malviya. Formulation and Evaluation of Sublingual Tablet of Tenofovir Alafenamide using Solid Dispersion Method. Research J. Pharm. and Tech 2021; 14(3):1716-1718. doi: 10.5958/0974-360X.2021.00305.X


REFERENCES:
1.    Liberman H, Lachman L, The Theory and Practice of Industrial Pharmacy. 3rd Ed. Bombay: Verghese Publication House, 1991, 171-193.
2.    Lolisson T. Duchene, cyclodextrins and their pharmaceutical application. Int J Pharm 2007; 329:1-11
3.    Richman MD, Fox D. Shangraw RE'. Preparation and stability of glyceryl trinitrate sublingual tablets prepared by direct compression. J Pharm Sci 1965; 54: 447-51.
4.    Rameshwari S, Anandi J. Formulation and evaluation of nifedipine sublingual tablets. Asian J Pharm Clin Res 2009; 2: 41-8.
5.    Dhere M, Majumdar A and Malviya N: Formulation and evaluation of hydrotropic solid dispersion of eluxadoline. Int J Pharm Sci and Res 2019; 10(12): 5450-54.

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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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