Author(s): Annise Proboningrat, Arif Nur Muhammad Ansori, Amaq Fadholly, Naimah Putri, Muhammad Khaliim Jati Kusala, Agung Budianto Achmad

Email(s): ab.achmad@vokasi.unair.ac.id

DOI: 10.5958/0974-360X.2021.00299.7   

Address: Annise Proboningrat1, Arif Nur Muhammad Ansori1, Amaq Fadholly1, Naimah Putri1, Muhammad Khaliim Jati Kusala1, Agung Budianto Achmad2*
1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia.
2Faculty of Vocational Studies, Universitas Airlangga, Surabaya, 60286, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
Pine bark was previously known as a waste product from the lumber industry, but it is now regarded as a natural ingredient that is rich in proanthocyanidin content with potential medicinal properties. This study was aimed to investigate the cytotoxic effects of P. merkusii bark extract (PMBE) on WiDr, a human colon carcinoma cell line. The cytotoxicity test of PMBE was performed using the MTT assay. PMBE inhibited the viability of WiDr cells with an IC50 of 235.60 µg/mL. Despite the weak cytotoxic effect, the current study represents the first report of the potency of PMBE as an anticancer agent in WiDr cell lines. In addition, further observation to find the optimal dosage and mechanism action of PMBE needs to be undertaken as a strategy in human colon carcinoma therapy.


Cite this article:
Annise Proboningrat, Arif Nur Muhammad Ansori, Amaq Fadholly, Naimah Putri, Muhammad Khaliim Jati Kusala, Agung Budianto Achmad. First Report on the Cytotoxicity of Pinus merkusii Bark Extract in WiDr, A Human Colon Carcinoma Cell Line. Research J. Pharm. and Tech 2021; 14(3):1685-1688. doi: 10.5958/0974-360X.2021.00299.7


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